Transcriptomic response and immunological responses to chimpanzee adenovirus- and MVA viral-vectored vaccines for RSV in healthy adults

Catherine Green; J. McGinley; Charles J Sande; Stefania Capone; S. Makvandi-Nejad; A. Vitelli; Laura Silva-Reyes; Sagida Bibi; C. Otasowie; Dylan Sheerin; A. Thompson; Christina Dold; Paul Klenerman; E Barnes; Lucy Dorrell; Christine Rollier; Andrew J. Pollard; Daniel O'Connor

doi:10.1093/cei/uxad003

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Transcriptomic response and immunological responses to chimpanzee adenovirus- and MVA viral-vectored vaccines for RSV in healthy adults

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Transcriptomic response and immunological responses to chimpanzee adenovirus- and MVA viral-vectored vaccines for RSV in healthy adults

Catherine Green, J. McGinley, Charles J Sande, Stefania Capone, S. Makvandi-Nejad, A. Vitelli, Laura Silva-Reyes, Sagida Bibi, C. Otasowie, Dylan Sheerin, …

Clinical and experimental immunology, Vol.211(3), pp.269-279

24/03/2023

DOI: https://doi.org/10.1093/cei/uxad003

PMID: 36622786

Abstract

Life Sciences & Biomedicine

Science & Technology

Immunology

Cohorts of healthy younger adults (18-50yrs) and healthy older adults (60-75yrs) were immunized intramuscularly or intranasally with an adenovirus-vectored RSV vaccine (PanAd3-RSV) as a prime dose and boosted with PanAd3-RSV or a poxvirus-vectored vaccine (MVA-RSV) encoding the same insert. Whole blood gene expression was measured at baseline, 3- and 7-days post vaccination. Intramuscular prime vaccination with PanAd3-RSV induced differential expression of 643 genes (DEGs, FDR < 0.05). Intranasal prime vaccination with PanAd3-RSV did not induce any differentially expressed genes (DEGs) in blood samples at 3 days post vaccination. Intranasally primed participants showed greater numbers of DEGS on boosting than intramuscularly primed participants. The most highly enriched biological processes related to DEGs after both prime and boost vaccination were type-1 interferon related pathways, lymphocytic and humoral immune responses.

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Title: Transcriptomic response and immunological responses to chimpanzee adenovirus- and MVA viral-vectored vaccines for RSV in healthy adults
Creators: Catherine Green - Univ Oxford, Dept Paediat, Oxford Vaccine Grp, Oxford, Oxon, England
J. McGinley - Univ Oxford, Dept Paediat, Oxford Vaccine Grp, Oxford, Oxon, England
Charles J Sande - Univ Oxford, Dept Paediat, Oxford Vaccine Grp, Oxford, Oxon, England
Stefania Capone - Univ Oxford, NIHR Oxford Biomed Res Ctr, Oxford, Oxon, England
S. Makvandi-Nejad - Univ Oxford, Nuffield Dept Med, NDM Res Bldg, Oxford, Oxon, England
A. Vitelli - ReiThera Srl, Expt Vaccinol Dept, Rome, Italy
Laura Silva-Reyes - Univ Oxford, Dept Paediat, Oxford Vaccine Grp, Oxford, Oxon, England
Sagida Bibi - Univ Oxford, Dept Paediat, Oxford Vaccine Grp, Oxford, Oxon, England
C. Otasowie - Univ Oxford, Dept Paediat, Oxford Vaccine Grp, Oxford, Oxon, England
Dylan Sheerin - Univ Oxford, Dept Paediat, Oxford Vaccine Grp, Oxford, Oxon, England
A. Thompson - Univ Oxford, Dept Paediat, Oxford Vaccine Grp, Oxford, Oxon, England
Christina Dold - Univ Oxford, Dept Paediat, Oxford Vaccine Grp, Oxford, Oxon, England
Paul Klenerman
E Barnes - Univ Oxford, Nuffield Dept Med, Expt Med Div, Oxford, Oxon, England
Lucy Dorrell - Univ Oxford, Nuffield Dept Med, NDM Res Bldg, Oxford, Oxon, England
Christine Rollier
Andrew J. Pollard - Univ Oxford, NIHR Oxford Biomed Res Ctr, Oxford, Oxon, England
Daniel O'Connor - Univ Oxford, NIHR Oxford Biomed Res Ctr, Oxford, Oxon, England
Publication Details: Clinical and experimental immunology, Vol.211(3), pp.269-279
Publisher: Oxford Univ Press
Date published: 24/03/2023
Grant note: The RSV001 clinical trial was funded and sponsored by ReiThera S.r.l. (formerly Okairos S.r.l), which was acquired by GlaxoSmithKline Biologicals SA during the trial. Further funding and support was provided by the NIHR Oxford Biomedical Research and for Charles Sande and Paul Klenerman from the Wellcome Trust (WT 091663MA).
Identifiers: 99769366502346
Academic Unit: School of Biosciences
Language: English
Resource Type: Journal article

Transcriptomic response and immunological responses to chimpanzee adenovirus- and MVA viral-vectored vaccines for RSV in healthy adults

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