A Topological Cluster of Differentially Regulated Genes in Mice Lacking PER3

Daan R. van der Veen; Emma Laing; Sung-Eun Bae; Jonathan Johnston; Derk-Jan Dijk; Simon Archer

doi:10.3389/fnmol.2020.00015

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A Topological Cluster of Differentially Regulated Genes in Mice Lacking PER3

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A Topological Cluster of Differentially Regulated Genes in Mice Lacking PER3

Daan R. van der Veen, Emma Laing, Sung-Eun Bae, Jonathan Johnston, Derk-Jan Dijk and Simon Archer

Frontiers in Molecular Neuroscience, Vol.13(15)

15/04/2020

DOI: https://doi.org/10.3389/fnmol.2020.00015

Abstract

mouse

circadian

topological associating domain

transcriptome

Metabolism

Polymorphisms in the human circadian clock gene PERIOD3 (PER3) are associated with a wide variety of phenotypes such as diurnal preference, delayed sleep phase disorder, sleep homeostasis, cognitive performance, bipolar disorder, type 2 diabetes, cardiac regulation, cancer, light sensitivity, hormone and cytokine secretion, and addiction. However, the molecular mechanisms underlying these phenotypic associations remain unknown. Per3 knockout mice (Per3

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Title: A Topological Cluster of Differentially Regulated Genes in Mice Lacking PER3
Creators: Daan R. van der Veen
Emma Laing
Sung-Eun Bae
Jonathan Johnston
Derk-Jan Dijk
Simon Archer
Publication Details: Frontiers in Molecular Neuroscience, Vol.13(15)
Publisher: Frontiers Media
First online publication date: 15/04/2020
Grant note: Funder: Biotechnology and Biological Sciences Research Council (BBSRC) | Grant ID: BB/E003672/1 | Grant ID: BB/F022883 | Grant ID: BB/F020309/1
Identifiers: 99511428202346; WOS:000518607300001
Copyright: Copyright © 2020 Van der Veen, Laing, Bae, Johnston, Dijk and Archer. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Academic Unit: School of Biosciences
Resource Type: Journal article
SDG (Scopus 2023): SDG 3

A Topological Cluster of Differentially Regulated Genes in Mice Lacking PER3

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