A Genome-Wide Association Study of Depressive Symptoms

Karin Hek; Ayse Demirkan; Jari Lahti; Antonio Terracciano; Alexander Teumer; Marilyn C. Cornelis; Najaf Amin; Erin Bakshis; Jens Baumert; Jingzhong Ding; Yongmei Liu; Kristin Marciante; Osorio Meirelles; Michael A. Nalls; Yan V. Sun; Nicole Vogelzangs; Lei Yu; Stefania Bandinelli; Emelia J. Benjamin; David A. Bennett; Dorret Boomsma; Alessandra Cannas; Laura H. Coker; Eco de Geus; Philip L. De Jager; Ana V. Diez-Roux; Shaun Purcell; Frank B. Hu; Eric B. Rimm; David J. Hunter; Majken K. Jensen; Gary Curhan; Kenneth Rice; Alan D. Penman; Jerome I. Rotter; Nona Sotoodehnia; Rebecca Emeny; Johan G. Eriksson; Denis A. Evans; Luigi Ferrucci; Myriam Fornage; Vilmundur Gudnason; Albert Hofman; Thomas Illig; Sharon Kardia; Margaret Kelly-Hayes; Karestan Koenen; Peter Kraft; Maris Kuningas; Joseph M. Massaro; David Melzer; Antonella Mulas; Cornelis L. Mulder; Anna Murray; Ben A. Oostra; Aarno Palotie; Brenda Penninx; Astrid Petersmann; Luke C. Pilling; Bruce Psaty; Rajesh Rawal; Eric M. Reiman; Andrea Schulz; Joshua M. Shulman; Andrew B. Singleton; Albert V. Smith; Angelina R. Sutin; André G. Uitterlinden; Henry Völzke; Elisabeth Widen; Kristine Yaffe; Alan B. Zonderman; Francesco Cucca; Tamara Harris; Karl-Heinz Ladwig; David J. Llewellyn; Katri Räikkönen; Toshiko Tanaka; Cornelia M. van Duijn; Hans J. Grabe; Lenore J. Launer; Kathryn L. Lunetta; Thomas H. Mosley; Anne B. Newman; Henning Tiemeier; Joanne Murabito

doi:10.1016/j.biopsych.2012.09.033

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A Genome-Wide Association Study of Depressive Symptoms

Journal article

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A Genome-Wide Association Study of Depressive Symptoms

Karin Hek, Ayse Demirkan, Jari Lahti, Antonio Terracciano, Alexander Teumer, Marilyn C. Cornelis, Najaf Amin, Erin Bakshis, Jens Baumert, Jingzhong Ding, …

Biological psychiatry (1969), Vol.73(7), pp.667-678

01/04/2013

DOI: https://doi.org/10.1016/j.biopsych.2012.09.033

PMID: 23290196

Abstract

Center for Epidemiologic Studies Depression Scale

CHARGE consortium

depression

depressive symptoms

genetics

genome-wide association study

meta-analysis

Depression is a heritable trait that exists on a continuum of varying severity and duration. Yet, the search for genetic variants associated with depression has had few successes. We exploit the entire continuum of depression to find common variants for depressive symptoms. In this genome-wide association study, we combined the results of 17 population-based studies assessing depressive symptoms with the Center for Epidemiological Studies Depression Scale. Replication of the independent top hits (p<1×10−5) was performed in five studies assessing depressive symptoms with other instruments. In addition, we performed a combined meta-analysis of all 22 discovery and replication studies. The discovery sample comprised 34,549 individuals (mean age of 66.5) and no loci reached genome-wide significance (lowest p = 1.05×10−7). Seven independent single nucleotide polymorphisms were considered for replication. In the replication set (n = 16,709), we found suggestive association of one single nucleotide polymorphism with depressive symptoms (rs161645, 5q21, p = 9.19×10−3). This 5q21 region reached genome-wide significance (p = 4.78×10−8) in the overall meta-analysis combining discovery and replication studies (n = 51,258). The results suggest that only a large sample comprising more than 50,000 subjects may be sufficiently powered to detect genes for depressive symptoms.

