Abstract
In this paper we introduce a research agenda to guide the development of the next generation of Discrete Event Simulation (DES) systems. Interfaces to digital twins are projected to go beyond physical representations to become blueprints for the actual “objects” and an active dashboard for their control. The role and importance of real-time interactive animations presented in an Extended Reality (XR) format will be explored. The need for using game engines, particularly their physics engines and AI within interactive simulated Extended Reality is expanded on. Importing and scanning real-world environments is assumed to become more efficient when using AR. Exporting to VR and AR is recommended to be a default feature. A technology framework for the next generation simulators is presented along with a proposed set of implementation guidelines. The need for more human centric technology approaches, nascent in Industry 4.0, are now central to the emerging Industry 5.0 paradigm; an agenda that is discussed in this research as part of a human in the loop future, supported by DES. The potential role of Explainable Artificial Intelligence is also explored along with an audit trail approach to provide a justification of complex and automated decision-making systems with relation to DES. A technology framework is proposed, which brings the above together and can serve as a guide for the next generation of holistic simulators for manufacturing.