Therapeutic levels of FVIII following a single peripheral vein administration of rAAV vector encoding a novel human factor VIII variant

J McIntosh; PJ Lenting; C Rosales; D Lee; S Rabbanian; D Raj; N Patel; EGD Tuddenham; OD Christophe; JH McVey; S Waddington; AW Nienhuis; JT Gray; P Fagone; F Mingozzi; S-Z Zhou; KA High; M Cancio; CYC Ng; J Zhou; CL Morton; AM Davidoff; AC Nathwani

doi:10.1182/blood-2012-10-462200

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Therapeutic levels of FVIII following a single peripheral vein administration of rAAV vector encoding a novel human factor VIII variant

Journal article

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Therapeutic levels of FVIII following a single peripheral vein administration of rAAV vector encoding a novel human factor VIII variant

J McIntosh, PJ Lenting, C Rosales, D Lee, S Rabbanian, D Raj, N Patel, EGD Tuddenham, OD Christophe, JH McVey, …

BLOOD, Vol.121(17), pp.3335-3344

25/04/2013

DOI: https://doi.org/10.1182/blood-2012-10-462200

Abstract

Science & Technology

Life Sciences & Biomedicine

Hematology

HEMATOLOGY

ADENOASSOCIATED VIRAL VECTORS

RECOMBINANT FACTOR-VIII

MEDIATED GENE-TRANSFER

SEVERE HEMOPHILIA-A

COAGULATION-FACTOR VIII

FACTOR-IX EXPRESSION

EFFICIENT TRANSDUCTION

MONOCLONAL-ANTIBODIES

CAPSID PROTEINS

HEAVY-CHAIN

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Title: Therapeutic levels of FVIII following a single peripheral vein administration of rAAV vector encoding a novel human factor VIII variant
Creators: J McIntosh
PJ Lenting
C Rosales
D Lee
S Rabbanian
D Raj
N Patel
EGD Tuddenham
OD Christophe
JH McVey
S Waddington
AW Nienhuis
JT Gray
P Fagone
F Mingozzi
S-Z Zhou
KA High
M Cancio
CYC Ng
J Zhou
CL Morton
AM Davidoff
AC Nathwani
Publication Details: BLOOD, Vol.121(17), pp.3335-3344
Publisher: AMER SOC HEMATOLOGY
Date published: 25/04/2013
Date submitted: 17/05/2017
Identifiers: 99516917202346
Academic Unit: University of Surrey
Language: English
Resource Type: Journal article

Therapeutic levels of FVIII following a single peripheral vein administration of rAAV vector encoding a novel human factor VIII variant

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