A Genome-Wide Association Study of Social and Non-Social Autistic-Like Traits in the General Population Using Pooled DNA, 500 K SNP Microarrays and Both Community and Diagnosed Autism Replication Samples

Angelica Ronald; Lee M. Butcher; Sophia Docherty; Oliver S. P. Davis; Leonard C. Schalkwyk; Ian W. Craig; Robert Plomin

doi:10.1007/s10519-009-9308-6

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A Genome-Wide Association Study of Social and Non-Social Autistic-Like Traits in the General Population Using Pooled DNA, 500 K SNP Microarrays and Both Community and Diagnosed Autism Replication Samples

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A Genome-Wide Association Study of Social and Non-Social Autistic-Like Traits in the General Population Using Pooled DNA, 500 K SNP Microarrays and Both Community and Diagnosed Autism Replication Samples

Angelica Ronald, Lee M. Butcher, Sophia Docherty, Oliver S. P. Davis, Leonard C. Schalkwyk, Ian W. Craig and Robert Plomin

Behavior genetics, Vol.40(1), pp.31-45

01/01/2010

DOI: https://doi.org/10.1007/s10519-009-9308-6

PMCID: PMC2797846

PMID: 20012890

Abstract

Behavioral Science and Psychology

Original Research

Clinical Psychology

Health Psychology

Psychology

Public Health

Two separate genome-wide association studies were conducted to identify single nucleotide polymorphisms (SNPs) associated with social and nonsocial autistic-like traits. We predicted that we would find SNPs associated with social and non-social autistic-like traits and that different SNPs would be associated with social and nonsocial. In Stage 1, each study screened for allele frequency differences in ~430,000 autosomal SNPs using pooled DNA on microarrays in high-scoring versus low-scoring boys from a general population sample ( N = ~400/group). In Stage 2, 22 and 20 SNPs in the social and non-social studies, respectively, were tested for QTL association by individually genotyping an independent community sample of 1,400 boys. One SNP (rs11894053) was nominally associated ( P < .05, uncorrected for multiple testing) with social autistic-like traits. When the sample was increased by adding females, 2 additional SNPs were nominally significant ( P < .05). These 3 SNPs, however, showed no significant association in transmission disequilibrium analyses of diagnosed ASD families.

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Title: A Genome-Wide Association Study of Social and Non-Social Autistic-Like Traits in the General Population Using Pooled DNA, 500 K SNP Microarrays and Both Community and Diagnosed Autism Replication Samples
Creators: Angelica Ronald - Birkbeck, University of London
Lee M. Butcher - Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, London, UK.
Sophia Docherty - Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, London, UK.
Oliver S. P. Davis - Bristol Medical School (PHS)
Leonard C. Schalkwyk - Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, London, UK.
Ian W. Craig - Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, London, UK.
Robert Plomin - Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, London, UK.
Publication Details: Behavior genetics, Vol.40(1), pp.31-45
Publisher: Springer US
Date published: 01/01/2010
Identifiers: 99731083202346
Academic Unit: School of Psychology
Language: English
Resource Type: Journal article

A Genome-Wide Association Study of Social and Non-Social Autistic-Like Traits in the General Population Using Pooled DNA, 500 K SNP Microarrays and Both Community and Diagnosed Autism Replication Samples

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