Multi-scale structural and mechanical characterisation in bioinspired polyurethane-based pancreatic cancer model

Jingyi Mo; Nathanael Leung; Priyanka Gupta; Bin Zhu; Hui Xing; Jiao Zhang; Eirini Velliou; Tan Sui

doi:10.1016/j.jmrt.2021.09.041

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Multi-scale structural and mechanical characterisation in bioinspired polyurethane-based pancreatic cancer model

Journal article

Open access

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Multi-scale structural and mechanical characterisation in bioinspired polyurethane-based pancreatic cancer model

Jingyi Mo, Nathanael Leung, Priyanka Gupta, Bin Zhu, Hui Xing, Jiao Zhang, Eirini Velliou and Tan Sui

Journal of materials research and technology, Vol.15, pp.2507-2517

11/2021

DOI: https://doi.org/10.1016/j.jmrt.2021.09.041

Abstract

Bioinspired polyurethane

in situ mechanical testing

Surface functionalisation

Synchrotron X-ray techniques

In this work, novel bioinspired polyurethane (PU) scaffolds were fabricated via freeze casting for PU-based Pancreatic Ductal Adenocarcinoma (PDAC) model. In order to reproduce the tumour micro-environment that facilitates cellular kinetics, the PU scaffolds were surface modified with extracellular matrix (ECM) proteins including collagen and fibronectin (Col and FN). Synchrotron-based small- and wide-angle X-ray scattering (SAXS/WAXS) techniques were applied to probe structural evolution during in situ mechanical testing. Strains at macroscopic, nano-, and lattice scales were obtained to investigate the effects of ECM proteins and pancreatic cell activities to PU scaffolds. Significant mechanical strengthening across length scales of PU scaffolds was observed in specimens surface modified by FN. A model of stiffness modulation via enhanced interlamellar recruitment is proposed to explain the multi-scale strengthening mechanisms. Understanding multi-scale deformation mechanisms of a series of PU scaffolds opens an opportunity in developing a novel pancreatic cancer model for studying cancer evolution and predicting outcomes of drug/treatments.

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Title: Multi-scale structural and mechanical characterisation in bioinspired polyurethane-based pancreatic cancer model
Creators: Jingyi Mo - University of Surrey, Department of Mechanical Engineering Sciences
Nathanael Leung - University of Surrey, Department of Mechanical Engineering Sciences
Priyanka Gupta - Bioprocess and Biochemical Engineering Group (BioProChem), Department of Chemical and Process Engineering, University of Surrey, Guildford, Surrey, GU2 7XH, UK
Bin Zhu - University of Surrey, Department of Mechanical Engineering Sciences
Hui Xing - School of Materials Science and Engineering, Shang Hai Jiao Tong University, Shang Hai, 200240, People’s Republic of China
Jiao Zhang - School of Materials Science and Engineering, Shang Hai Jiao Tong University, Shang Hai, 200240, People’s Republic of China
Eirini Velliou - University of Surrey, School of Chemistry and Chemical Engineering
Tan Sui - University of Surrey, Department of Mechanical Engineering Sciences
Publication Details: Journal of materials research and technology, Vol.15, pp.2507-2517
Publisher: Elsevier
Date published: 11/2021
Date accepted: 09/09/2021
Identifiers: 99607323702346
Academic Unit: Department of Mechanical Engineering Sciences; School of Chemistry and Chemical Engineering
Language: English
Resource Type: Journal article
SDG (Scopus 2023): SDG 3

Multi-scale structural and mechanical characterisation in bioinspired polyurethane-based pancreatic cancer model

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