Breast Cancer Risk and 6q22.33: Combined Results from Breast Cancer Association Consortium and Consortium of Investigators on Modifiers of BRCA1/2

Tomas Kirchhoff; Mia M. Gaudet; Antonis C. Antoniou; Lesley McGuffog; Manjeet K. Humphreys; Alison M. Dunning; Stig E. Bojesen; Borge G. Nordestgaard; Henrik Flyger; Daehee Kang; Keun-Young Yoo; Dong-Young Noh; Sei-Hyun Ahn; Thilo Dork; Peter Schuermann; Johann H. Karstens; Peter Hillemanns; Fergus J. Couch; Janet Olson; Celine Vachon; Xianshu Wang; Angela Cox; Ian Brock; Graeme Elliott; Malcolm W. R. Reed; Barbara Burwinkel; Alfons Meindl; Hiltrud Brauch; Ute Hamann; Yon-Dschun Ko; Annegien Broeks; Marjanka K. Schmidt; Laura J. Van 't Veer; Linde M. Braaf; Nichola Johnson; Olivia Fletcher; Lorna Gibson; Julian Peto; Clare Turnbull; Sheila Seal; Anthony Renwick; Nazneen Rahman; Pei-Ei Wu; Jyh-Cherng Yu; Chia-Ni Hsiung; Chen-Yang Shen; Melissa C. Southey; John L. Hopper; Fleur Hammet; Thijs Van Dorpe; Anne-Sophie Dieudonne; Sigrid Hatse; Diether Lambrechts; Irene L. Andrulis; Natalia Bogdanova; Natalia Antonenkova; Juri I. Rogov; Daria Prokofieva; Marina Bermisheva; Elza Khusnutdinova; Christi J. van Asperen; Robert A. E. M. Tollenaar; Maartje J. Hooning; Peter Devilee; Sara Margolin; Annika Lindblom; Roger L. Milne; Jose Ignacio Arias; M. Pilar Zamora; Javier Benitez; Gianluca Severi; Laura Baglietto; Graham G. Giles; Amanda B. Spurdle; Jonathan Beesley; Xiaoqing Chen; Helene Holland; Sue Healey; Shan Wang-Gohrke; Jenny Chang-Claude; Arto Mannermaa; Veli-Matti Kosma; Jaana Kauppinen; Vesa Kataja; Bjarni A. Agnarsson; Maria A. Caligo; Andrew K. Godwin; Heli Nevanlinna; Tuomas Heikkinen; Zachary Fredericksen; Noralane Lindor; Katherine L. Nathanson; Susan M. Domchek; Niklas Loman; Per Karlsson; Marie Stenmark Askmalm; Beatrice Melin; Anna von Wachenfeldt; Frans B. L. Hogervorst; Martijn Verheus; EMBRACE; Christine June Jacobs

doi:10.1371/journal.pone.0035706

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Breast Cancer Risk and 6q22.33: Combined Results from Breast Cancer Association Consortium and Consortium of Investigators on Modifiers of BRCA1/2

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Breast Cancer Risk and 6q22.33: Combined Results from Breast Cancer Association Consortium and Consortium of Investigators on Modifiers of BRCA1/2

Tomas Kirchhoff, Mia M. Gaudet, Antonis C. Antoniou, Lesley McGuffog, Manjeet K. Humphreys, Alison M. Dunning, Stig E. Bojesen, Borge G. Nordestgaard, Henrik Flyger, Daehee Kang, …

