A genome-wide association meta-analysis identifies new childhood obesity loci

Jonathan P. Bradfield; H. Rob Taal; Nicholas J. Timpson; Andre Scherag; Cecile Lecoeur; Nicole M. Warrington; Elina Hypponen; Claus Holst; Beatriz Valcarcel; Elisabeth Thiering; Rany M. Salem; Fredrick R. Schumacher; Diana L. Cousminer; Patrick M. A. Sleiman; Jianhua Zhao; Robert I. Berkowitz; Karani S. Vimaleswaran; Ivonne Jarick; Craig E. Pennell; David M. Evans; Beate St Pourcain; Diane J. Berry; Dennis O. Mook-Kanamori; Albert Hofman; Fernando Rivadeneira; Andre G. Uitterlinden; Cornelia M. van Duijn; Ralf J. P. van der Valk; Johan C. de Jongste; Dirkje S. Postma; Dorret I. Boomsma; W. James Gauderman; Mohamed T. Hassanein; Cecilia M. Lindgren; Reedik Magi; Colin A. G. Boreham; Charlotte E. Neville; Luis A. Moreno; Paul Elliott; Anneli Pouta; Anna-Liisa Hartikainen; Mingyao Li; Olli Raitakari; Terho Lehtimaki; Johan G. Eriksson; Aarno Palotie; Jean Dallongeville; Shikta Das; Panos Deloukas; George McMahon; Susan M. Ring; John P. Kemp; Jessica L. Buxton; Alexandra I. F. Blakemore; Mariona Bustamante; Monica Guxens; Joel N. Hirschhorn; Matthew W. Gillman; Eskil Kreiner-Moller; Hans Bisgaard; Frank D. Gilliland; Joachim Heinrich; Eleanor Wheeler; Ines Barroso; Stephen O'Rahilly; Aline Meirhaeghe; Thorkild I. A. Sorensen; Chris Power; Lyle J. Palmer; Anke Hinney; Elisabeth Widen; I. Sadaf Farooqi; Mark I. McCarthy; Philippe Froguel; David Meyre; Johannes Hebebrand; Marjo-Riitta Jarvelin; Vincent W. V. Jaddoe; George Davey Smith; Hakon Hakonarson; Struan F. A. Grant; Early Growth Genetics EGG Consorti; Inga Prokopenko

doi:10.1038/ng.2247

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A genome-wide association meta-analysis identifies new childhood obesity loci

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A genome-wide association meta-analysis identifies new childhood obesity loci

Jonathan P. Bradfield, H. Rob Taal, Nicholas J. Timpson, Andre Scherag, Cecile Lecoeur, Nicole M. Warrington, Elina Hypponen, Claus Holst, Beatriz Valcarcel, Elisabeth Thiering, …

Nature genetics, Vol.44(5), pp.526-531

01/05/2012

DOI: https://doi.org/10.1038/ng.2247

PMID: 22484627

Abstract

Genetics & Heredity

Life Sciences & Biomedicine

Science & Technology

Multiple genetic variants have been associated with adult obesity and a few with severe obesity in childhood; however, less progress has been made in establishing genetic influences on common early-onset obesity. We performed a North American, Australian and European collaborative meta-analysis of 14 studies consisting of 5,530 cases (>= 95th percentile of body mass index (BMI)) and 8,318 controls (<50th percentile of BMI) of European ancestry. Taking forward the eight newly discovered signals yielding association with P < 5 x 10(-6) in nine independent data sets (2,818 cases and 4,083 controls), we observed two loci that yielded genome-wide significant combined P values near OLFM4 at 13q14 (rs9568856; P = 1.82 x 10(-9); odds ratio (OR) = 1.22) and within HOXB5 at 17q21 (rs9299; P = 3.54 x 10(-9); OR = 1.14). Both loci continued to show association when two extreme childhood obesity cohorts were included (2,214 cases and 2,674 controls). These two loci also yielded directionally consistent associations in a previous metaanalysis of adult BMI1.

