Evaluation of the immunogenicity of prime-boost vaccination with the replication-deficient viral vectored COVID-19 vaccine candidate ChAdOx1 nCoV-19

Simon P. Graham; Rebecca K. McLean; Alexandra J. Spencer; Sandra Belij-Rammerstorfer; Daniel Wright; Marta Ulaszewska; Jane C. Edwards; Jack W. P. Hayes; Veronica Martini; Nazia Thakur; Carina Conceicao; Isabelle Dietrich; Holly Shelton; Ryan Waters; Anna Ludi; Ginette Wilsden; Clare Browning; Dagmara Bialy; Sushant Bhat; Phoebe Stevenson-Leggett; Philippa Hollinghurst; Ciaran Gilbride; David Pulido; Katy Moffat; Hannah Sharpe; Elizabeth Allen; Valerie Mioulet; Chris Chiu; Joseph Newman; Amin S. Asfor; Alison Burman; Sylvia Crossley; Jiandong Huo; Raymond J. Owens; Miles Carroll; John A. Hammond; Elma Tchilian; Dalan Bailey; Bryan Charleston; Sarah C. Gilbert; Tobias J. Tuthill; Teresa Lambe

doi:10.1038/s41541-020-00221-3

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Evaluation of the immunogenicity of prime-boost vaccination with the replication-deficient viral vectored COVID-19 vaccine candidate ChAdOx1 nCoV-19

Journal article

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Evaluation of the immunogenicity of prime-boost vaccination with the replication-deficient viral vectored COVID-19 vaccine candidate ChAdOx1 nCoV-19

Simon P. Graham, Rebecca K. McLean, Alexandra J. Spencer, Sandra Belij-Rammerstorfer, Daniel Wright, Marta Ulaszewska, Jane C. Edwards, Jack W. P. Hayes, Veronica Martini, Nazia Thakur, …

npj vaccines, Vol.5(1), pp.69-69

27/07/2020

DOI: https://doi.org/10.1038/s41541-020-00221-3

PMID: 32793398

Abstract

Immunology

Life Sciences & Biomedicine

Medicine, Research & Experimental

Research & Experimental Medicine

Science & Technology

Clinical development of the COVID-19 vaccine candidate ChAdOx1 nCoV-19, a replication-deficient simian adenoviral vector expressing the full-length SARS-CoV-2 spike (S) protein was initiated in April 2020 following non-human primate studies using a single immunisation. Here, we compared the immunogenicity of one or two doses of ChAdOx1 nCoV-19 in both mice and pigs. Whilst a single dose induced antigen-specific antibody and T cells responses, a booster immunisation enhanced antibody responses, particularly in pigs, with a significant increase in SARS-CoV-2 neutralising titres.

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Title: Evaluation of the immunogenicity of prime-boost vaccination with the replication-deficient viral vectored COVID-19 vaccine candidate ChAdOx1 nCoV-19
Creators: Simon P. Graham - The Pirbright Institute
Rebecca K. McLean - The Pirbright Institute
Alexandra J. Spencer - University of Oxford
Sandra Belij-Rammerstorfer - University of Oxford
Daniel Wright - University of Oxford
Marta Ulaszewska - University of Oxford
Jane C. Edwards - The Pirbright Institute
Jack W. P. Hayes - The Pirbright Institute
Veronica Martini - The Pirbright Institute
Nazia Thakur - The Pirbright Institute
Carina Conceicao - The Pirbright Institute
Isabelle Dietrich - The Pirbright Institute
Holly Shelton - The Pirbright Institute
Ryan Waters - The Pirbright Institute
Anna Ludi - The Pirbright Institute
Ginette Wilsden - The Pirbright Institute
Clare Browning - The Pirbright Institute
Dagmara Bialy - The Pirbright Institute
Sushant Bhat - The Pirbright Institute
Phoebe Stevenson-Leggett - The Pirbright Institute
Philippa Hollinghurst - The Pirbright Institute
Ciaran Gilbride - University of Oxford
David Pulido - University of Oxford
Katy Moffat - The Pirbright Institute
Hannah Sharpe - University of Oxford
Elizabeth Allen - University of Oxford
Valerie Mioulet - The Pirbright Institute
Chris Chiu - The Pirbright Institute
Joseph Newman - The Pirbright Institute
Amin S. Asfor - The Pirbright Institute
Alison Burman - The Pirbright Institute
Sylvia Crossley - The Pirbright Institute
Jiandong Huo - Rutherford Appleton Laboratory
Raymond J. Owens - University of Oxford
Miles Carroll - Public Health England
John A. Hammond - The Pirbright Institute
Elma Tchilian - The Pirbright Institute
Dalan Bailey - The Pirbright Institute
Bryan Charleston - The Pirbright Institute
Sarah C. Gilbert - University of Oxford
Tobias J. Tuthill - The Pirbright Institute
Teresa Lambe - University of Oxford
Publication Details: npj vaccines, Vol.5(1), pp.69-69
Publisher: Springer Nature
Number of pages: 6
Publication Date: 27/07/2020
Grant note: HHSN272201400008C / NIAID Centers of Excellence for Influenza Research and Surveillance (CEIRS) MC_PC_19055 / MRC; UK Research & Innovation (UKRI); Medical Research Council UK (MRC) EP/R013756/1 / UKRI Engineering and Physical Sciences Research Council (EPSRC); UK Research & Innovation (UKRI); Engineering & Physical Sciences Research Council (EPSRC) OPP1215550 / Bill and Melinda Gates Foundation; Bill & Melinda Gates Foundation EP/S025243/1; EP/R013756/1 / EPSRC; UK Research & Innovation (UKRI); Engineering & Physical Sciences Research Council (EPSRC) UK Department for Environment Food Rural Affairs; Department for Environment, Food & Rural Affairs (DEFRA) EP/S025243/1 / EPSRC; UK Research & Innovation (UKRI); Engineering & Physical Sciences Research Council (EPSRC) BBS/E/I/00007031; BBS/E/I/00007034; BBS/E/I/00007037; BBS/E/I/00007039 / UKRI Biotechnology and Biological Sciences Research Council (BBSRC); UK Research & Innovation (UKRI); Biotechnology and Biological Sciences Research Council (BBSRC) BBS/E/I/00007039; BBS/E/I/00007037; BBS/E/I/00007031; BBS/E/I/COV07000; BBS/E/I/00007038; BB/R019843/1; BBS/E/I/00007034; BB/S007911/1 / BBSRC; UK Research & Innovation (UKRI); Biotechnology and Biological Sciences Research Council (BBSRC)
Identifiers: 991175964202346; WOS:000552727000001
Academic Unit: School of Veterinary Medicine
Language: English
Resource Type: Journal article

Evaluation of the immunogenicity of prime-boost vaccination with the replication-deficient viral vectored COVID-19 vaccine candidate ChAdOx1 nCoV-19

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