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The human cytochrome P450 sub-family: Transcriptional regulation, inter-individual variation and interaction networks
Journal article   Open access  Peer reviewed

The human cytochrome P450 sub-family: Transcriptional regulation, inter-individual variation and interaction networks

N Plant
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, Vol.1770(3), pp.478-488
01/03/2007
DOI: https://doi.org/10.1016/j.bbagen.2006.09.024

Abstract

Science & Technology Life Sciences & Biomedicine Biochemistry & Molecular Biology Biophysics BIOCHEMISTRY & MOLECULAR BIOLOGY BIOPHYSICS CYP3A gene expression PXR CAR nuclear receptor inter-individual variability drug-drug interactions PREGNANE-X-RECEPTOR ORPHAN NUCLEAR RECEPTOR DRUG-METABOLIZING-ENZYMES SITE-DIRECTED MUTAGENESIS CYP3A4 ACTIVE-SITE HUMAN LIVER HUMAN HEPATOCYTES PHARMACOKINETIC INTERACTIONS MIDAZOLAM CLEARANCE GENE-EXPRESSION
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