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Title: A Genome-Wide Association Study of Depressive Symptoms
Creators: Karin Hek - Erasmus MC
Ayse Demirkan - Erasmus University Rotterdam
Jari Lahti - University of Helsinki
Antonio Terracciano - National Institutes of Health
Alexander Teumer - Universitätsmedizin Greifswald
Marilyn C. Cornelis - Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts
Najaf Amin - Erasmus University Rotterdam
Erin Bakshis - University of Michigan–Ann Arbor
Jens Baumert - Helmholtz Zentrum München
Jingzhong Ding - Wake Forest University
Yongmei Liu - Wake Forest University
Kristin Marciante - University of Washington
Osorio Meirelles - National Institute on Aging
Michael A. Nalls - National Institute on Aging
Yan V. Sun - Emory University
Nicole Vogelzangs - Amsterdam UMC Location VUmc
Lei Yu - Rush University Medical Center
Stefania Bandinelli - Azienda Sanitaria di Firenze
Emelia J. Benjamin - National Heart Lung and Blood Institute
David A. Bennett - Rush University Medical Center
Dorret Boomsma - University of Amsterdam
Alessandra Cannas - Institute of Genetic and Biomedical Research
Laura H. Coker - Wake Forest University
Eco de Geus - University of Amsterdam
Philip L. De Jager - Brigham and Women's Hospital
Ana V. Diez-Roux - Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, Michigan
Shaun Purcell - Broad Institute
Frank B. Hu - Harvard University
Eric B. Rimm - Harvard University
David J. Hunter - Harvard University
Majken K. Jensen - Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts
Gary Curhan - Brigham and Women's Hospital
Kenneth Rice - University of Washington
Alan D. Penman - University of Mississippi Medical Center
Jerome I. Rotter - Cedars-Sinai Medical Center
Nona Sotoodehnia - University of Washington
Rebecca Emeny - Helmholtz Zentrum München
Johan G. Eriksson - Folkhälsans Forskningscentrum
Denis A. Evans - Rush University Medical Center
Luigi Ferrucci - National Institutes of Health
Myriam Fornage - Brown Foundation
Vilmundur Gudnason - Icelandic Heart Association
Albert Hofman - Erasmus MC
Thomas Illig - Helmholtz Zentrum München
Sharon Kardia - Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, Michigan
Margaret Kelly-Hayes - National Heart Lung and Blood Institute
Karestan Koenen - Columbia University
Peter Kraft - Harvard University
Maris Kuningas - Erasmus MC
Joseph M. Massaro - Framingham Heart Study
David Melzer - Peninsula College of Medicine and Dentistry
Antonella Mulas - Institute of Genetic and Biomedical Research
Cornelis L. Mulder - Erasmus MC
Anna Murray - Peninsula College of Medicine and Dentistry
Ben A. Oostra - Erasmus MC
Aarno Palotie - Institute for Molecular Medicine Finland
Brenda Penninx - EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, The Netherlands
Astrid Petersmann - Universitätsmedizin Greifswald
Luke C. Pilling - Peninsula College of Medicine and Dentistry
Bruce Psaty - Group Health Cooperative
Rajesh Rawal - Helmholtz Zentrum München
Eric M. Reiman - Translational Genomics Research Institute
Andrea Schulz - Universitätsmedizin Greifswald
Joshua M. Shulman - Baylor College of Medicine
Andrew B. Singleton - National Institute on Aging
Albert V. Smith - Icelandic Heart Association
Angelina R. Sutin - National Institutes of Health
André G. Uitterlinden - Erasmus MC
Henry Völzke - Universitätsmedizin Greifswald
Elisabeth Widen - Institute for Molecular Medicine Finland
Kristine Yaffe - University of California, San Francisco
Alan B. Zonderman - National Institute on Aging
Francesco Cucca - Institute of Genetic and Biomedical Research
Tamara Harris - National Institute on Aging
Karl-Heinz Ladwig - Helmholtz Zentrum München
David J. Llewellyn - University of Exeter
Katri Räikkönen - University of Helsinki
Toshiko Tanaka - National Institute on Aging
Cornelia M. van Duijn - Erasmus MC
Hans J. Grabe - Universitätsmedizin Greifswald
Lenore J. Launer - National Institute on Aging
Kathryn L. Lunetta - Boston University
Thomas H. Mosley - University of Mississippi Medical Center
Anne B. Newman - University of Pittsburgh
Henning Tiemeier - Erasmus MC
Joanne Murabito - National Heart Lung and Blood Institute
Publication Details: Biological psychiatry (1969), Vol.73(7), pp.667-678
Publisher: Elsevier Inc
Number of pages: 12
Date published: 01/04/2013
Identifiers: 99928794202346
Academic Unit: Institute for Sustainability; Surrey Institute for People-Centred AI; School of Biosciences
Language: English
Resource Type: Journal article

A Genome-Wide Association Study of Depressive Symptoms

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