Genome-wide association study identifies 48 common genetic variants associated with handedness

Gabriel Cuellar-Partida; Joyce Y. Tung; Nicholas Eriksson; Eva Albrecht; Fazil Aliev; Ole A. Andreassen; Ines Barroso; Jacques S. Beckmann; Marco P. Boks; Dorret I. Boomsma; Heather A. Boyd; Monique M. B. Breteler; Harry Campbell; Daniel I. Chasman; Lynn F. Cherkas; Gail Davies; Eco J. C. de Geus; Ian J. Deary; Panos Deloukas; Danielle M. Dick; David L. Duffy; Johan G. Eriksson; Tonu Esko; Bjarke Feenstra; Frank Geller; Christian Gieger; Ina Giegling; Scott D. Gordon; Jiali Han; Thomas F. Hansen; Annette M. Hartmann; Caroline Hayward; Kauko Heikkila; Andrew A. Hicks; Joel N. Hirschhorn; Jouke-Jan Hottenga; Jennifer E. Huffman; Liang-Dar Hwang; M. Arfan Ikram; Jaakko Kaprio; John P. Kemp; Kay-Tee Khaw; Norman Klopp; Bettina Konte; Zoltan Kutalik; Jari Lahti; Xin Li; Ruth J. F. Loos; Michelle Luciano; Sigurdur H. Magnusson; Massimo Mangino; Pedro Marques-Vidal; Nicholas G. Martin; Wendy L. McArdle; Mark I. McCarthy; Carolina Medina-Gomez; Mads Melbye; Scott A. Melville; Andres Metspalu; Lili Milani; Vincent Mooser; Mari Nelis; Dale R. Nyholt; Kevin S. O'Connell; Roel A. Ophoff; Cameron Palmer; Aarno Palotie; Teemu Palviainen; Guillaume Pare; Lavinia Paternoster; Leena Peltonen; Brenda W. J. H. Penninx; Ozren Polasek; Peter P. Pramstaller; Inga Prokopenko; Katri Raikkonen; Samuli Ripatti; Fernando Rivadeneira; Igor Rudan; Dan Rujescu; Johannes H. Smit; George Davey Smith; Jordan W. Smoller; Nicole Soranzo; Tim D. Spector; Beate St Pourcain; John M. Starr; Hreinn Stefansson; Stacy Steinberg; Maris Teder-Laving; Gudmar Thorleifsson; Kari Stefansson; Nicholas J. Timpson; Andre G. Uitterlinden; Cornelia M. van Duijn; Frank J. A. van Rooij; Jaqueline M. Vink; Peter Vollenweider; Eero Vuoksimaa; Gerard Waeber; Nicholas J. Wareham; Nicole Warrington; Dawn Waterworth; Thomas Werge; H. -Erich Wichmann; Elisabeth Widen; Gonneke Willemsen; Alan F. Wright; Margaret J. Wright; Mousheng Xu; Jing Hua Zhao; Peter Kraft; David A. Hinds; Cecilia M. Lindgren; Reedik Magi; Benjamin M. Neale; David M. Evans; Sarah E. Medland

doi:10.1038/s41562-020-00956-y

Back

Genome-wide association study identifies 48 common genetic variants associated with handedness

Journal article

Peer reviewed

Genome-wide association study identifies 48 common genetic variants associated with handedness

Gabriel Cuellar-Partida, Joyce Y. Tung, Nicholas Eriksson, Eva Albrecht, Fazil Aliev, Ole A. Andreassen, Ines Barroso, Jacques S. Beckmann, Marco P. Boks, Dorret I. Boomsma, …

