The synthesis and development of 2,5-disubstituted tetrahydrofurans as potential scaffolds for diversity-oriented synthesis

Adrian P. Dobbs; Jonathan Dunn

doi:10.1016/j.tetlet.2012.02.100

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The synthesis and development of 2,5-disubstituted tetrahydrofurans as potential scaffolds for diversity-oriented synthesis

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The synthesis and development of 2,5-disubstituted tetrahydrofurans as potential scaffolds for diversity-oriented synthesis

Adrian P. Dobbs and Jonathan Dunn

Tetrahedron letters, Vol.53(19), pp.2392-2395

09/05/2012

DOI: https://doi.org/10.1016/j.tetlet.2012.02.100

Abstract

Chemistry

Chemistry, Organic

Physical Sciences

Science & Technology

The synthesis of 2,5-disubstituted tetrahydrofurans from donor silylmethylcyclopropanes (without bearing an acceptor function) is described. Their further elaboration via a wide range of synthetic transformations is presented to highlight the potential of this method and the resulting THFs as potential scaffolds for diversity-oriented synthesis. (C) 2012 Elsevier Ltd. All rights reserved.

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Title: The synthesis and development of 2,5-disubstituted tetrahydrofurans as potential scaffolds for diversity-oriented synthesis
Creators: Adrian P. Dobbs - Queen Mary University of London
Jonathan Dunn - Queen Mary University of London
Publication Details: Tetrahedron letters, Vol.53(19), pp.2392-2395
Publisher: Elsevier
Number of pages: 4
Publication Date: 09/05/2012
Grant note: EPSRC; UK Research & Innovation (UKRI); Engineering & Physical Sciences Research Council (EPSRC)
Identifiers: 99961142402346; WOS:000303232200006
Academic Unit: School of Chemistry and Chemical Engineering; Department of Chemistry
Language: English
Resource Type: Journal article

The synthesis and development of 2,5-disubstituted tetrahydrofurans as potential scaffolds for diversity-oriented synthesis

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