Abstract
Fault detection and diagnosis (FDD) is a critical approach to ensure safe and efficient operation of manufacturing and chemical processing plants. Multivariate statistical process monitoring (MSPM) has received considerable attention for FDD since it does not require a mechanistic process model. The diagnosis of the source or cause of the detected process fault in MSPM largely relies on contribution analysis, which is ineffective in identifying the joint contribution of multiple variables to the occurrence of fault. In this work, a missing variable analysis approach based on probabilistic principal component analysis is proposed for fault isolation. Furthermore, a branch and bound method is developed to handle the combinatorial nature of the problem involving finding the variables, which are most likely responsible for the occurrence of fault. The efficiency of the method proposed is shown through a case study on the Tennessee Eastman process.