BRAF- and MEK-Targeted Small Molecule Inhibitors Exert Enhanced Antimelanoma Effects in Combination With Oncolytic Reovirus Through ER Stress

V Roulstone; M Pedersen; J Kyula; D Mansfield; AA Khan; G McEntee; M Wilkinson; E Karapanagiotou; M Coffey; R Marais; A Jebar; F Errington-Mais; A Melcher; R Vile; H Pandha; M McLaughlin; KJ Harrington

doi:10.1038/mt.2015.15

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BRAF- and MEK-Targeted Small Molecule Inhibitors Exert Enhanced Antimelanoma Effects in Combination With Oncolytic Reovirus Through ER Stress

Journal article

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BRAF- and MEK-Targeted Small Molecule Inhibitors Exert Enhanced Antimelanoma Effects in Combination With Oncolytic Reovirus Through ER Stress

V Roulstone, M Pedersen, J Kyula, D Mansfield, AA Khan, G McEntee, M Wilkinson, E Karapanagiotou, M Coffey, R Marais, …

MOLECULAR THERAPY, Vol.23(5), pp.931-942

01/05/2015

DOI: https://doi.org/10.1038/mt.2015.15

Abstract

Science & Technology

Life Sciences & Biomedicine

Biotechnology & Applied Microbiology

Genetics & Heredity

Medicine

Research & Experimental

Research & Experimental Medicine

ENDOPLASMIC-RETICULUM STRESS

HUMAN-MELANOMA CELLS

METASTATIC MELANOMA

IMPROVED SURVIVAL

MEDIATED APOPTOSIS

ADVANCED CANCER

PHASE-I

VEMURAFENIB

CHEMOTHERAPY

CYTOTOXICITY

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Title: BRAF- and MEK-Targeted Small Molecule Inhibitors Exert Enhanced Antimelanoma Effects in Combination With Oncolytic Reovirus Through ER Stress
Creators: V Roulstone
M Pedersen
J Kyula
D Mansfield
AA Khan
G McEntee
M Wilkinson
E Karapanagiotou
M Coffey
R Marais
A Jebar
F Errington-Mais
A Melcher
R Vile
H Pandha
M McLaughlin
KJ Harrington
Publication Details: MOLECULAR THERAPY, Vol.23(5), pp.931-942
Publisher: NATURE PUBLISHING GROUP
Date published: 01/05/2015
Date submitted: 17/05/2017
Identifiers: 99516574002346
Academic Unit: University of Surrey
Language: English
Resource Type: Journal article

BRAF- and MEK-Targeted Small Molecule Inhibitors Exert Enhanced Antimelanoma Effects in Combination With Oncolytic Reovirus Through ER Stress

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