Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index

Elizabeth K. Speliotes; Cristen J. Willer; Sonja I. Berndt; Keri L. Monda; Gudmar Thorleifsson; Anne U. Jackson; Hana Lango Allen; Cecilia M. Lindgren; Jian'an Luan; Reedik Maegi; Joshua C. Randall; Sailaja Vedantam; Thomas W. Winkler; Lu Qi; Tsegaselassie Workalemahu; Iris M. Heid; Valgerdur Steinthorsdottir; Heather M. Stringham; Michael N. Weedon; Eleanor Wheeler; Andrew R. Wood; Teresa Ferreira; Robert J. Weyant; Ayellet V. Segre; Karol Estrada; Liming Liang; James Nemesh; Ju-Hyun Park; Stefan Gustafsson; Tuomas O. Kilpelaenen; Jian Yang; Nabila Bouatia-Naji; Tonu Esko; Mary F. Feitosa; Zoltan Kutalik; Massimo Mangino; Soumya Raychaudhuri; Andre Scherag; Albert Vernon Smith; Ryan Welch; Jing Hua Zhao; Katja K. Aben; Devin M. Absher; Najaf Amin; Anna L. Dixon; Eva Fisher; Nicole L. Glazer; Michael E. Goddard; Nancy L. Heard-Costa; Volker Hoesel; Jouke-Jan Hottenga; Asa Johansson; Toby Johnson; Shamika Ketkar; Claudia Lamina; Shengxu Li; Miriam F. Moffatt; Richard H. Myers; Narisu Narisu; John R. B. Perry; Marjolein J. Peters; Michael Preuss; Samuli Ripatti; Fernando Rivadeneira; Camilla Sandholt; Laura J. Scott; Nicholas J. Timpson; Jonathan P. Tyrer; Sophie van Wingerden; Richard M. Watanabe; Charles C. White; Fredrik Wiklund; Christina Barlassina; Daniel I. Chasman; Matthew N. Cooper; John-Olov Jansson; Robert W. Lawrence; Niina Pellikka; Inga Prokopenko; Jianxin Shi; Elisabeth Thiering; Helene Alavere; Maria T. S. Alibrandi; Peter Almgren; Alice M. Arnold; Thor Aspelund; Larry D. Atwood; Beverley Balkau; Anthony J. Balmforth; Amanda J. Bennett; Yoav Ben-Shlomo; Richard N. Bergman; Sven Bergmann; Heike Biebermann; Alexandra I. F. Blakemore; Tanja Boes; Lori L. Bonnycastle; Stefan R. Bornstein; Morris J. Brown; Thomas A. Buchanan; MAGIC

doi:10.1038/ng.686

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Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index

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Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index

Elizabeth K. Speliotes, Cristen J. Willer, Sonja I. Berndt, Keri L. Monda, Gudmar Thorleifsson, Anne U. Jackson, Hana Lango Allen, Cecilia M. Lindgren, Jian'an Luan, Reedik Maegi, …

Nature genetics, Vol.42(11), pp.937-U53

01/11/2010

DOI: https://doi.org/10.1038/ng.686

PMID: 20935630

Abstract

Genetics & Heredity

Life Sciences & Biomedicine

Science & Technology

Obesity is globally prevalent and highly heritable, but its underlying genetic factors remain largely elusive. To identify genetic loci for obesity susceptibility, we examined associations between body mass index and similar to 2.8 million SNPs in up to 123,865 individuals with targeted follow up of 42 SNPs in up to 125,931 additional individuals. We confirmed 14 known obesity susceptibility loci and identified 18 new loci associated with body mass index (P < 5 x 10(-8)), one of which includes a copy number variant near GPRC5B. Some loci (at MC4R, POMC, SH2B1 and BDNF) map near key hypothalamic regulators of energy balance, and one of these loci is near GIPR, an incretin receptor. Furthermore, genes in other newly associated loci may provide new insights into human body weight regulation.

