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Undetected multidrug-resistant tuberculosis amplified by first-line therapy in mixed infection.
Journal article

Undetected multidrug-resistant tuberculosis amplified by first-line therapy in mixed infection.

SM Hingley-Wilson, R Casey, D Connell, S Bremang, JT Evans, PM Hawkey, GE Smith, A Jepson, S Philip, OM Kon, …
Emerg Infect Dis, Vol.19(7), pp.1138-1141
07/2013
DOI: https://doi.org/10.3201/1907.130313

Abstract

Mycobacterium tuberculosis TB antimicrobial resistance bacteria co-infection drug sensitive multidrug resistant treatment resistance tuberculosis and other mycobacteria Aged Antitubercular Agents Coinfection Culture Techniques Delayed Diagnosis Drug Resistance Multiple Bacterial Drug Therapy Combination Ethambutol Humans Isoniazid Male Minisatellite Repeats Molecular Diagnostic Techniques Multilocus Sequence Typing Mycobacterium tuberculosis Treatment Outcome Tuberculosis Multidrug-Resistant Tuberculosis Pulmonary
Infections with >1 Mycobacterium tuberculosis strain(s) are underrecognized. We show, in vitro and in vivo, how first-line treatment conferred a competitive growth advantage to amplify a multidrug-resistant M. tuberculosis strain in a patient with mixed infection. Diagnostic techniques that identify mixed tubercle bacilli populations are needed to curb the spread of multidrug resistance.
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http://www.ncbi.nlm.nih.gov/pubmed/23764343View
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