Rapid access to CF3-containing heterocycles

Adrian P. Dobbs; Robert J. Parker; John Skidmore

doi:10.1016/j.tetlet.2007.11.178

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Rapid access to CF3-containing heterocycles

Journal article

Peer reviewed

Rapid access to CF3-containing heterocycles

Adrian P. Dobbs, Robert J. Parker and John Skidmore

Tetrahedron letters, Vol.49(5), pp.827-831

28/01/2008

DOI: https://doi.org/10.1016/j.tetlet.2007.11.178

Abstract

Chemistry

Chemistry, Organic

Physical Sciences

Science & Technology

The silyl-Prins and aza-silyl-Prins reactions have been employed for the preparation of 6-CF3-substituted dihydropyrans and 6-CF3-substituted tetrahydropyridines. The product heterocycles have been further elaborated to a number of products, including CF3-substituted pipecolates and hydroxylated pyrans and piperidines. (C) 2007 Elsevier Ltd. All rights reserved.

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Title: Rapid access to CF3-containing heterocycles
Creators: Adrian P. Dobbs - University of Exeter
Robert J. Parker - University of Exeter
John Skidmore - GlaxoSmithKline
Publication Details: Tetrahedron letters, Vol.49(5), pp.827-831
Publisher: Elsevier
Number of pages: 5
Publication Date: 28/01/2008
Grant note: EP/E037259/1 / Engineering and Physical Sciences Research Council; UK Research & Innovation (UKRI); Engineering & Physical Sciences Research Council (EPSRC) EP/E037259/1 / EPSRC; UK Research & Innovation (UKRI); Engineering & Physical Sciences Research Council (EPSRC)
Identifiers: 99959867302346; WOS:000253170200020
Academic Unit: School of Chemistry and Chemical Engineering; Department of Chemistry
Language: English
Resource Type: Journal article

Rapid access to CF3-containing heterocycles

Abstract

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