Nature human behaviour, Vol.5(1), pp.59-70

01/01/2021

DOI: https://doi.org/10.1038/s41562-020-00956-y

PMCID: 7116623

PMID: 32989287

Abstract

Life Sciences & Biomedicine

Multidisciplinary Sciences

Neurosciences

Neurosciences & Neurology

Psychology, Biological

Psychology, Experimental

Science & Technology

Science & Technology - Other Topics

Psychology

Social Sciences

Handedness has been extensively studied because of its relationship with language and the over-representation of left-handers in some neurodevelopmental disorders. Using data from the UK Biobank, 23andMe and the International Handedness Consortium, we conducted a genome-wide association meta-analysis of handedness (N = 1,766,671). We found 41 loci associated (P < 5 x 10(-8)) with left-handedness and 7 associated with ambidexterity. Tissue-enrichment analysis implicated the CNS in the aetiology of handedness. Pathways including regulation of microtubules and brain morphology were also highlighted. We found suggestive positive genetic correlations between left-handedness and neuropsychiatric traits, including schizophrenia and bipolar disorder. Furthermore, the genetic correlation between left-handedness and ambidexterity is low (r(G) = 0.26), which implies that these traits are largely influenced by different genetic mechanisms. Our findings suggest that handedness is highly polygenic and that the genetic variants that predispose to left-handedness may underlie part of the association with some psychiatric disorders. A genome-wide association study of 1.7 million individuals identified 41 genetic variants associated with left-handedness and 7 associated with ambidexterity. The genetic correlation between the traits was low, thereby implying different aetiologies.

