Common variants at 12q15 and 12q24 are associated with infant head circumference

H. Rob Taal; Beate St Pourcain; Elisabeth Thiering; Shikta Das; Dennis O. Mook-Kanamori; Nicole M. Warrington; Marika Kaakinen; Eskil Kreiner-Moller; Jonathan P. Bradfield; Rachel M. Freathy; Frank Geller; Monica Guxens; Diana L. Cousminer; Marjan Kerkhof; Nicholas J. Timpson; M. Arfan Ikram; Lawrence J. Beilin; Klaus Bonnelykke; Jessica L. Buxton; Pimphen Charoen; Bo Lund Krogsgaard Chawes; Johan Eriksson; David M. Evans; Albert Hofman; John P. Kemp; Cecilia E. Kim; Norman Klopp; Jari Lahti; Stephen J. Lye; George McMahon; Frank D. Mentch; Martina Mueller-Nurasyid; Paul F. O'Reilly; Inga Prokopenko; Fernando Rivadeneira; Eric A. P. Steegers; Jordi Sunyer; Carla Tiesler; Hanieh Yaghootkar; Monique M. B. Breteler; Stephanie Debette; Myriam Fornage; Vilmundur Gudnason; Lenore J. Launer; Aad van der Lugt; Thomas H. Mosley; Sudha Seshadri; Albert V. Smith; Meike W. Vernooij; Alexandra I. F. Blakemore; Rosetta M. Chiavacci; Bjarke Feenstra; Julio Fernandez-Banet; Struan F. A. Grant; Anna-Liisa Hartikainen; Albert J. van der Heijden; Carmen Iniguez; Mark Lathrop; Wendy L. McArdle; Anne Molgaard; John P. Newnham; Lyle J. Palmer; Aarno Palotie; Annneli Pouta; Susan M. Ring; Ulla Sovio; Marie Standl; Andre G. Uitterlinden; H-Erich Wichmann; Nadja Hawwa Vissing; Charles DeCarli; Cornelia M. van Duijn; Mark I. McCarthy; Gerard H. Koppelman; Xavier Estivill; Andrew T. Hattersley; Mads Melbye; Hans Bisgaard; Craig E. Pennell; Elisabeth Widen; Hakon Hakonarson; George Davey Smith; Joachim Heinrich; Marjo-Riitta Jarvelin; Vincent W. V. Jaddoe; Linda S. Adair; Wei Ang; Mustafa Atalay; Toos van Beijsterveldt; Nienke Bergen; Kelly Benke; Diane Berry; Lachlan Coin; Oliver S. P. Davis; Paul Elliott; Claudia Flexeder; Tim Frayling; Romy Gaillard; Maria Groen-Blokhuis; Liang-Kee Goh; Cohorts Heart Aging Res Genetic Ep

doi:10.1038/ng.2238

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Common variants at 12q15 and 12q24 are associated with infant head circumference

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Common variants at 12q15 and 12q24 are associated with infant head circumference

H. Rob Taal, Beate St Pourcain, Elisabeth Thiering, Shikta Das, Dennis O. Mook-Kanamori, Nicole M. Warrington, Marika Kaakinen, Eskil Kreiner-Moller, Jonathan P. Bradfield, Rachel M. Freathy, …

Nature genetics, Vol.44(5), pp.532-538

01/05/2012

DOI: https://doi.org/10.1038/ng.2238

PMID: 22504419

Abstract

Genetics & Heredity

Life Sciences & Biomedicine

Science & Technology

To identify genetic variants associated with head circumference in infancy, we performed a meta-analysis of seven genome-wide association studies (GWAS) (N = 10,768 individuals of European ancestry enrolled in pregnancy and/or birth cohorts) and followed up three lead signals in six replication studies (combined N = 19,089). rs7980687 on chromosome 12q24 (P = 8.1 x 10(-9)) and rs1042725 on chromosome 12q15 (P = 2.8 x 10(-10)) were robustly associated with head circumference in infancy. Although these loci have previously been associated with adult height(1), their effects on infant head circumference were largely independent of height (P = 3.8 x 10(-7) for rs7980687 and P = 1.3 x 10(-7) for rs1042725 after adjustment for infant height). A third signal, rs11655470 on chromosome 17q21, showed suggestive evidence of association with head circumference (P = 3.9 x 10(-6)). SNPs correlated to the 17q21 signal have shown genome-wide association with adult intracranial volume(2), Parkinson's disease and other neurodegenerative diseases(3-5), indicating that a common genetic variant in this region might link early brain growth with neurological disease in later life.

