Abstract
The zebrafish (Danio rerio) is widely used as a powerful model organism in biomedical and drug screening research1. With an exceptional capacity to assess multiple compounds per day, fish-based screenings have already been used to identify several drugs that reached preclinical and clinical trials2. Zebrafish have also emerged as an important species for probing mechanisms of brain function and dysfunction. These studies include modeling multiple central nervous system (CNS) diseases3, such as depression, anxiety, psychosis, attention deficit hyperactivity disorder, autism, neurodegenerative disorders and addiction. Collectively, these applications highlight the potential of zebrafish models for neurobehavioral research and high-throughput genetic and small neuroactive molecule screening.