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Title: Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index
Creators: Elizabeth K. Speliotes - Broad Institute
Cristen J. Willer - University of Michigan–Ann Arbor
Sonja I. Berndt - National Cancer Institute
Keri L. Monda - University of North Carolina at Chapel Hill
Gudmar Thorleifsson - deCODE Genet, Reykjavik, Iceland
Anne U. Jackson - University of Michigan–Ann Arbor
Hana Lango Allen - University of Exeter
Cecilia M. Lindgren - University of Oxford
Jian'an Luan - Massachusetts Rehabilitation Commission
Reedik Maegi - University of Oxford
Joshua C. Randall - Wellcome Centre for Human Genetics
Sailaja Vedantam - Broad Institute
Thomas W. Winkler - University of Regensburg
Lu Qi - Harvard University
Tsegaselassie Workalemahu - Harvard University
Iris M. Heid - University of Regensburg
Valgerdur Steinthorsdottir - deCODE Genet, Reykjavik, Iceland
Heather M. Stringham - University of Michigan–Ann Arbor
Michael N. Weedon - University of Exeter
Eleanor Wheeler - Wellcome Sanger Institute
Andrew R. Wood - University of Exeter
Teresa Ferreira - Wellcome Centre for Human Genetics
Robert J. Weyant - University of Michigan–Ann Arbor
Ayellet V. Segre - Center for Human Genetics
Karol Estrada - Erasmus MC
Liming Liang - Harvard University
James Nemesh - Broad Institute
Ju-Hyun Park - National Institutes of Health
Stefan Gustafsson - Karolinska Institutet
Tuomas O. Kilpelaenen - Massachusetts Rehabilitation Commission
Jian Yang - QIMR Berghofer Medical Research Institute
Nabila Bouatia-Naji - Inst Pasteur, CNRS, UMR8199, IBL, F-59019 Lille, France
Tonu Esko - University of Tartu
Mary F. Feitosa - Washington University in St. Louis
Zoltan Kutalik - University of Lausanne
Massimo Mangino - King's College London
Soumya Raychaudhuri - Broad Institute
Andre Scherag - University of Duisburg-Essen
Albert Vernon Smith - Icelandic Heart Association
Ryan Welch - University of Michigan–Ann Arbor
Jing Hua Zhao - Massachusetts Rehabilitation Commission
Katja K. Aben - Netherlands Comprehensive Cancer Organisation
Devin M. Absher - HudsonAlpha Institute for Biotechnology
Najaf Amin - Erasmus MC
Anna L. Dixon - University of Bath
Eva Fisher - German Institute of Human Nutrition
Nicole L. Glazer - University of Washington
Michael E. Goddard - University of Melbourne
Nancy L. Heard-Costa - Boston University
Volker Hoesel - Technical University of Munich
Jouke-Jan Hottenga - University of Amsterdam
Asa Johansson - Uppsala University
Toby Johnson - University of Lausanne
Shamika Ketkar - Washington University in St. Louis
Claudia Lamina - Helmholtz Zentrum München
Shengxu Li - MRC Epidemiology Unit
Miriam F. Moffatt - Imperial College London
Richard H. Myers - Boston University
Narisu Narisu - National Human Genome Research Institute
John R. B. Perry - University of Exeter
Marjolein J. Peters - Erasmus MC
Michael Preuss - University of Lübeck
Samuli Ripatti - Institute for Molecular Medicine Finland
Fernando Rivadeneira - Erasmus MC
Camilla Sandholt - Hagedorn Res Inst, Gentofte, Denmark
Laura J. Scott - University of Michigan–Ann Arbor
Nicholas J. Timpson - Avon
Jonathan P. Tyrer - University of Cambridge
Sophie van Wingerden - Erasmus MC
Richard M. Watanabe - University of Southern California
Charles C. White - Boston University
Fredrik Wiklund - Karolinska Institutet
Christina Barlassina - University of Milan
Daniel I. Chasman - Brigham and Women's Hospital
Matthew N. Cooper - University of Western Australia
John-Olov Jansson - University of Gothenburg
Robert W. Lawrence - University of Western Australia
Niina Pellikka - University of Helsinki
Inga Prokopenko - Oxford Centre for Diabetes, Endocrinology and Metabolism
Jianxin Shi - National Cancer Institute
Elisabeth Thiering - Helmholtz Zentrum München
Helene Alavere - University of Tartu
Maria T. S. Alibrandi - Vita-Salute San Raffaele University
Peter Almgren - Lund University
Alice M. Arnold - University of Washington
Thor Aspelund - Icelandic Heart Association
Larry D. Atwood - Boston University
Beverley Balkau - Centre de recherche en Epidémiologie et Santé des Populations
Anthony J. Balmforth - University of Leeds
Amanda J. Bennett - University of Oxford
Yoav Ben-Shlomo - University of Bristol
Richard N. Bergman - University of Southern California
Sven Bergmann - University of Lausanne
Heike Biebermann - Charité - Universitätsmedizin Berlin
Alexandra I. F. Blakemore - Imperial College London
Tanja Boes - University of Duisburg-Essen
Lori L. Bonnycastle - National Human Genome Research Institute
Stefan R. Bornstein - TU Dresden
Morris J. Brown - University of Cambridge
Thomas A. Buchanan - University of Southern California
MAGIC
Publication Details: Nature genetics, Vol.42(11), pp.937-U53
Publisher: Springer Nature
Number of pages: 14
Date published: 01/11/2010
Grant note: Danish Pharmaceutical Association FKZ 01GS0823 / German National Genome Research Net 'NGFNplus' National Cancer Institute; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI) QLG1-CT-2000-01643; QLG2-CT-2002-01254; LSHC-CT-2005; LSHG-CT-2006-018947; LSHG-CT-2004-518153; LSH-2006-037593; LSHM-CT-2007-037273; HEALTH- F2-2008-ENGAGE; HEALTH-F4-2007-201413; HEALTH-F4-2007-201550; 205419; 212111; 245536; SOC 9520140805F02; WLRT-2001-01254 / European Commission; European Union (EU); European Commission Joint Research Centre Healthway, Western Australia Ministry of Education (Finland) 97020; PG/02/128 / British Heart Foundation Municipal Health Care Center and Hospital in Jakobstad ALF/LUA Emil and Vera Cornell Foundation
Identifiers: 99928748402346
Academic Unit: School of Biosciences
Language: English
Resource Type: Journal article

Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index

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