Abstract
The roots of the endangered medicinal plant Croton megalocarpoides (Euphorbiaceae) collected in Kenya has been investigated. Twenty two compounds has been isolated. Among them twelve new ¬ent-clerodane (1-12) and a new abietane (13) diterpenoid alongside the known crotocorylifuran (4a), two known abietane and four known ent-trachylobane diterpenoids, and the triterpenoids, lupeol and acetyl aleurotolic acid. The structures of the compounds were determined using NMR, HRMS and ECD. The isolated compounds have been evaluated against a series of microorganisms (fungal and bacteria) and also against Plasmodium falciparum, however no activity was observed.