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Coupling cell division to metabolic pathways through transcription
Book chapter   Peer reviewed

Coupling cell division to metabolic pathways through transcription

Petter Holland, Jens B Nielsen, Thierry D G A Mondeel and Matteo Barberis
Encyclopedia of Bioinformatics and Computational Biology: ABC of Bioinformatics, pp.74-93
Elsevier
21/08/2018

Abstract

Budding yeast Cell and Molecular Biology Cell- och molekylärbiologi Cellbiologi ChIP-exo ChIP-seq Chromatin immunoprecipitation (ChIP) Forkhead (Fkh) transcription factors Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy) Medicinsk bioteknologi (med inriktning mot cellbiologi (inklusive stamcellsbiologi), molekylärbiologi, mikrobiologi, biokemi eller biofarmaci) Transcriptional regulation Cell Biology Cell Cycle Data Analysis Gene Expression Metabolism
Cellular growth is ensured by alternation of DNA duplication and cell division cycles. This alternation is coordinated by the interplay between enzymatic activities, called kinases, and transcription factors, to keep the cell cycle timing. Here we investigate whether transcription factors may serve as hubs connecting multi-scale cellular networks. A variant of chromatin immunoprecipitation, called ChIP-exo, was performed to identify targets of Forkhead (Fkh) transcription factors across the budding yeast genome. Data analyses indicate that the Fkh-mediated transcriptional program may activate metabolic pathways and synchronize kinase activities to guarantee alternation of DNA duplication and cell division, thereby a timely cell’s cycling.

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