A review of methods to synthesise 4'-substituted nucleosides

Mark Betson; Nigel Allanson; Philip Wainwright; Martha Elizabeth Betson

doi:10.1039/c4ob01449a

A review of methods to synthesise 4'-substituted nucleosides

Mark Betson, Nigel Allanson, Philip Wainwright Martha Elizabeth Betson

Organic & biomolecular chemistry, Vol.12(46), pp.9291-936

14/12/2014

: https://doi.org/10.1039/c4ob01449a

: 25302570

Alkylation

Chemistry Techniques, Synthetic

Deoxyribose - chemistry

Humans

Molecular Structure

Nucleosides - chemical synthesis

Ribose - chemistry

Stereoisomerism

Thioglycosides - chemistry

Modified nucleosides have received a great deal of attention from the scientific community, either for use as therapeutic agents, diagnostic tools, or as molecular probes. Perhaps the most difficult position of a nucleoside to modify is the 4'-position. Chemists have developed innovative methods to achieve this in a stereoselective manner to allow incorporation of a variety of functional groups. This review provides a summary of the most commonly used or recently published methods for ribose, deoxy-ribose, 4'-thioribose, and carbocyclics.

: A review of methods to synthesise 4'-substituted nucleosides
: Mark Betson - Castle Peak Hospital
Nigel Allanson - Castle Peak Hospital
Philip Wainwright - Castle Peak Hospital
Martha Elizabeth Betson - School of Veterinary Medicine
: Organic & biomolecular chemistry, Vol.12(46), pp.9291-936
: 14/12/2014
: 991111660802346; WOS:000344989700001
: School of Veterinary Medicine
: English
: Journal article