PloS one, Vol.7(6), pp.e35706-e35706

29/06/2012

DOI: https://doi.org/10.1371/journal.pone.0035706

PMID: 22768030

Abstract

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Recently, a locus on chromosome 6q22.33 (rs2180341) was reported to be associated with increased breast cancer risk in the Ashkenazi Jewish (AJ) population, and this association was also observed in populations of non-AJ European ancestry. In the present study, we performed a large replication analysis of rs2180341 using data from 31,428 invasive breast cancer cases and 34,700 controls collected from 25 studies in the Breast Cancer Association Consortium (BCAC). In addition, we evaluated whether rs2180341 modifies breast cancer risk in 3,361 BRCA1 and 2,020 BRCA2 carriers from 11 centers in the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA). Based on the BCAC data from women of European ancestry, we found evidence for a weak association with breast cancer risk for rs2180341 (per-allele odds ratio (OR) = 1.03, 95% CI 1.00-1.06, p = 0.023). There was evidence for heterogeneity in the ORs among studies (I-2 = 49.3%; p = <0.004). In CIMBA, we observed an inverse association with the minor allele of rs2180341 and breast cancer risk in BRCA1 mutation carriers (per-allele OR = 0.89, 95% CI 0.80-1.00, p = 0.048), indicating a potential protective effect of this allele. These data suggest that that 6q22.33 confers a weak effect on breast cancer risk.

