Six new loci associated with body mass index highlight a neuronal influence on body weight regulation

Cristen J. Willer; Elizabeth K. Speliotes; Ruth J. F. Loos; Shengxu Li; Cecilia M. Lindgren; Iris M. Heid; Sonja I. Berndt; Amanda L. Elliott; Anne U. Jackson; Claudia Lamina; Guillaume Lettre; Noha Lim; Helen N. Lyon; Steven A. McCarroll; Konstantinos Papadakis; Lu Qi; Joshua C. Randall; Rosa Maria Roccasecca; Serena Sanna; Paul Scheet; Michael N. Weedon; Eleanor Wheeler; Jing Hua Zhao; Leonie C. Jacobs; Inga Prokopenko; Nicole Soranzo; Toshiko Tanaka; Nicholas J. Timpson; Peter Almgren; Amanda Bennett; Richard N. Bergman; Sheila A. Bingham; Lori L. Bonnycastle; Morris Brown; Noel L. P. Burtt; Peter Chines; Lachlan Coin; Francis S. Collins; John M. Connell; Cyrus Cooper; George Davey Smith; Elaine M. Dennison; Parimal Deodhar; Paul Elliott; Michael R. Erdos; Karol Estrada; David M. Evans; Lauren Gianniny; Christian Gieger; Christopher J. Gillson; Candace Guiducci; Rachel Hackett; David Hadley; Alistair S. Hall; Aki S. Havulinna; Johannes Hebebrand; Albert Hofman; Bo Isomaa; Kevin B. Jacobs; Toby Johnson; Pekka Jousilahti; Zorica Jovanovic; Kay-Tee Khaw; Peter Kraft; Mikko Kuokkanen; Johanna Kuusisto; Jaana Laitinen; Edward G. Lakatta; Jian'an Luan; Robert N. Luben; Massimo Mangino; Wendy L. McArdle; Thomas Meitinger; Antonella Mulas; Patricia B. Munroe; Narisu Narisu; Andrew R. Ness; Kate Northstone; Stephen O'Rahilly; Carolin Purmann; Matthew G. Rees; Martin Ridderstrale; Susan M. Ring; Fernando Rivadeneira; Aimo Ruokonen; Manjinder S. Sandhu; Jouko Saramies; Laura J. Scott; Angelo Scuteri; Kaisa Silander; Matthew A. Sims; Kijoung Song; Jonathan Stephens; Suzanne Stevens; Heather M. Stringham; Y. C. Loraine Tung; Timo T. Valle; Cornelia M. Van Duijn; Karani S. Vimaleswaran; Peter Vollenweider; Wellcome Trust Case Control

doi:10.1038/ng.287

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Six new loci associated with body mass index highlight a neuronal influence on body weight regulation

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Six new loci associated with body mass index highlight a neuronal influence on body weight regulation

Cristen J. Willer, Elizabeth K. Speliotes, Ruth J. F. Loos, Shengxu Li, Cecilia M. Lindgren, Iris M. Heid, Sonja I. Berndt, Amanda L. Elliott, Anne U. Jackson, Claudia Lamina, …

Nature genetics, Vol.41(1), pp.25-34

01/01/2009

DOI: https://doi.org/10.1038/ng.287

PMID: 19079261

Abstract

Genetics & Heredity

Life Sciences & Biomedicine

Science & Technology

Common variants at only two loci, FTO and MC4R, have been reproducibly associated with body mass index (BMI) in humans. To identify additional loci, we conducted meta-analysis of 15 genome-wide association studies for BMI (n > 32,000) and followed up top signals in 14 additional cohorts (n > 59,000). We strongly confirm FTO and MC4R and identify six additional loci (P < 5 x 10(-8)): TMEM18, KCTD15, GNPDA2, SH2B1, MTCH2 and NEGR1 (where a 45-kb deletion polymorphism is a candidate causal variant). Several of the likely causal genes are highly expressed or known to act in the central nervous system (CNS), emphasizing, as in rare monogenic forms of obesity, the role of the CNS in predisposition to obesity.

