No Interactions Between Previously Associated 2-Hour Glucose Gene Variants and Physical Activity or BMI on 2-Hour Glucose Levels

Robert A. Scott; Audrey Y. Chu; Niels Grarup; Alisa K. Manning; Marie-France Hivert; Dmitry Shungin; Anke Toenjes; Ajay Yesupriya; Daniel Barnes; Nabila Bouatia-Naji; Nicole L. Glazer; Anne U. Jackson; Zoltan Kutalik; Vasiliki Lagou; Diana Marek; Laura J. Rasmussen-Torvik; Heather M. Stringham; Toshiko Tanaka; Mette Aadahl; Dan E. Arking; Sven Bergmann; Eric Boerwinkle; Lori L. Bonnycastle; Stefan R. Bornstein; Eric Brunner; Suzannah J. Bumpstead; Soren Brage; Olga D. Carlson; Han Chen; Yii-Der Ida Chen; Peter S. Chines; Francis S. Collins; David J. Couper; Elaine M. Dennison; Nicole F. Dowling; Josephine S. Egan; Ulf Ekelund; Michael R. Erdos; Nita G. Forouhi; Caroline S. Fox; Mark O. Goodarzi; Juergen Graessler; Stefan Gustafsson; Goeran Hallmans; Torben Hansen; Aroon Hingorani; John W. Holloway; Frank B. Hu; Bo Isomaa; Karen A. Jameson; Ingegerd Johansson; Anna Jonsson; Torben Jorgensen; Mika Kivimaki; Peter Kovacs; Meena Kumari; Johanna Kuusisto; Markku Laakso; Cecile Lecoeur; Claire Levy-Marchal; Guo Li; Ruth J. F. Loos; Valeri Lyssenko; Michael Marmot; Pedro Marques-Vidal; Mario A. Morken; Gabriele Mueller; Kari E. North; James S. Pankow; Felicity Payne; Inga Prokopenko; Bruce M. Psaty; Frida Renstrom; Ken Rice; Jerome I. Rotter; Denis Rybin; Camilla H. Sandholt; Avan A. Sayer; Peter Shrader; Peter E. H. Schwarz; David S. Siscovick; Alena Stancakova; Michael Stumvoll; Tanya M. Teslovich; Gerard Waeber; Gordon H. Williams; Daniel R. Witte; Andrew R. Wood; Weijia Xie; Michael Boehnke; Cyrus Cooper; Luigi Ferrucci; Philippe Froguel; Leif Groop; W. H. Linda Kao; Peter Vollenweider; Mark Walker; Richard M. Watanabe; Oluf Pedersen; James B. Meigs

doi:10.2337/db11-0973

Back

No Interactions Between Previously Associated 2-Hour Glucose Gene Variants and Physical Activity or BMI on 2-Hour Glucose Levels

Journal article

Open access

Peer reviewed

No Interactions Between Previously Associated 2-Hour Glucose Gene Variants and Physical Activity or BMI on 2-Hour Glucose Levels

Robert A. Scott, Audrey Y. Chu, Niels Grarup, Alisa K. Manning, Marie-France Hivert, Dmitry Shungin, Anke Toenjes, Ajay Yesupriya, Daniel Barnes, Nabila Bouatia-Naji, …