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Title: Breast Cancer Risk and 6q22.33: Combined Results from Breast Cancer Association Consortium and Consortium of Investigators on Modifiers of BRCA1/2
Creators: Tomas Kirchhoff - American Cancer Society
Mia M. Gaudet - American Cancer Society
Antonis C. Antoniou - University of Cambridge
Lesley McGuffog - University of Cambridge
Manjeet K. Humphreys - University of Cambridge
Alison M. Dunning - University of Cambridge
Stig E. Bojesen - Herlev Hospital
Borge G. Nordestgaard - University of Copenhagen
Henrik Flyger - Herlev Hospital
Daehee Kang - Seoul National University
Keun-Young Yoo - Seoul National University
Dong-Young Noh - University of Ulsan
Sei-Hyun Ahn - University of Ulsan
Thilo Dork - Medizinische Hochschule Hannover
Peter Schuermann - Supreme Council Of Health
Johann H. Karstens - Supreme Council Of Health
Peter Hillemanns - Medizinische Hochschule Hannover
Fergus J. Couch - Mayo Clinic
Janet Olson - Mayo Clinic in Florida
Celine Vachon - Mayo Clinic in Florida
Xianshu Wang - Mayo Clinic in Florida
Angela Cox - University of Sheffield
Ian Brock - University of Sheffield
Graeme Elliott - University of Sheffield
Malcolm W. R. Reed - University of Sheffield
Barbara Burwinkel - Technical University of Munich
Alfons Meindl - Ludwig-Maximilians-Universität München
Hiltrud Brauch - University of Bonn
Ute Hamann - DKFZ-ZMBH Alliance
Yon-Dschun Ko - College Station Medical Center
Annegien Broeks - The Netherlands Cancer Institute
Marjanka K. Schmidt - The Netherlands Cancer Institute
Laura J. Van 't Veer - Netherlands Canc Inst, ABCS, Dept Expt Therapy, Amsterdam, Netherlands
Linde M. Braaf - The Netherlands Cancer Institute
Nichola Johnson - Breast Cancer Now
Olivia Fletcher - London School of Hygiene & Tropical Medicine
Lorna Gibson - Institute of Cancer Research
Julian Peto - London School of Hygiene & Tropical Medicine
Clare Turnbull - Institute of Cancer Research
Sheila Seal - Institute of Cancer Research
Anthony Renwick - Institute of Cancer Research
Nazneen Rahman - Institute of Cancer Research
Pei-Ei Wu - Institute of Biomedical Sciences, Academia Sinica
Jyh-Cherng Yu - Institute of Biomedical Sciences, Academia Sinica
Chia-Ni Hsiung - Acad Sinica, Inst Biomed Sci, Taiwanese Breast Canc Study TWBCS, Taipei, Taiwan
Chen-Yang Shen - Acad Sinica, Inst Biomed Sci, Taiwanese Breast Canc Study TWBCS, Taipei, Taiwan
Melissa C. Southey - University of Melbourne
John L. Hopper - University of Melbourne
Fleur Hammet - University of Melbourne
Thijs Van Dorpe - KU Leuven
Anne-Sophie Dieudonne - KU Leuven
Sigrid Hatse - KU Leuven
Diether Lambrechts - KU Leuven
Irene L. Andrulis - University of Toronto
Natalia Bogdanova - N.N. Alexandrov National Cancer Centre
Natalia Antonenkova - N.N. Alexandrov National Cancer Centre
Juri I. Rogov - N.N. Alexandrov National Cancer Centre
Daria Prokofieva - Institute of Biochemistry and Genetics of Ufa Scientific Centre
Marina Bermisheva - Institute of Biochemistry and Genetics of Ufa Scientific Centre
Elza Khusnutdinova - UFA
Christi J. van Asperen - Leiden University Medical Center
Robert A. E. M. Tollenaar - Leiden University Medical Center
Maartje J. Hooning - Leiden University Medical Center
Peter Devilee - Leiden University Medical Center
Sara Margolin - Karolinska Univ, Stockholm, Sweden
Annika Lindblom - Karolinska Institutet
Roger L. Milne - Hospital Monte Naranco
Jose Ignacio Arias - Monte Naranco Hosp, Oviedo, Spain
M. Pilar Zamora - La Paz Univ Hosp, Madrid, Spain
Javier Benitez - Spanish National Cancer Research Centre
Gianluca Severi - Cancer Council Victoria
Laura Baglietto - Cancer Council Victoria
Graham G. Giles - University of Melbourne
Amanda B. Spurdle - Peter MacCallum Cancer Centre
Jonathan Beesley - QIMR Berghofer Medical Research Institute
Xiaoqing Chen - College Station Medical Center
Helene Holland - QIMR Berghofer Medical Research Institute
Sue Healey - QIMR Berghofer Medical Research Institute
Shan Wang-Gohrke - Universität Ulm
Jenny Chang-Claude - Heidelberg
Arto Mannermaa - University of Eastern Finland
Veli-Matti Kosma - Vaasa Central Hospital
Jaana Kauppinen - Vaasa Central Hospital
Vesa Kataja - University of Eastern Finland
Bjarni A. Agnarsson - National University Hospital of Iceland
Maria A. Caligo - University of Pisa
Andrew K. Godwin - Fox Chase Cancer Center
Heli Nevanlinna - Helsinki University Hospital
Tuomas Heikkinen - Helsinki University Hospital
Zachary Fredericksen - Mayo Clinic
Noralane Lindor - Mayo Clinic
Katherine L. Nathanson - University of Pennsylvania
Susan M. Domchek - University of Pennsylvania
Niklas Loman - Lund University
Per Karlsson - Sahlgrenska University Hospital
Marie Stenmark Askmalm - Sahlgrenska University Hospital
Beatrice Melin - Umeå University
Anna von Wachenfeldt - Umeå University
Frans B. L. Hogervorst - The Netherlands Cancer Institute
Martijn Verheus - Erasmus MC
EMBRACE
Christine June Jacobs - School of Health Sciences
Publication Details: PloS one, Vol.7(6), pp.e35706-e35706
Publisher: Public Library Science
Number of pages: 10
Date published: 29/06/2012
Grant note: 10124 / The Francis Crick Institute; Cancer Research UK; Cancer Research UK G0700491; GRANTS:15410934 / MRC; UK Research & Innovation (UKRI); Medical Research Council UK (MRC) G0700491; GRANTS:14917119 / Medical Research Council; UK Research & Innovation (UKRI); Medical Research Council UK (MRC) GRANTS:14878105 / The Francis Crick Institute; Cancer Research UK; Cancer Research UK 15007; GRANTS:14894049; 10118; GRANTS:14916959; GRANTS:14930796; 11174; GRANTS:14928598; 15106; GRANTS:14923343; 11022 / Cancer Research UK
Identifiers: 99928805102346
Academic Unit: School of Health Sciences
Language: English
Resource Type: Journal article

Breast Cancer Risk and 6q22.33: Combined Results from Breast Cancer Association Consortium and Consortium of Investigators on Modifiers of BRCA1/2

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