Long-term low-level ambient air pollution exposure and risk of lung cancer   A pooled analysis of 7 European cohorts

Ulla Arthur Hvidtfeldt; Gianluca Severi; Zorana Jovanovic Andersen; Richard Atkinson; Mariska Bauwelinck; Tom Bellander; Marie-Christine Boutron-Ruault; Jørgen Brandt; Bert Brunekreef; Giulia Cesaroni; Jie Chen; Hans Concin; Francesco Forastiere; Carla H van Gils; John Gulliver; Ole Hertel; Gerard Hoek; Barbara Hoffmann; Kees de Hoogh; Nicole Janssen; Karl-Heinz Jöckel; Jeanette Therming Jørgensen; Klea Katsouyanni; Matthias Ketzel; Jochem O Klompmaker; Norun Hjertager Krog; Alois Lang; Karin Leander; Shuo Liu; Petter L.S Ljungman; Patrik K.E Magnusson; Amar Jayant Mehta; Gabriele Nagel; Bente Oftedal; Göran Pershagen; Raphael Simon Peter; Annette Peters; Matteo Renzi; Debora Rizzuto; Sophia Rodopoulou; Evangelia Samoli; Per Everhard Schwarze; Torben Sigsgaard; Mette Kildevæld Simonsen; Massimo Stafoggia; Maciek Strak; Danielle Vienneau; Gudrun Weinmayr; Kathrin Wolf; Ole Raaschou-Nielsen; MATTHIAS  KETZEL; Daniela Fecht

doi:10.1016/j.envint.2020.106249

Back

Long-term low-level ambient air pollution exposure and risk of lung cancer A pooled analysis of 7 European cohorts

Journal article

Peer reviewed

Long-term low-level ambient air pollution exposure and risk of lung cancer A pooled analysis of 7 European cohorts

Ulla Arthur Hvidtfeldt, Gianluca Severi, Zorana Jovanovic Andersen, Richard Atkinson, Mariska Bauwelinck, Tom Bellander, Marie-Christine Boutron-Ruault, Jørgen Brandt, Bert Brunekreef, Giulia Cesaroni, …

Environment International, Vol.146, 106249

01/2021

DOI: https://doi.org/10.1016/j.envint.2020.106249

PMID: 33197787

Abstract

Dose response relationship

Particulate matter

Lung cancer incidence

Air Pollution

Background/aim Ambient air pollution has been associated with lung cancer, but the shape of the exposure-response function - especially at low exposure levels - is not well described. The aim of this study was to address the relationship between long-term low-level air pollution exposure and lung cancer incidence. Methods The “Effects of Low-level Air Pollution: a Study in Europe” (ELAPSE) collaboration pools seven cohorts from across Europe. We developed hybrid models combining air pollution monitoring, land use data, satellite observations, and dispersion model estimates for nitrogen dioxide (NO2), fine particulate matter (PM2.5), black carbon (BC), and ozone (O3) to assign exposure to cohort participants’ residential addresses in 100 m by 100 m grids. We applied stratified Cox proportional hazards models, adjusting for potential confounders (age, sex, calendar year, marital status, smoking, body mass index, employment status, and neighborhood-level socio-economic status). We fitted linear models, linear models in subsets, Shape-Constrained Health Impact Functions (SCHIF), and natural cubic spline models to assess the shape of the association between air pollution and lung cancer at concentrations below existing standards and guidelines. Results The analyses included 307,550 cohort participants. During a mean follow-up of 18.1 years, 3956 incident lung cancer cases occurred. Median (Q1, Q3) annual (2010) exposure levels of NO2, PM2.5, BC and O3 (warm season) were 24.2 µg/m3 (19.5, 29.7), 15.4 µg/m3 (12.8, 17.3), 1.6 10−5m−1 (1.3, 1.8), and 86.6 µg/m3 (78.5, 92.9), respectively. We observed a higher risk for lung cancer with higher exposure to PM2.5 (HR: 1.13, 95% CI: 1.05, 1.23 per 5 µg/m3). This association was robust to adjustment for other pollutants. The SCHIF, spline and subset analyses suggested a linear or supra-linear association with no evidence of a threshold. In subset analyses, risk estimates were clearly elevated for the subset of subjects with exposure below the EU limit value of 25 µg/m3. We did not observe associations between NO2, BC or O3 and lung cancer incidence. Conclusions Long-term ambient PM2.5 exposure is associated with lung cancer incidence even at concentrations below current EU limit values and possibly WHO Air Quality Guidelines.