Diabetes (New York, N.Y.), Vol.61(5), pp.1291-1296

01/05/2012

DOI: https://doi.org/10.2337/db11-0973

PMID: 22415877

Abstract

Endocrinology & Metabolism

Life Sciences & Biomedicine

Science & Technology

Gene-lifestyle interactions have been suggested to contribute to the development of type 2 diabetes. Glucose levels 2 h after a standard 75-g glucose challenge are used to diagnose diabetes and are associated with both genetic and lifestyle factors. However, whether these factors interact to determine 2-h glucose levels is unknown. We meta-analyzed single nucleotide polymorphism (SNP) X BMI and SNP x physical activity (PA) interaction regression models for five SNPs previously associated with 2-h glucose levels from up to 22 studies comprising 54,884 individuals without diabetes. PA levels were dichotomized, with individuals below the first quintile classified as inactive (20%) and the remainder as active (80%). BMI was considered a continuous trait. Inactive individuals had higher 2-h glucose levels than active individuals (beta = 0.22 mmol/L [95% CI 0.13-0.31], P = 1.63 X 10(-6)). All SNPs were associated with 2-h glucose (beta = 0.06-0.12 mmol/allele, P <= 1.53 X 10(-7)), but no significant interactions were found with PA (P > 0.18) or BMI (P >= 0.04). In this large study of gene-lifestyle interaction, we observed no interactions between genetic and lifestyle factors, both of which were associated with 2-h glucose. It is perhaps unlikely that top loci from genome-wide association studies will exhibit strong subgroup-specific effects, and may not, therefore, make the best candidates for the study of interactions. Diabetes 61:1291-1296, 2012

Files and links (1)

