Abstract
Undertaking causal inference with observational data is incredibly useful across a wide range of tasks including the development of medical treatments, advertisements and marketing, and policy making. There are two significant challenges associated with undertaking causal inference using observational data: treatment assignment heterogeneity (i.e., differences between the treated and untreated groups), and an absence of counterfactual data (i.e., not knowing what would have happened if an individual who did get treatment, were instead to have not been treated). We address these two challenges by combining structured inference and targeted learning. In terms of structure, we factorize the joint distribution into risk, confounding, instrumental, and miscellaneous factors, and in terms of targeted learning, we apply a regularizer derived from the influence curve in order to reduce residual bias. An ablation study is undertaken, and an evaluation on benchmark datasets demonstrates that TVAE has competitive and state of the art performance across.