Abstract
The triple-base-pair 16S rDNA mutation AGA
926-928
→TTC mediates high-level tetracycline resistance in
Helicobacter pylori
. In contrast, single- and double-base-pair mutations mediated only low-level tetracycline resistance and decreased growth rates in the presence of tetracycline, explaining the preference for the TTC mutation in tetracycline-resistant
H. pylori
isolates.