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Title: Six new loci associated with body mass index highlight a neuronal influence on body weight regulation
Creators: Cristen J. Willer - Biostat
Elizabeth K. Speliotes - Massachusetts Institute of Technology
Ruth J. F. Loos - Massachusetts Rehabilitation Commission
Shengxu Li - Massachusetts Rehabilitation Commission
Cecilia M. Lindgren - University of Oxford
Iris M. Heid - Helmholtz Zentrum München
Sonja I. Berndt - National Institutes of Health
Amanda L. Elliott - Broad Institute
Anne U. Jackson - University of Michigan–Ann Arbor
Claudia Lamina
Guillaume Lettre - Broad Institute
Noha Lim
Helen N. Lyon - Massachusetts Institute of Technology
Steven A. McCarroll - Broad Institute
Konstantinos Papadakis - St George's, University of London
Lu Qi - Harvard University Press
Joshua C. Randall - University of Oxford
Rosa Maria Roccasecca - Wellcome Sanger Institute
Serena Sanna - National Academies of Sciences, Engineering, and Medicine
Paul Scheet - Ann Arbor Center for Independent Living
Michael N. Weedon - Supreme Council Of Health
Eleanor Wheeler - Wellcome Sanger Institute
Jing Hua Zhao - Massachusetts Rehabilitation Commission
Leonie C. Jacobs - Erasmus University Rotterdam
Inga Prokopenko - University of Oxford
Nicole Soranzo - King's College London
Toshiko Tanaka - National Institutes of Health
Nicholas J. Timpson - University of Bristol
Peter Almgren - Lund University
Amanda Bennett - Broad Institute
Richard N. Bergman - University of Southern California
Sheila A. Bingham - Wellcome Trust
Lori L. Bonnycastle - National Institutes of Health
Morris Brown - University of Cambridge
Noel L. P. Burtt - Broad Institute
Peter Chines - National Institutes of Health
Lachlan Coin - Imperial College London
Francis S. Collins - National Institutes of Health
John M. Connell - University of Glasgow
Cyrus Cooper - University of Southampton
George Davey Smith - University of Bristol
Elaine M. Dennison - University of Southampton
Parimal Deodhar - National Institutes of Health
Paul Elliott - Imperial College London
Michael R. Erdos - National Institutes of Health
Karol Estrada - Erasmus University Rotterdam
David M. Evans - University of Bristol
Lauren Gianniny - Broad Institute
Christian Gieger - Helmholtz Zentrum München
Christopher J. Gillson - Massachusetts Rehabilitation Commission
Candace Guiducci - Broad Institute
Rachel Hackett - Broad Institute
David Hadley - St George's, University of London
Alistair S. Hall - Leeds General Infirmary
Aki S. Havulinna - Finnish Institute for Health and Welfare
Johannes Hebebrand - University of Duisburg-Essen
Albert Hofman - Erasmus University Rotterdam
Bo Isomaa - Malmska Municipal Hlth Ctr & Hosp, Folkhalsan Res Ctr, FIN-00014 Helsinki, Finland
Kevin B. Jacobs - Bioinformed Consulting Serv, Gaithersburg, MD 20877 USA
Toby Johnson - SIB Swiss Institute of Bioinformatics
Pekka Jousilahti - Finnish Institute for Health and Welfare
Zorica Jovanovic - University of Cambridge
Kay-Tee Khaw - University of Cambridge
Peter Kraft - Harvard University Press
Mikko Kuokkanen - Broad Institute
Johanna Kuusisto - University of Eastern Finland
Jaana Laitinen - Finnish Inst Occupat Hlth, FIN-90220 Oulu, Finland
Edward G. Lakatta - National Institutes of Health
Jian'an Luan - Massachusetts Rehabilitation Commission
Robert N. Luben - University of Cambridge
Massimo Mangino - University of Leicester
Wendy L. McArdle - University of Bristol
Thomas Meitinger - Technical University of Munich
Antonella Mulas - National Academies of Sciences, Engineering, and Medicine
Patricia B. Munroe - Queen Mary University of London
Narisu Narisu - National Institutes of Health
Andrew R. Ness - University of Bristol
Kate Northstone - University of Bristol
Stephen O'Rahilly - University of Cambridge
Carolin Purmann - University of Cambridge
Matthew G. Rees - National Institutes of Health
Martin Ridderstrale - Lund University
Susan M. Ring - University of Bristol
Fernando Rivadeneira - Erasmus University Rotterdam
Aimo Ruokonen - University of Oulu
Manjinder S. Sandhu - University of Cambridge
Jouko Saramies - Savitaipale Hlth Ctr, FIN-54800 Savitaipale, Finland
Laura J. Scott - University of Michigan–Ann Arbor
Angelo Scuteri - Ist Nazl Ricovero & Cura Anziani, Unita Operat Geriatria, I-00189 Rome, Italy
Kaisa Silander - Finnish Institute for Health and Welfare
Matthew A. Sims - Massachusetts Rehabilitation Commission
Kijoung Song
Jonathan Stephens - NHS Blood and Transplant
Suzanne Stevens - University of Leicester
Heather M. Stringham - University of Michigan–Ann Arbor
Y. C. Loraine Tung - University of Cambridge
Timo T. Valle - Finnish Institute for Health and Welfare
Cornelia M. Van Duijn - Erasmus University Rotterdam
Karani S. Vimaleswaran - University of Cambridge
Peter Vollenweider - University of Lausanne
Wellcome Trust Case Control
Publication Details: Nature genetics, Vol.41(1), pp.25-34
Publisher: Springer Nature
Number of pages: 10
Date published: 01/01/2009
Grant note: 090532; 068545/Z/02; 077016; 089061; 076113; 076467/Z/05/Z; 079557; 077011; 082390 / Wellcome Trust; European Commission Z01HG000024 / NATIONAL HUMAN GENOME RESEARCH INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Human Genome Research Institute (NHGRI) T32 DK007191; R56 DK062370; R01 DK075787; DK072193; F32 DK079466; U01 DK062370; DK075787; K23 DK080145; DK062370; R01 DK072193; K23 DK080145-01; R01 DK062370; F32 DK079466-01; K23 DK067288; R01 DK029867; T32DK07191 / NIDDK NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) N01-AG-1-2109 / NIA NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Aging (NIA) NF-SI-0508-10082 / National Institute for Health Research; National Institute for Health Research (NIHR) R01HL087679 / NATIONAL HEART, LUNG, AND BLOOD INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) U01 CA098233; U01 CA049449; R01 CA065725; R01 CA050385; 5UO1CA098233; U01 CA067262; CA87969; CA67262; CA65725; R01 CA067262; R01 CA049449; CA50385; CA49449; P01 CA087969 / NCI NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI) U1475000001 / Medical Research Council; UK Research & Innovation (UKRI); Medical Research Council UK (MRC); European Commission HG02651; 01-HG-65403; R01 HG002651; N01HG65403; 1Z01 HG000024 / NHGRI NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Human Genome Research Institute (NHGRI) P01CA087969 / NATIONAL CANCER INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI)
Identifiers: 99928776502346
Academic Unit: School of Biosciences
Language: English
Resource Type: Journal article

Six new loci associated with body mass index highlight a neuronal influence on body weight regulation

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