Expertise
Matteo's background integrates Industrial Biotechnology, Biochemistry, Molecular Biology and Computational Modeling. Thanks to this acquired interdisciplinarity, he has embarked in Systems Biology research by integrating experimentation and computation to decipher design principles underlying cellular organization. In his scientific research, Matteo employs modeling methodologies to predict systems properties, which he then tests experimentally.
Matteo has a profound interest in exploring the systems biology approaches to unravel design principles in the life sciences. His research aims, on the one hand, to bring together computation and experimentation to unravel molecular mechanisms, e.g. control of gene regulation, underlying switches responsible for temporal dynamics in cell cycle control and immune responses. On the other hand, he is developing multi-scale frameworks and tools that integrate by various modeling techniques layers of cellular regulation, with a particular emphasis on the interface between cell cycle and cell physiology.
Matteo's researches in Systems Biology involves: (i) integrating experimental and computational approaches to identify design principles underlying cellular organization, (ii) unraveling molecular switches in temporal dynamics, e.g. of cell cycle and of immune responses, (iii) developing multi-scale frameworks and tools that integrate layers of cellular regulation, and (iv) building cellular maps for network-based drug design, with a particular emphasis on cell physiology and disease.