Files and links (2)

pdf

EnvInt_2021_Hvidtfeldt_LungCancer_7EU_Cohorts955.82 kB

Restricted, access maybe granted on request

url

https://doi.org/10.1016/j.envint.2020.106249View

Published (Version of record) Open

Metrics

48 Record Views

76 Times Cited - Web of Science

See more details

Details

Title: Long-term low-level ambient air pollution exposure and risk of lung cancer A pooled analysis of 7 European cohorts
Creators: Ulla Arthur Hvidtfeldt - Danish Cancer Society Research Center, Strandboulevarden 49, 2100 Copenhagen, Denmark
Gianluca Severi - CESP, UMR 1018, Université Paris-Saclay, Inserm, Gustave Roussy, Villejuif, France
Zorana Jovanovic Andersen - Section of Environmental Health, Department of Public Health, University of Copenhagen, Øster Farimagsgade 5, 1014 Copenhagen, Denmark
Richard Atkinson - Population Health Research Institute and MRC-PHE Centre for Environment and Health, St George's, University of London, London, UK
Mariska Bauwelinck - Interface Demography – Department of Sociology, Vrije Universiteit Brussel, Pleinlaan 2, 1050 Brussels, Belgium
Tom Bellander - Institute of Environmental Medicine, Karolinska Institutet, Box 210, SE-171 77 Stockholm, Sweden
Marie-Christine Boutron-Ruault - CESP, UMR 1018, Université Paris-Saclay, Inserm, Gustave Roussy, Villejuif, France
Jørgen Brandt - Department of Environmental Science, Aarhus University, Frederiksborgvej 399, P.O.Box 358, 4000 Roskilde, Denmark
Bert Brunekreef - Institute of Risk Assessment Sciences (IRAS), University of Utrecht, P.O. Box 80177, NL 3508 TD Utrecht, the Netherlands
Giulia Cesaroni - Department of Epidemiology, Lazio Region Health Service/ASL Roma 1, 00147 Rome, Italy
Jie Chen - Institute of Risk Assessment Sciences (IRAS), University of Utrecht, P.O. Box 80177, NL 3508 TD Utrecht, the Netherlands
Hans Concin - Agency for Preventive and Social Medicine, Rheinstraße 61, 6900 Bregenz, Austria
Francesco Forastiere - Institute for Biomedical Research and Innovation (IRIB), National Research Council, 90146 Palermo, Italy
Carla H van Gils - Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, P.O. Box 85500, 3508 GA Utrecht, the Netherlands
John Gulliver - Centre for Environmental Health and Sustainability & School of Geography, Geology and the Environment, University of Leicester, Leicester, LE1 7RH, UK
Ole Hertel - Department of Environmental Science, Aarhus University, Frederiksborgvej 399, P.O.Box 358, 4000 Roskilde, Denmark
Gerard Hoek - Institute of Risk Assessment Sciences (IRAS), University of Utrecht, P.O. Box 80177, NL 3508 TD Utrecht, the Netherlands
Barbara Hoffmann - Institute of Occupational, Social and Environmental Medicine, Medical Faculty, Heinrich Heine University, Gurlittstraße 55, 40223 Dusseldorf, Germany
Kees de Hoogh - Swiss Tropical and Public Health Institute, Socinstrasse 57, 4051 Basel, Switzerland
Nicole Janssen - National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands
Karl-Heinz Jöckel - Institute for Medical Informatics, Biometry and Epidemiology, Medical Faculty, University of Duisburg-Essen, Essen, Germany
Jeanette Therming Jørgensen - Section of Environmental Health, Department of Public Health, University of Copenhagen, Øster Farimagsgade 5, 1014 Copenhagen, Denmark
Klea Katsouyanni - Dept. of Hygiene, Epidemiology and Medical Statistics, National and Kapodstrian University of Athens, Medical School 75, Mikras Asias Street 115 27 Athens, Greece
Matthias Ketzel - Department of Environmental Science, Aarhus University, Frederiksborgvej 399, P.O.Box 358, 4000 Roskilde, Denmark
Jochem O Klompmaker - Institute of Risk Assessment Sciences (IRAS), University of Utrecht, P.O. Box 80177, NL 3508 TD Utrecht, the Netherlands