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Title: Common variants at 12q15 and 12q24 are associated with infant head circumference
Creators: H. Rob Taal - Erasmus MC
Beate St Pourcain
Elisabeth Thiering - Helmholtz Zentrum München
Shikta Das - Imperial College London
Dennis O. Mook-Kanamori - Erasmus MC
Nicole M. Warrington - University of Western Australia
Marika Kaakinen - University of Oulu
Eskil Kreiner-Moller - University of Copenhagen
Jonathan P. Bradfield - Children's Hospital of Philadelphia
Rachel M. Freathy - University of Bristol
Frank Geller - Statens Serum Institut
Monica Guxens - Center for Research in Environmental Epidemiology
Diana L. Cousminer - Institute for Molecular Medicine Finland
Marjan Kerkhof - University Medical Center Groningen
Nicholas J. Timpson - University of Bristol
M. Arfan Ikram - Erasmus MC
Lawrence J. Beilin - University of Western Australia
Klaus Bonnelykke - University of Copenhagen
Jessica L. Buxton - Imperial College London
Pimphen Charoen - Imperial College London
Bo Lund Krogsgaard Chawes - University of Copenhagen
Johan Eriksson - Finnish Institute for Health and Welfare
David M. Evans - Medical Research Council
Albert Hofman - Erasmus MC
John P. Kemp - Medical Research Council
Cecilia E. Kim - Children's Hospital of Philadelphia
Norman Klopp - Helmholtz Zentrum München
Jari Lahti - University of Helsinki
Stephen J. Lye - Lunenfeld-Tanenbaum Research Institute
George McMahon - University of Bristol
Frank D. Mentch - Children's Hospital of Philadelphia
Martina Mueller-Nurasyid - Ludwig-Maximilians-Universität München
Paul F. O'Reilly - University of London
Inga Prokopenko - Oxford Centre for Diabetes, Endocrinology and Metabolism
Fernando Rivadeneira - Erasmus MC
Eric A. P. Steegers - Erasmus MC
Jordi Sunyer - Center for Research in Environmental Epidemiology
Carla Tiesler - Helmholtz Zentrum München
Hanieh Yaghootkar - University of Exeter
Monique M. B. Breteler - Erasmus MC
Stephanie Debette - Boston University
Myriam Fornage - The University of Texas Health Science Center at Houston
Vilmundur Gudnason - Iceland Res Inst, Kopavogur, Iceland
Lenore J. Launer - National Institute on Aging
Aad van der Lugt - Erasmus MC
Thomas H. Mosley - University of Mississippi Medical Center
Sudha Seshadri - Boston University
Albert V. Smith - Iceland Res Inst, Kopavogur, Iceland
Meike W. Vernooij - Erasmus MC
Alexandra I. F. Blakemore - Imperial College London
Rosetta M. Chiavacci - Children's Hospital of Philadelphia
Bjarke Feenstra - Statens Serum Institut
Julio Fernandez-Banet - European Bioinformatics Institute
Struan F. A. Grant - Children's Hospital of Philadelphia
Anna-Liisa Hartikainen - University of Oulu
Albert J. van der Heijden - Erasmus MC
Carmen Iniguez - Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública
Mark Lathrop - Evry
Wendy L. McArdle - University of Bristol
Anne Molgaard - University of Copenhagen
John P. Newnham - University of Western Australia
Lyle J. Palmer - Lunenfeld-Tanenbaum Research Institute
Aarno Palotie - Institute for Molecular Medicine Finland
Annneli Pouta - University of Oulu
Susan M. Ring - University of Bristol
Ulla Sovio - Imperial College London
Marie Standl - Helmholtz Zentrum München
Andre G. Uitterlinden - Erasmus MC
H-Erich Wichmann - Helmholtz Zentrum München
Nadja Hawwa Vissing - Gentofte Hospital
Charles DeCarli - University of California, Davis
Cornelia M. van Duijn - Erasmus MC
Mark I. McCarthy - Oxford Centre for Diabetes, Endocrinology and Metabolism
Gerard H. Koppelman - University Medical Center Groningen
Xavier Estivill - Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública
Andrew T. Hattersley - University of Exeter
Mads Melbye - Statens Serum Institut
Hans Bisgaard - University of Copenhagen
Craig E. Pennell - University of Western Australia
Elisabeth Widen - Institute for Molecular Medicine Finland
Hakon Hakonarson - Children's Hospital of Philadelphia
George Davey Smith - University of Bristol
Joachim Heinrich - Helmholtz Zentrum München
Marjo-Riitta Jarvelin - University of Oulu
Vincent W. V. Jaddoe - Erasmus MC
Linda S. Adair - Univ N Carolina, Dept Nutr, Chapel Hill, NC USA
Wei Ang - Univ Western Australia, Sch Womens & Infants Hlth, Perth, WA 6009, Australia
Mustafa Atalay - University of Eastern Finland
Toos van Beijsterveldt - University of Amsterdam
Nienke Bergen - Erasmus MC
Kelly Benke - Univ Western Australia, Sch Womens & Infants Hlth, Perth, WA 6009, Australia
Diane Berry - Biostat
Lachlan Coin - University of London
Oliver S. P. Davis - Massachusetts Rehabilitation Commission
Paul Elliott - University of London
Claudia Flexeder - Helmholtz Zentrum München
Tim Frayling - University of Exeter
Romy Gaillard - Erasmus MC
Maria Groen-Blokhuis - University of Amsterdam
Liang-Kee Goh - Supreme Council Of Health
Cohorts Heart Aging Res Genetic Ep
Publication Details: Nature genetics, Vol.44(5), pp.532-538
Publisher: NATURE PORTFOLIO
Number of pages: 9
Date published: 01/05/2012
Grant note: 21000074 / ZonMW; Netherlands Organization for Health Research and Development German Research Center for Environment and Health British Heart Foundation Institut fur Umweltmedizinische Forschung (IUF) Dusseldorf Netherlands Organisation for Scientific Research (NWO); Netherlands Organization for Scientific Research (NWO) Cotswold Foundation GR069224; 085541/Z/08/Z; WT083431MA; WT088431MA / Wellcome Trust The Children's Hospital of Philadelphia MOP 82893 / Canadian Institutes of Health Research; Canadian Institutes of Health Research (CIHR) Erasmus University Rotterdam
Identifiers: 99929027202346
Academic Unit: School of Biosciences
Language: English
Resource Type: Journal article

Common variants at 12q15 and 12q24 are associated with infant head circumference

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