Metrics

Details

Title: Genome-wide association study identifies 48 common genetic variants associated with handedness
Creators: Gabriel Cuellar-Partida - 23andMe
Joyce Y. Tung - 23andMe
Nicholas Eriksson - 23andMe
Eva Albrecht - Helmholtz Zentrum München
Fazil Aliev - Karabük University
Ole A. Andreassen - University of Oslo
Ines Barroso - Wellcome Sanger Institute
Jacques S. Beckmann - University Hospital of Lausanne
Marco P. Boks - University Medical Center Utrecht
Dorret I. Boomsma - Amsterdam University Medical Centers
Heather A. Boyd - Statens Serum Institut
Monique M. B. Breteler - German Center for Neurodegenerative Diseases
Harry Campbell - University of Edinburgh
Daniel I. Chasman - Brigham and Women's Hospital
Lynn F. Cherkas - King's College London
Gail Davies - University of Edinburgh
Eco J. C. de Geus - Amsterdam University Medical Centers
Ian J. Deary - University of Edinburgh
Panos Deloukas - Queen Mary University of London
Danielle M. Dick - Virginia Commonwealth University
David L. Duffy - QIMR Berghofer Medical Research Institute
Johan G. Eriksson - Singapore Institute for Clinical Sciences
Tonu Esko - Broad Institute
Bjarke Feenstra - Statens Serum Institut
Frank Geller - Statens Serum Institut
Christian Gieger - Helmholtz Zentrum München
Ina Giegling - Martin Luther University Halle-Wittenberg
Scott D. Gordon - QIMR Berghofer Medical Research Institute
Jiali Han - Indiana University – Purdue University Indianapolis
Thomas F. Hansen - Copenhagen University Hospital
Annette M. Hartmann - Martin Luther University Halle-Wittenberg
Caroline Hayward - MRC Institute of Genetics and Molecular Medicine
Kauko Heikkila - Institute for Molecular Medicine Finland
Andrew A. Hicks - Institute for Biomedicine
Joel N. Hirschhorn - Broad Institute
Jouke-Jan Hottenga - Amsterdam University Medical Centers
Jennifer E. Huffman - MRC Institute of Genetics and Molecular Medicine
Liang-Dar Hwang - University of Queensland
M. Arfan Ikram - Erasmus MC
Jaakko Kaprio - University of Helsinki
John P. Kemp - Medical Research Council
Kay-Tee Khaw - University of Cambridge
Norman Klopp - Medizinische Hochschule Hannover
Bettina Konte - Martin Luther University Halle-Wittenberg
Zoltan Kutalik - University of Lausanne
Jari Lahti - University of Turku
Xin Li - Indiana University – Purdue University Indianapolis
Ruth J. F. Loos - MRC Epidemiology Unit
Michelle Luciano - University of Edinburgh
Sigurdur H. Magnusson - deCODE Genet, Reykjavik, Iceland
Massimo Mangino - King's College London
Pedro Marques-Vidal - University of Lausanne
Nicholas G. Martin - QIMR Berghofer Medical Research Institute
Wendy L. McArdle - University of Bristol
Mark I. McCarthy - Wellcome Centre for Human Genetics
Carolina Medina-Gomez - Erasmus MC
Mads Melbye - Stanford University
Scott A. Melville - Institute for Biomedicine
Andres Metspalu - University of Tartu
Lili Milani - University of Tartu
Vincent Mooser - University of Lausanne
Mari Nelis - University of Tartu
Dale R. Nyholt - Queensland University of Technology
Kevin S. O'Connell - University of Oslo
Roel A. Ophoff - Neurobehavioral Research
Cameron Palmer - Columbia University
Aarno Palotie - Institute for Molecular Medicine Finland
Teemu Palviainen - Institute for Molecular Medicine Finland
Guillaume Pare - McMaster University
Lavinia Paternoster - MRC Epidemiology Unit
Leena Peltonen - University of Helsinki
Brenda W. J. H. Penninx - Amsterdam University Medical Centers
Ozren Polasek - University of Split
Peter P. Pramstaller - Institute for Biomedicine
Inga Prokopenko - University of Surrey
Katri Raikkonen - University of Helsinki
Samuli Ripatti - Institute for Molecular Medicine Finland
Fernando Rivadeneira - Erasmus MC
Igor Rudan - University of Edinburgh
Dan Rujescu - Martin Luther University Halle-Wittenberg
Johannes H. Smit - Amsterdam University Medical Centers
George Davey Smith - MRC Epidemiology Unit
Jordan W. Smoller - Massachusetts General Hospital
Nicole Soranzo - Wellcome Sanger Institute
Tim D. Spector - King's College London
Beate St Pourcain - MRC Epidemiology Unit
John M. Starr - University of Edinburgh
Hreinn Stefansson - deCODE Genetics
Stacy Steinberg - deCODE Genetics
Maris Teder-Laving - University of Tartu
Gudmar Thorleifsson - deCODE Genetics
Kari Stefansson - deCODE Genetics
Nicholas J. Timpson - University of Bristol
Andre G. Uitterlinden - Erasmus MC
Cornelia M. van Duijn - Erasmus MC
Frank J. A. van Rooij - Erasmus MC
Jaqueline M. Vink - Vrije Universiteit Amsterdam
Peter Vollenweider - University of Lausanne
Eero Vuoksimaa - University of Helsinki
Gerard Waeber - University of Lausanne
Nicholas J. Wareham - MRC Epidemiology Unit
Nicole Warrington - University of Queensland
Dawn Waterworth - GlaxoSmithKline
Thomas Werge - Lundbeck Foundation
H. -Erich Wichmann - Helmholtz Zentrum München
Elisabeth Widen - Institute for Molecular Medicine Finland
Gonneke Willemsen - Vrije Universiteit Amsterdam
Alan F. Wright - MRC Institute of Genetics and Molecular Medicine
Margaret J. Wright - ARC Centre of Excellence in Advanced Molecular Imaging
Mousheng Xu - Harvard University
Jing Hua Zhao - University of Cambridge
Peter Kraft - Harvard University
David A. Hinds - 23andMe
Cecilia M. Lindgren - Wellcome Centre for Human Genetics
Reedik Magi - University of Tartu
Benjamin M. Neale - Broad Institute
David M. Evans - MRC Epidemiology Unit
Sarah E. Medland - University of Queensland
