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Differential effects of insulin detemir and neutral protamine Hagedorn (NPH) insulin on hepatic glucose production and peripheral glucose uptake during hypoglycaemia in type 1 diabetes.
Journal article

Differential effects of insulin detemir and neutral protamine Hagedorn (NPH) insulin on hepatic glucose production and peripheral glucose uptake during hypoglycaemia in type 1 diabetes.

F Smeeton, F Shojaee Moradie, RH Jones, L Westergaard, H Haahr, AM Umpleby and DL Russell-Jones
Diabetologia, Vol.52(11), pp.2317-2323
11/2009
DOI: https://doi.org/10.1007/s00125-009-1487-4

Abstract

Blood Glucose Blood Pressure Cross-Over Studies Diabetes Mellitus Type 1 Double-Blind Method Epinephrine Glucose Growth Hormone Heart Rate Humans Hypoglycemia Hypoglycemic Agents Infusions Intravenous Insulin Insulin Isophane Insulin Long-Acting Liver Patient Selection Reaction Time
We compared the symptoms of hypoglycaemia induced by insulin detemir (NN304) (B29Lys(epsilon-tetradecanoyl),desB30 human insulin) and equally effective doses of neutral protamine Hagedorn (NPH) insulin in relation to possible differential effects on hepatic glucose production and peripheral glucose uptake.

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