Common variants associated with plasma triglycerides and risk for coronary artery disease

Ron Do; Cristen J. Willer; Ellen M. Schmidt; Sebanti Sengupta; Chi Gao; Gina M. Peloso; Stefan Gustafsson; Stavroula Kanoni; Andrea Ganna; Jin Chen; Martin L. Buchkovich; Samia Mora; Jacques S. Beckmann; Jennifer L. Bragg-Gresham; Hsing-Yi Chang; Ayse Demirkan; Heleen M. Den Hertog; Louise A. Donnelly; Georg B. Ehret; Tonu Esko; Mary F. Feitosa; Teresa Ferreira; Krista Fischer; Pierre Fontanillas; Ross M. Fraser; Daniel F. Freitag; Deepti Gurdasani; Kauko Heikkila; Elina Hyppoenen; Aaron Isaacs; Anne U. Jackson; Asa Johansson; Toby Johnson; Marika Kaakinen; Johannes Kettunen; Marcus E. Kleber; Xiaohui Li; Jian'an Luan; Leo-Pekka Lyytikainen; Patrik K. E. Magnusson; Massimo Mangino; Evelin Mihailov; May E. Montasser; Martina Mueller-Nurasyid; Ilja M. Nolte; Jeffrey R. O'Connell; Cameron D. Palmer; Markus Perola; Ann-Kristin Petersen; Serena Sanna; Richa Saxena; Susan K. Service; Sonia Shah; Dmitry Shungin; Carlo Sidore; Ci Song; Rona J. Strawbridge; Ida Surakka; Toshiko Tanaka; Tanya M. Teslovich; Gudmar Thorleifsson; Evita G. Van den Herik; Benjamin F. Voight; Kelly A. Volcik; Lindsay L. Waite; Andrew Wong; Ying Wu; Weihua Zhang; Devin Absher; Gershim Asiki; Ines Barroso; Latonya F. Been; Jennifer L. Bolton; Lori L. Bonnycastle; Paolo Brambilla; Mary S. Burnett; Giancarlo Cesana; Maria Dimitriou; Alex S. F. Doney; Angela Doering; Paul Elliott; Stephen E. Epstein; Gudmundur Ingi Eyjolfsson; Bruna Gigante; Mark O. Goodarzi; Harald Grallert; Martha L. Gravito; Christopher J. Groves; Goran Hallmans; Anna-Liisa Hartikainen; Caroline Hayward; Dena Hernandez; Andrew A. Hicks; Hilma Holm; Yi-Jen Hung; Thomas Illig; Michelle R. Jones; Pontiano Kaleebu; John J. P. Kastelein; Kay-Tee Khaw

doi:10.1038/ng.2795

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Common variants associated with plasma triglycerides and risk for coronary artery disease

Journal article

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Common variants associated with plasma triglycerides and risk for coronary artery disease

Ron Do, Cristen J. Willer, Ellen M. Schmidt, Sebanti Sengupta, Chi Gao, Gina M. Peloso, Stefan Gustafsson, Stavroula Kanoni, Andrea Ganna, Jin Chen, …

Nature genetics, Vol.45(11), pp.1345-1352

01/11/2013

DOI: https://doi.org/10.1038/ng.2795

PMID: 24097064

Abstract

Genetics & Heredity

Life Sciences & Biomedicine

Science & Technology

Triglycerides are transported in plasma by specific triglyceride-rich lipoproteins; in epidemiological studies, increased triglyceride levels correlate with higher risk for coronary artery disease (CAD). However, it is unclear whether this association reflects causal processes. We used 185 common variants recently mapped for plasma lipids (P < 5 x 10(-8) for each) to examine the role of triglycerides in risk for CAD. First, we highlight loci associated with both low-density lipoprotein cholesterol (LDL-C) and triglyceride levels, and we show that the direction and magnitude of the associations with both traits are factors in determining CAD risk. Second, we consider loci with only a strong association with triglycerides and show that these loci are also associated with CAD. Finally, in a model accounting for effects on LDL-C and/or high-density lipoprotein cholesterol (HDL-C) levels, the strength of a polymorphism's effect on triglyceride levels is correlated with the magnitude of its effect on CAD risk. These results suggest that triglyceride-rich lipoproteins causally influence risk for CAD.

