The RyR2-P2328S mutation downregulates Na(v)1.5 producing arrhythmic substrate in murine ventricles

F Ning; L Luo; S Ahmad; H Valli; K Jeevaratnam; T Wang; L Guzadhur; D Yang; JA Fraser; CL-H Huang; A Ma; SC Salvage

doi:10.1007/s00424-015-1750-0

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Journal article

The RyR2-P2328S mutation downregulates Na(v)1.5 producing arrhythmic substrate in murine ventricles

F Ning, L Luo, S Ahmad, H Valli, K Jeevaratnam, T Wang, L Guzadhur, D Yang, JA Fraser, CL-H Huang, …

PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, Vol.468(4), pp.655-665

01/04/2016

DOI: https://doi.org/10.1007/s00424-015-1750-0

Abstract

Science & Technology

Life Sciences & Biomedicine

Physiology

RyR2

CPVT

Nav1

5

Arrhythmogenicity

Conduction velocity

Ca2+ homeostasis

CARDIAC SODIUM-CHANNEL

ACTION-POTENTIAL ALTERNANS

RECEPTOR RYR2 GENE

ATRIAL-FIBRILLATION

INTRACELLULAR CALCIUM

CONDUCTION-VELOCITY

CYTOSOLIC CALCIUM

MOUSE MODEL

CLASS-I

TACHYCARDIA

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Title: The RyR2-P2328S mutation downregulates Na(v)1.5 producing arrhythmic substrate in murine ventricles
Creators: F Ning
L Luo
S Ahmad
H Valli
K Jeevaratnam
T Wang
L Guzadhur
D Yang
JA Fraser
CL-H Huang
A Ma
SC Salvage
Publication Details: PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, Vol.468(4), pp.655-665
Publisher: SPRINGER
Date published: 01/04/2016
Date submitted: 17/05/2017
Identifiers: 99511309202346
Academic Unit: University of Surrey
Language: English
Resource Type: Journal article

The RyR2-P2328S mutation downregulates Na(v)1.5 producing arrhythmic substrate in murine ventricles

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