Abstract
Human studies suggest that reducing dietary saturated fatty acids (SFAs) via replacing it with unsaturated fatty acids (UFAs) has a beneficial effect on fasting low-density lipoprotein cholesterol (LDL-C)(Reference Siri-Tarino, Sun and Hu1). However, significant variation in LDL-C concentration has been observed in response to change in dietary SFA intake(Reference Vafeiadou, Weech and Altowaijri2,Reference Jebb, Lovegrove and Griffin3) and there is considerable interest in potential determinants underlying the responsiveness of LDL-C to fat intake. Dietary fat composition affects body fat distribution with higher SFA intakes associated with abdominal obesity and greater cardiovascular disease (CVD) risk(Reference Rosqvist, Iggman and Kullberg4). However, it is not clear whether the variability in LDL-C response to dietary SFA is related to changes in body composition.