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Synthesis of fluorous azodicarboxylates: towards cleaner Mitsunobu reactions
Journal article   Peer reviewed

Synthesis of fluorous azodicarboxylates: towards cleaner Mitsunobu reactions

Adrian P Dobbs and Caroline McGregor-Johnson
Tetrahedron letters, Vol.43(15), pp.2807-2810
08/04/2002

Abstract

The synthesis of a fluorous analogue of diethyl azodicarboxylate (DEAD) is described and preliminary results for its use in the Mitsunobu reaction given. Use of fluorous extraction methods have shown that chromatography is not necessary for reaction purification. Graphic

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