Norun Hjertager Krog - Section of Air Pollution and Noise, Norwegian Institute of Public Health, P.O. Box 222, Skøyen, N-0213 Oslo, Norway
Alois Lang - Cancer Registry Vorarlberg, Agency for Preventive and Social Medicine, Rheinstraße 61, Bregenz 6900, Austria
Karin Leander - Institute of Environmental Medicine, Karolinska Institutet, Box 210, SE-171 77 Stockholm, Sweden
Shuo Liu - Section of Environmental Health, Department of Public Health, University of Copenhagen, Øster Farimagsgade 5, 1014 Copenhagen, Denmark
Petter L.S Ljungman - Institute of Environmental Medicine, Karolinska Institutet, Box 210, SE-171 77 Stockholm, Sweden
Patrik K.E Magnusson - Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, SE-171 77 Stockholm, Sweden
Amar Jayant Mehta - Statistics Denmark, Sejrøgade 11, 2100 Copenhagen, Denmark
Gabriele Nagel - Agency for Preventive and Social Medicine, Rheinstraße 61, 6900 Bregenz, Austria
Bente Oftedal - Section of Air Pollution and Noise, Norwegian Institute of Public Health, P.O. Box 222, Skøyen, N-0213 Oslo, Norway
Göran Pershagen - Institute of Environmental Medicine, Karolinska Institutet, Box 210, SE-171 77 Stockholm, Sweden
Raphael Simon Peter - Institute of Epidemiology and Medical Biometry, Ulm University, Helmholtzstr. 22, 89081 Ulm, Germany
Annette Peters - Institute of Epidemiology, Helmholtz Zentrum München, Ingolstädter Landstr. 1, 85764 Neuherberg, Germany
Matteo Renzi - Department of Epidemiology, Lazio Region Health Service/ASL Roma 1, 00147 Rome, Italy
Debora Rizzuto - Aging Research Center, Department of Neurobiology, Care Sciences, and Society, Karolinska Institutet and Stockholm University, Stockholm 17165, Sweden
Sophia Rodopoulou - Dept. of Hygiene, Epidemiology and Medical Statistics, National and Kapodstrian University of Athens, Medical School 75, Mikras Asias Street 115 27 Athens, Greece
Evangelia Samoli - Dept. of Hygiene, Epidemiology and Medical Statistics, National and Kapodstrian University of Athens, Medical School 75, Mikras Asias Street 115 27 Athens, Greece
Per Everhard Schwarze - Infection Control and Environmental Health, Norwegian Institute of Public Health, Oslo, Norway
Torben Sigsgaard - Department of Public Health, Environment Occupation and Health, Danish Ramazzini Centre, Aarhus University, Bartholins Allé 2, 8000 Aarhus, Denmark
Mette Kildevæld Simonsen - Diakonissestiftelsen and Parker Institute, Frederiksberg Hospital, Frederiksberg, Denmark
Massimo Stafoggia - Institute of Environmental Medicine, Karolinska Institutet, Box 210, SE-171 77 Stockholm, Sweden
Maciek Strak - Institute of Risk Assessment Sciences (IRAS), University of Utrecht, P.O. Box 80177, NL 3508 TD Utrecht, the Netherlands
Danielle Vienneau - Swiss Tropical and Public Health Institute, Socinstrasse 57, 4051 Basel, Switzerland
Gudrun Weinmayr - Institute of Epidemiology and Medical Biometry, Ulm University, Helmholtzstr. 22, 89081 Ulm, Germany
Kathrin Wolf - Institute of Epidemiology, Helmholtz Zentrum München, Ingolstädter Landstr. 1, 85764 Neuherberg, Germany
Ole Raaschou-Nielsen - Danish Cancer Society Research Center, Strandboulevarden 49, 2100 Copenhagen, Denmark
MATTHIAS KETZEL
Daniela Fecht - UK Small Area Health Statistics Unit, MRC Centre for Environment and Health, School of Public Health, Imperial College London, W2 1PG London, UK
Publication Details: Environment International, Vol.146, 106249
Publisher: Elsevier Ltd
Date published: 01/2021
Date accepted: 26/10/2020
Identifiers: 99528223202346
Academic Unit: School of Sustainability, Civil and Environmental Engineering
Language: English
Resource Type: Journal article
SDG (Scopus 2023): SDG 3| SDG 8

Long-term low-level ambient air pollution exposure and risk of lung cancer A pooled analysis of 7 European cohorts

Abstract

Files and links (2)

Metrics

Details

Usage Policy