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Title: A genome-wide association meta-analysis identifies new childhood obesity loci
Creators: Jonathan P. Bradfield - Children's Hospital of Philadelphia
H. Rob Taal - Erasmus MC
Nicholas J. Timpson - University of Bristol
Andre Scherag - University of Duisburg-Essen
Cecile Lecoeur - Université de Lille
Nicole M. Warrington - Univ Western Australia, Sch Womens & Infants Hlth, Perth, WA 6009, Australia
Elina Hypponen - Biostat
Claus Holst - College Station Medical Center
Beatriz Valcarcel - University of London
Elisabeth Thiering - German Res Ctr Environm Hlth, Helmholtz Zentrum Muenchen, Inst Epidemiol 1, Neuherberg, Germany
Rany M. Salem - Childrens Hosp, Div Genet, Boston, MA 02115 USA
Fredrick R. Schumacher - Supreme Council Of Health
Diana L. Cousminer - University of Helsinki
Patrick M. A. Sleiman - Childrens Hosp Philadelphia, Ctr Appl Genom, Abramson Res Ctr, Philadelphia, PA 19104 USA
Jianhua Zhao - Childrens Hosp Philadelphia, Div Human Genet, Philadelphia, PA 19104 USA
Robert I. Berkowitz - Childrens Hosp Philadelphia, Dept Child & Adolescent Psychiat & Behav Sci, Philadelphia, PA 19104 USA
Karani S. Vimaleswaran - Biostat
Ivonne Jarick - College Station Medical Center
Craig E. Pennell - Univ Western Australia, Sch Womens & Infants Hlth, Perth, WA 6009, Australia
David M. Evans - University of Bristol
Beate St Pourcain - University of Bristol
Diane J. Berry - Biostat
Dennis O. Mook-Kanamori - Erasmus MC
Albert Hofman - Erasmus MC
Fernando Rivadeneira - Erasmus MC
Andre G. Uitterlinden - Erasmus MC
Cornelia M. van Duijn - Erasmus MC
Ralf J. P. van der Valk - Erasmus MC
Johan C. de Jongste - Erasmus MC
Dirkje S. Postma - University of Groningen
Dorret I. Boomsma - University of Amsterdam
W. James Gauderman - Supreme Council Of Health
Mohamed T. Hassanein - Supreme Council Of Health
Cecilia M. Lindgren - University of Oxford
Reedik Magi - University of Oxford
Colin A. G. Boreham - Univ Coll Dublin, Inst Sport & Hlth, Dublin 2, Ireland
Charlotte E. Neville - Queens University
Luis A. Moreno - Univ Zaragoza, Growth Exercise Nutr & Dev GENUD Res Grp, Zaragoza, Spain
Paul Elliott - University of London
Anneli Pouta - Natl Inst Hlth & Welf, Dept Lifecourse & Serv, Oulu, Finland
Anna-Liisa Hartikainen - University of Oulu
Mingyao Li - Biostat
Olli Raitakari - Turku Univ Hosp, Dept Clin Physiol, FIN-20520 Turku, Finland
Terho Lehtimaki - Tampere University
Johan G. Eriksson - Natl Inst Hlth & Welf, Helsinki, Finland
Aarno Palotie - Harvard University
Jean Dallongeville - Université de Lille
Shikta Das - University of London
Panos Deloukas - Wellcome Sanger Institute
George McMahon - University of Bristol
Susan M. Ring - University of Bristol
John P. Kemp - University of Bristol
Jessica L. Buxton - University of London
Alexandra I. F. Blakemore - University of London
Mariona Bustamante - Ctr Res Environm Epidemiol CREAL, Barcelona, Spain
Monica Guxens - Ctr Res Environm Epidemiol CREAL, Barcelona, Spain
Joel N. Hirschhorn - Childrens Hosp, Div Genet, Boston, MA 02115 USA
Matthew W. Gillman - Harvard University
Eskil Kreiner-Moller - University of Copenhagen
Hans Bisgaard - University of Copenhagen
Frank D. Gilliland - Supreme Council Of Health
Joachim Heinrich - German Res Ctr Environm Hlth, Helmholtz Zentrum Muenchen, Inst Epidemiol 1, Neuherberg, Germany
Eleanor Wheeler - Wellcome Sanger Institute
Ines Barroso - Wellcome Sanger Institute
Stephen O'Rahilly - University of Cambridge
Aline Meirhaeghe - Université de Lille
Thorkild I. A. Sorensen - College Station Medical Center
Chris Power - Biostat
Lyle J. Palmer - Ontario Inst Canc Res, Toronto, ON, Canada
Anke Hinney - University of Duisburg-Essen
Elisabeth Widen - University of Helsinki
I. Sadaf Farooqi - University of Cambridge
Mark I. McCarthy - University of Oxford
Philippe Froguel - Université de Lille
David Meyre - Université de Lille
Johannes Hebebrand - University of Duisburg-Essen
Marjo-Riitta Jarvelin - University of London
Vincent W. V. Jaddoe - Erasmus MC
George Davey Smith - University of Bristol
Hakon Hakonarson - Childrens Hosp Philadelphia, Ctr Appl Genom, Abramson Res Ctr, Philadelphia, PA 19104 USA
Struan F. A. Grant - Childrens Hosp Philadelphia, Ctr Appl Genom, Abramson Res Ctr, Philadelphia, PA 19104 USA
Early Growth Genetics EGG Consorti
Inga Prokopenko - School of Biosciences
Publication Details: Nature genetics, Vol.44(5), pp.526-531
Publisher: Springer Nature
Number of pages: 7
Date published: 01/05/2012
Grant note: R01 HD056465-04; R01 HD056465-05; R01 HD056465; R24 HD050924; R01 HD056465-03; R01 HD056465-01A1; R01 HD056465-02 / NICHD NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD) RD831861-01 / ORD VA R01 MH063706; RL1 MH083268; 1RL1MH083268-01; 5R01MH63706:02 / NIMH NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Mental Health (NIMH) R01DK075787 / NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) 090532; 068545/Z/02; 076467; WT088431MA; 086596/Z/08/Z; GR069224; 077016/Z/05/Z; 092731; 098395; 052515/2/97/2; 083948 / Wellcome Trust; European Commission MOP-82893 / CIHR; Canadian Institutes of Health Research (CIHR) PHCS/C4/4/016 / Department of Health; European Commission R01HL087679 / NATIONAL HEART, LUNG, AND BLOOD INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) R826708-01 / PHS HHS; United States Department of Health & Human Services; United States Public Health Service PG/1996183/9569; PG/09/023; PG/09/023/26806 / British Heart Foundation
Identifiers: 99929041902346
Academic Unit: School of Biosciences
Language: English
Resource Type: Journal article

A genome-wide association meta-analysis identifies new childhood obesity loci

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