url

https://doi.org/10.2337/db11-0973View

Published (Version of record) Open

Metrics

2 Record Views

19 Times Cited - Web of Science

Details

Title: No Interactions Between Previously Associated 2-Hour Glucose Gene Variants and Physical Activity or BMI on 2-Hour Glucose Levels
Creators: Robert A. Scott - Medical Research Council
Audrey Y. Chu - Brigham and Women's Hospital
Niels Grarup - Novo Nordisk Foundation
Alisa K. Manning - Boston University
Marie-France Hivert - College Station Medical Center
Dmitry Shungin - Umeå University
Anke Toenjes - College Station Medical Center
Ajay Yesupriya - Centers for Disease Control and Prevention
Daniel Barnes - MRC Epidemiology Unit
Nabila Bouatia-Naji - Inst Pasteur, CNRS, UMR 8199, F-59019 Lille, France
Nicole L. Glazer - Boston University
Anne U. Jackson - University of Michigan–Ann Arbor
Zoltan Kutalik - SIB Swiss Institute of Bioinformatics
Vasiliki Lagou - Wellcome Centre for Human Genetics
Diana Marek - University of Lausanne
Laura J. Rasmussen-Torvik - Northwestern University
Heather M. Stringham - University of Michigan–Ann Arbor
Toshiko Tanaka - National Institute on Aging
Mette Aadahl - Glostrup Hospital
Dan E. Arking - Johns Hopkins University
Sven Bergmann - University of Lausanne
Eric Boerwinkle - The University of Texas Health Science Center at Houston
Lori L. Bonnycastle - National Human Genome Research Institute
Stefan R. Bornstein - University Hospital Carl Gustav Carus
Eric Brunner - University College London
Suzannah J. Bumpstead - Wellcome Sanger Institute
Soren Brage - Massachusetts Rehabilitation Commission
Olga D. Carlson - National Institute on Aging
Han Chen - Boston University
Yii-Der Ida Chen - College Station Medical Center
Peter S. Chines - National Human Genome Research Institute
Francis S. Collins - National Human Genome Research Institute
David J. Couper - University of North Carolina at Chapel Hill
Elaine M. Dennison - MRC Lifecourse Epidemiology Unit
Nicole F. Dowling - Office of Public Health Genomics
Josephine S. Egan - National Institute on Aging
Ulf Ekelund - MRC Epidemiology Unit
Michael R. Erdos - National Human Genome Research Institute
Nita G. Forouhi - MRC Epidemiology Unit
Caroline S. Fox - Brigham and Women's Hospital
Mark O. Goodarzi - Cedars-Sinai Medical Center
Juergen Graessler - College Station Medical Center
Stefan Gustafsson - Karolinska Institutet
Goeran Hallmans - Umeå University
Torben Hansen - Novo Nordisk Foundation
Aroon Hingorani - University College London
John W. Holloway - University of Southampton
Frank B. Hu - Harvard University
Bo Isomaa - Folkhälsans Forskningscentrum
Karen A. Jameson - MRC Lifecourse Epidemiology Unit
Ingegerd Johansson - Umeå University
Anna Jonsson - Lund University
Torben Jorgensen - Glostrup Univ Hosp, Res Ctr Prevent & Hlth, Glostrup, Denmark
Mika Kivimaki - University College London
Peter Kovacs - Leipzig University
Meena Kumari - University College London
Johanna Kuusisto - Kuopio University Hospital
Markku Laakso - University of Eastern Finland
Cecile Lecoeur - Inst Pasteur, CNRS, UMR 8199, F-59019 Lille, France
Claire Levy-Marchal - Université de Lille
Guo Li - University of Washington
Ruth J. F. Loos - MRC Epidemiology Unit
Valeri Lyssenko - Lund University
Michael Marmot - University College London
Pedro Marques-Vidal - Charmo University
Mario A. Morken - National Human Genome Research Institute
Gabriele Mueller - College Station Medical Center
Kari E. North - University of North Carolina at Chapel Hill
James S. Pankow - University of Minnesota
Felicity Payne - Wellcome Sanger Institute
Inga Prokopenko - Wellcome Centre for Human Genetics
Bruce M. Psaty - University of Washington
Frida Renstrom - Lund University
Ken Rice - University of Washington
Jerome I. Rotter - Cedars-Sinai Medical Center
Denis Rybin - Boston University
Camilla H. Sandholt - Novo Nordisk Foundation
Avan A. Sayer - University of Southampton
Peter Shrader - Massachusetts General Hospital
Peter E. H. Schwarz - College Station Medical Center
David S. Siscovick - University of Washington
Alena Stancakova - Kuopio University Hospital
Michael Stumvoll - Leipzig University
Tanya M. Teslovich - University of Michigan–Ann Arbor
Gerard Waeber - Charmo University
Gordon H. Williams - Brigham and Women's Hospital
Daniel R. Witte - Steno Diabetes Center
Andrew R. Wood - Peninsula College of Medicine and Dentistry
Weijia Xie - Peninsula College of Medicine and Dentistry
Michael Boehnke - University of Michigan–Ann Arbor
Cyrus Cooper - University of Southampton
Luigi Ferrucci - National Institute on Aging
Philippe Froguel - Imperial College London
Leif Groop - Lund University
W. H. Linda Kao - Johns Hopkins University
Peter Vollenweider - Charmo University
Mark Walker - Newcastle University
Richard M. Watanabe - University of Southern California
Oluf Pedersen - University of Copenhagen
James B. Meigs - Harvard University
Publication Details: Diabetes (New York, N.Y.), Vol.61(5), pp.1291-1296
Publisher: Amer Diabetes Assoc
Number of pages: 6
Date published: 01/05/2012
Grant note: MC_UP_A620_1015; G0902037; G0701863; MC_UP_A100_1003; G1002084; MC_U106179473 / MRC; UK Research & Innovation (UKRI); Medical Research Council UK (MRC) RG/07/008/23674 / British Heart Foundation G0701863; MC_UP_A620_1014; U1475000002; G8802774; MC_U106179473; G0100222; G0600717B; MC_UP_A620_1015; G19/35; MC_UP_A100_1003; U1475000001; G0902037; G1002084; MC_U147585824; MC_U106179471 / Medical Research Council; UK Research & Innovation (UKRI); Medical Research Council UK (MRC) NNF11OC1014855 / Novo Nordisk Fonden; Novo Nordisk Foundation NF-SI-0508-10082 / National Institute for Health Research; National Institutes of Health Research (NIHR)
Identifiers: 99928815802346
Academic Unit: School of Biosciences
Language: English
Resource Type: Journal article

No Interactions Between Previously Associated 2-Hour Glucose Gene Variants and Physical Activity or BMI on 2-Hour Glucose Levels

Abstract

Files and links (1)

Metrics

Details

Usage Policy