Up-regulation of CYP1A/B in rat lung and liver, and human liver precision-cut slices by a series of polycyclic aromatic hydrocarbons; association with the Ah locus and importance of molecular size

DS Pushparajah; M Umachandran; T Nazir; KE Plant; N Plant; DFV Lewis; C Ioannides

doi:10.1016/j.tiv.2007.08.014

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Up-regulation of CYP1A/B in rat lung and liver, and human liver precision-cut slices by a series of polycyclic aromatic hydrocarbons; association with the Ah locus and importance of molecular size

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Up-regulation of CYP1A/B in rat lung and liver, and human liver precision-cut slices by a series of polycyclic aromatic hydrocarbons; association with the Ah locus and importance of molecular size

DS Pushparajah, M Umachandran, T Nazir, KE Plant, N Plant, DFV Lewis and C Ioannides

TOXICOLOGY IN VITRO, Vol.22(1), pp.128-145

01/02/2008

DOI: https://doi.org/10.1016/j.tiv.2007.08.014

Abstract

Science & Technology

Life Sciences & Biomedicine

Toxicology

TOXICOLOGY

precision-cut slices

polycyclic aromatic hydrocarbons

CYP1A

CYP1B

cytochromes p450

enzyme induction

DNA-ADDUCT FORMATION

CYTOCHROMES P450 1A1

METABOLIC-ACTIVATION

CARCINOGENIC POTENCY

DRUG-METABOLISM

GENE-EXPRESSION

MESSENGER-RNA

C57BL/6J MICE

HEPG2 CELLS

INDUCTION

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Title: Up-regulation of CYP1A/B in rat lung and liver, and human liver precision-cut slices by a series of polycyclic aromatic hydrocarbons; association with the Ah locus and importance of molecular size
Creators: DS Pushparajah
M Umachandran
T Nazir
KE Plant
N Plant
DFV Lewis
C Ioannides
Publication Details: TOXICOLOGY IN VITRO, Vol.22(1), pp.128-145
Publisher: PERGAMON-ELSEVIER SCIENCE LTD
Date published: 01/02/2008
Date submitted: 28/02/2012
Identifiers: 99513110702346
Academic Unit: School of Biosciences
Language: English
Resource Type: Journal article

Up-regulation of CYP1A/B in rat lung and liver, and human liver precision-cut slices by a series of polycyclic aromatic hydrocarbons; association with the Ah locus and importance of molecular size

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