Genomic landscape of lung adenocarcinoma in East Asians

Jianbin Chen; Hechuan Yang; Audrey Su Min Teo; Lidyana Bte Amer; Faranak Ghazi Sherbaf; Chu Quan Tan; Jacob Josiah Santiago Alvarez; Bingxin Lu; Jia Qi Lim; Angela Takano; Rahul Nahar; Yin Yeng Lee; Cheryl Zi Jin Phua; Khi Pin Chua; Lisda Suteja; Pauline Jieqi Chen; Mei Mei Chang; Tina Puay Theng Koh; Boon-Hean Ong; Devanand Anantham; Anne Ann Ling Hsu; Apoorva Gogna; Chow Wei Too; Zaw Win Aung; Yi Fei Lee; Lanying Wang; Tony Kiat Hon Lim; Andreas Wilm; Poh Sum Choi; Poh Yong Ng; Chee Keong Toh; Wan-Teck Lim; Siming Ma; Bing Lim; Jin Liu; Wai Leong Tam; Anders Jacobsen Skanderup; Joe Poh Sheng Yeong; Eng-Huat Tan; Caretha L Creasy; Daniel Shao Weng Tan; Axel M Hillmer; Weiwei Zhai

doi:10.1038/s41588-019-0569-6

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Genomic landscape of lung adenocarcinoma in East Asians

Journal article

Peer reviewed

Genomic landscape of lung adenocarcinoma in East Asians

Jianbin Chen, Hechuan Yang, Audrey Su Min Teo, Lidyana Bte Amer, Faranak Ghazi Sherbaf, Chu Quan Tan, Jacob Josiah Santiago Alvarez, Bingxin Lu, Jia Qi Lim, Angela Takano, …

Nature genetics, Vol.52(2), pp.177-186

01/02/2020

DOI: https://doi.org/10.1038/s41588-019-0569-6

PMID: 32015526

Abstract

Adenocarcinoma of Lung - etiology

Adenocarcinoma of Lung - genetics

Adenocarcinoma of Lung - mortality

Adenocarcinoma of Lung - therapy

Aged

Asian Continental Ancestry Group - genetics

Cohort Studies

DNA Copy Number Variations

ErbB Receptors - genetics

Exome

Female

Gene Expression Profiling

Humans

Lung Neoplasms - etiology

Lung Neoplasms - genetics

Lung Neoplasms - mortality

Lung Neoplasms - therapy

Male

Middle Aged

Proto-Oncogene Proteins p21(ras) - genetics

Tumor Suppressor Protein p53 - genetics

Mutation

Singapore

Lung cancer is the world's leading cause of cancer death and shows strong ancestry disparities. By sequencing and assembling a large genomic and transcriptomic dataset of lung adenocarcinoma (LUAD) in individuals of East Asian ancestry (EAS; n = 305), we found that East Asian LUADs had more stable genomes characterized by fewer mutations and fewer copy number alterations than LUADs from individuals of European ancestry. This difference is much stronger in smokers as compared to nonsmokers. Transcriptomic clustering identified a new EAS-specific LUAD subgroup with a less complex genomic profile and upregulated immune-related genes, allowing the possibility of immunotherapy-based approaches. Integrative analysis across clinical and molecular features showed the importance of molecular phenotypes in patient prognostic stratification. EAS LUADs had better prediction accuracy than those of European ancestry, potentially due to their less complex genomic architecture. This study elucidated a comprehensive genomic landscape of EAS LUADs and highlighted important ancestry differences between the two cohorts.

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Title: Genomic landscape of lung adenocarcinoma in East Asians
Creators: Jianbin Chen - Agency for Science, Technology and Research
Hechuan Yang - Key Laboratory of Zoological Systematics and Evolution, Institute of Zoology, Chinese Academy of Sciences, Beijing, China
Audrey Su Min Teo - Agency for Science, Technology and Research
Lidyana Bte Amer - Agency for Science, Technology and Research
Faranak Ghazi Sherbaf - Agency for Science, Technology and Research
Chu Quan Tan - Genome Institute of Singapore
Jacob Josiah Santiago Alvarez - Agency for Science, Technology and Research
Bingxin Lu - Agency for Science, Technology and Research
Jia Qi Lim - Genome Institute of Singapore
Angela Takano - Singapore General Hospital
Rahul Nahar - Agency for Science, Technology and Research
Yin Yeng Lee - Genome Institute of Singapore
Cheryl Zi Jin Phua - Agency for Science, Technology and Research
Khi Pin Chua - Agency for Science, Technology and Research
Lisda Suteja - National Cancer Centre Singapore
Pauline Jieqi Chen - Agency for Science, Technology and Research
Mei Mei Chang - Genome Institute of Singapore
Tina Puay Theng Koh - National Cancer Centre Singapore
Boon-Hean Ong - National Heart Centre Singapore
Devanand Anantham - Singapore General Hospital
Anne Ann Ling Hsu - Singapore General Hospital
Apoorva Gogna - Singapore General Hospital
Chow Wei Too - Singapore General Hospital
Zaw Win Aung - National Cancer Centre Singapore
Yi Fei Lee - Nanyang Technological University
Lanying Wang - National Cancer Centre Singapore
Tony Kiat Hon Lim - Singapore General Hospital
Andreas Wilm - Agency for Science, Technology and Research
Poh Sum Choi - Agency for Science, Technology and Research
Poh Yong Ng - Genome Institute of Singapore
Chee Keong Toh - National Cancer Centre Singapore
Wan-Teck Lim - Agency for Science, Technology and Research
Siming Ma - Agency for Science, Technology and Research
Bing Lim - Agency for Science, Technology and Research
Jin Liu - Duke-NUS Medical School
Wai Leong Tam - Agency for Science, Technology and Research
Anders Jacobsen Skanderup - Agency for Science, Technology and Research
Joe Poh Sheng Yeong - Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (ASTAR), Singapore, Singapore
Eng-Huat Tan - National Cancer Centre Singapore
Caretha L Creasy - Oncology R&D, GlaxoSmithKline, Collegeville, PA, USA.
Daniel Shao Weng Tan - Agency for Science, Technology and Research
Axel M Hillmer - Agency for Science, Technology and Research
Weiwei Zhai - Agency for Science, Technology and Research
Publication Details: Nature genetics, Vol.52(2), pp.177-186
Date published: 01/02/2020
Identifiers: 99732260002346
Academic Unit: School of Biosciences
Language: English
Resource Type: Journal article

Genomic landscape of lung adenocarcinoma in East Asians

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