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Title: Common variants associated with plasma triglycerides and risk for coronary artery disease
Creators: Ron Do - Massachusetts General Hospital
Cristen J. Willer - Michigan Medicine
Ellen M. Schmidt - University of Michigan–Ann Arbor
Sebanti Sengupta - University of Michigan–Ann Arbor
Chi Gao - Center for Human Genetics
Gina M. Peloso - Center for Human Genetics
Stefan Gustafsson - Uppsala University
Stavroula Kanoni - Wellcome Sanger Institute
Andrea Ganna - Uppsala University
Jin Chen - University of Michigan–Ann Arbor
Martin L. Buchkovich - University of North Carolina at Chapel Hill
Samia Mora - Brigham and Women's Hospital
Jacques S. Beckmann - University of Lausanne
Jennifer L. Bragg-Gresham
Hsing-Yi Chang
Ayse Demirkan - Erasmus MC
Heleen M. Den Hertog - Erasmus MC
Louise A. Donnelly - Ninewells Hospital
Georg B. Ehret - University Hospital of Geneva
Tonu Esko - Broad Institute
Mary F. Feitosa - Washington University in St. Louis
Teresa Ferreira - Wellcome Centre for Human Genetics
Krista Fischer - University of Tartu
Pierre Fontanillas - Broad Institute
Ross M. Fraser - University of Edinburgh
Daniel F. Freitag - University of Cambridge
Deepti Gurdasani - Wellcome Sanger Institute
Kauko Heikkila - University of Helsinki
Elina Hyppoenen - Biostat
Aaron Isaacs - Erasmus MC
Anne U. Jackson - University of Michigan–Ann Arbor
Asa Johansson - Uppsala University
Toby Johnson - Queen Mary University of London
Marika Kaakinen - University of Oulu
Johannes Kettunen - University of Helsinki
Marcus E. Kleber - Universität Ulm
Xiaohui Li - Cedars-Sinai Medical Center
Jian'an Luan - Massachusetts Rehabilitation Commission
Leo-Pekka Lyytikainen - Tampere University
Patrik K. E. Magnusson - Karolinska Institutet
Massimo Mangino - King's College London
Evelin Mihailov - University of Tartu
May E. Montasser - University of Maryland, Baltimore
Martina Mueller-Nurasyid - Helmholtz Zentrum München
Ilja M. Nolte - University Medical Center Groningen
Jeffrey R. O'Connell - Supreme Council Of Health
Cameron D. Palmer - Childrens Hosp, Div Endocrinol, Boston, MA 02115 USA
Markus Perola - University of Tartu
Ann-Kristin Petersen - Helmholtz Zentrum München
Serena Sanna - Institute of Genetic and Biomedical Research
Richa Saxena - Center for Human Genetics
Susan K. Service - University of California, Los Angeles
Sonia Shah - University College London
Dmitry Shungin - Scania
Carlo Sidore - University of Michigan–Ann Arbor
Ci Song - Science for Life Laboratory
Rona J. Strawbridge - Karolinska Institutet
Ida Surakka - Institute for Molecular Medicine Finland
Toshiko Tanaka - National Institutes of Health Clinical Center
Tanya M. Teslovich - University of Michigan–Ann Arbor
Gudmar Thorleifsson - Amgen
Evita G. Van den Herik - Erasmus MC
Benjamin F. Voight - University of Pennsylvania
Kelly A. Volcik - The University of Texas Health Science Center at Houston
Lindsay L. Waite - HudsonAlpha Institute for Biotechnology
Andrew Wong - MRC Unit for Lifelong Health and Ageing
Ying Wu
Weihua Zhang - Imperial College London
Devin Absher - HudsonAlpha Institute for Biotechnology
Gershim Asiki - Uganda Virus Research Institute
Ines Barroso - Wellcome Sanger Institute
Latonya F. Been - University of Oklahoma Health Sciences Center
Jennifer L. Bolton - University of Edinburgh
Lori L. Bonnycastle - National Human Genome Research Institute
Paolo Brambilla - University of Milano-Bicocca
Mary S. Burnett - MedStar Health
Giancarlo Cesana - University of Milano-Bicocca
Maria Dimitriou - Harokopio University of Athens
Alex S. F. Doney - Ninewells Hospital
Angela Doering - Helmholtz Zentrum München
Paul Elliott - University of Oulu
Stephen E. Epstein - MedStar Health
Gudmundur Ingi Eyjolfsson - Lab Mjodd, Reykjavik, Iceland
Bruna Gigante - Karolinska Institutet
Mark O. Goodarzi - Cedars-Sinai Medical Center
Harald Grallert - Helmholtz Zentrum München
Martha L. Gravito - University of Oklahoma Health Sciences Center
Christopher J. Groves - Oxford Centre for Diabetes, Endocrinology and Metabolism
Goran Hallmans - Umeå University
Anna-Liisa Hartikainen - Oulu University Hospital
Caroline Hayward - MRC Institute of Genetics and Molecular Medicine
Dena Hernandez - National Institute on Aging
Andrew A. Hicks - Eurac Research
Hilma Holm - deCODE Genetics
Yi-Jen Hung - National Defense Medical Center
Thomas Illig - Helmholtz Zentrum München
Michelle R. Jones - College Station Medical Center
Pontiano Kaleebu - Uganda Virus Research Institute
John J. P. Kastelein - Academic Medical Center
Kay-Tee Khaw - University of Cambridge
Publication Details: Nature genetics, Vol.45(11), pp.1345-1352
Publisher: Springer Nature
Number of pages: 9
Date published: 01/11/2013
Grant note: Massachusetts General Hospital ES/J023299/1 / ESRC; UK Research & Innovation (UKRI); Economic & Social Research Council (ESRC) MC_U106188470; MC_U123092720; MR/K013491/1; MC_UU_12015/1; MC_U950080926; G0701863; G0901213; MC_UU_12015/2; G0801566; MR/K013351/1; MR/L003120/1; MC_U106179472 / MRC; UK Research & Innovation (UKRI); Medical Research Council UK (MRC) R01HL107816 / US National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA Donovan Family Foundation Fondation Leducq; Leducq Foundation T32HL007208 / National Heart, Lung, and Blood Institute; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) Canadian Institutes of Health Research; Canadian Institutes of Health Research (CIHR)
Identifiers: 99929025402346
Academic Unit: Institute for Sustainability; Surrey Institute for People-Centred AI; School of Biosciences
Language: English
Resource Type: Journal article

Common variants associated with plasma triglycerides and risk for coronary artery disease

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