Publication Details: Nature human behaviour, Vol.5(1), pp.59-70
Publisher: NATURE PORTFOLIO
Number of pages: 14
Date published: 01/01/2021
Grant note: NF-SI-0617-10090 / NIHR; National Institutes of Health Research (NIHR) Ministry for Health, Welfare and Sports SSVF 0646 / Danish Medical Research Council; UK Research & Innovation (UKRI); Medical Research Council UK (MRC) 014-93-015 / Research Institute for Diseases in the Elderly Finska Lakaresallskapet MC_UU_00007/10; MC_UU_12015/1; MC_UU_00011/1; MC_UU_00006/1; MC_UU_12013/4 / MRC; UK Research & Innovation (UKRI); Medical Research Council UK (MRC) Emil Aaltonen Foundation HEALTH-F4-2007-201413 / European Community 7th Framework Program (FP7/2007-2013): ENGAGE RO1 MH58799-03 / Developmental Study of Attention Problems in Young Twins (NIMH); United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Mental Health (NIMH) 201413 / ENGAGE -European Network for Genetic and Genomic Epidemiology, FP7-HEALTH-F4-2007 9602768 / European Community 7th Framework Program (FP7/2007-2013): ACTION Netherlands Organization for the Health Research and Development (ZonMw); Netherlands Organization for Health Research and Development Netherlands Organization for Scientific research (NWO); Netherlands Organization for Scientific Research (NWO) 480-15-001/674 / NWO; Netherlands Organization for Scientific Research (NWO) 175.010.2005.011; 911-03-012 / Netherlands Organisation of Scientific Research NWO Investments; Netherlands Organization for Scientific Research (NWO) Ministry of Education State of Bavaria Munich Center of Health Sciences (MC-Health), Ludwig-Maximilians-Universitat, as part of LMUinnovativ Egmont Foundation Widenlife APP1103623 / NHMRC Senior Research Fellowship; National Health and Medical Research Council (NHMRC) of Australia Oak Foundation NIHR Biomedical Research Centre, Oxford; National Institutes of Health Research (NIHR) NIMH U24 MH068457-06 / Rutgers University Cell and DNA Repository cooperative agreement Genetic Laboratory of the Department of Internal Medicine, Erasmus MC Folkhalsan Research Foundation Pharmacy Foundation Finnish Diabetes Research Society Signe and Ane Gyllenberg Foundation Helmholtz Zentrum Munchen-German Research Center for Environmental Health - German Federal Ministry of Education and Research (BMBF) PUT PRG687 / Estonian Research Council APP1104818 / Australian National Health and Medical Research Council Early Career Fellowship; National Health and Medical Research Council (NHMRC) of Australia MH081802 / Major depression: stage 1 genome-wide association in population-based samples 195/04 / Lundbeck Foundation; Lundbeckfonden Broad Institute 050-060-810 / Netherlands Genomics Initiative (NGI)/Netherlands Organisation for Scientific Research (NWO) Netherlands Consortium for Healthy Aging (NCHA); Netherlands Organization for Scientific Research (NWO) APP1137714 / National Health and Medical Research Council Senior Research Fellowship; National Health and Medical Research Council (NHMRC) of Australia Erasmus University, Rotterdam March of Dimes Birth Defects Foundation; March of Dimes 102215/2/13/2 / Wellcome Trust Augustinus Foundation NIH R01D0042157-01A1 / Collaborative Study of the Genetics of DZ twinning Municipality of Rotterdam Novo Nordisk Foundation; Novocure Limited PAH/6635 / KNAW Academy Professor Award 102215/2/13/2 / UK Medical Research Council; UK Research & Innovation (UKRI); Medical Research Council UK (MRC) European Commission (DG XII); European Commission; European Commission Joint Research Centre 5P50HD028138-27; R01 CA49449; P01 CA87969; UM1 CA186107; UM1 CA167552 / NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA NIDDK R01 DK092127-04 / Determinants of Adolescent Exercise Behavior Li Ka Shing Foundation NIMH 1RC2 MH089995 / Developmental Trajectories of Psychopathology 2014002959 / University of Queensland 090532; 106130; 098381; 203141; 212259; 095101; 200837; 099673/Z/12/Z; WT206194 / Wellcome; Wellcome Trust Ahokas Foundation Wellcome Trust Sanger Institute; Wellcome Trust PP1GI19935 / Institute of Genomics, University of Tartu WT-SSI/John Fell funds Amsterdam Public Health (APH) DE180100976 / Australia Research Council Discovery Early Career Researcher Award; Australian Research Council AA-12502; AA-00145; AA-09203; AA15416; K02AA018755 / National Institute of Alcohol Abuse and Alcoholism; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Alcohol Abuse & Alcoholism (NIAAA) Research Institute for Diseases in the Elderly (RIDE) Ministry of Education, Culture and Science; Ministry of Education, Culture, Sports, Science and Technology, Japan (MEXT) Danish National Research Foundation; Danmarks Grundforskningsfond 100499; 205585; 118555; 141054; 264146; 308248; 312073; 265240; 263278; 314639 / Academy of Finland; Research Council of Finland Juho Vainio Foundation Neuroscience Campus Amsterdam (NCA) 184.021.007; 184.033.111 / Biobanking and Biomolecular Resources Research Infrastructure (BBMRI-NL) Health Foundation Erasmus Medical Center, Rotterdam DE180100976 / Australian Research Council NIMH 1RC2MH089951-01 / Grand Opportunity grants Integration of Genomics and Transcriptomics University of Helsinki
Identifiers: 99817245502346
Academic Unit: School of Biosciences
Language: English
Resource Type: Journal article

Genome-wide association study identifies 48 common genetic variants associated with handedness

Abstract

Metrics

Details

Usage Policy