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Synthesis and structure-activity relationships of nitrobenzyl phosphoramide mustards as nitroreductase-activated prodrugs
Journal article

Synthesis and structure-activity relationships of nitrobenzyl phosphoramide mustards as nitroreductase-activated prodrugs

L Hu, X Wu, J Han, L Chen, SO Vass, P Browne, BS Hall, C Bot, V Gobalakrishnapillai, PF Searle, …
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, Vol.21(13), pp.3986-3991
01/07/2011
DOI: https://doi.org/10.1016/j.bmcl.2011.05.009

Abstract

Science & Technology Life Sciences & Biomedicine Physical Sciences Chemistry Medicinal Chemistry Organic Pharmacology & Pharmacy Chemistry CHEMISTRY MEDICINAL CHEMISTRY ORGANIC Nitroreductase Prodrug Phosphoramide mustard Antiproliferative Trypanosoma Leishmania ANTIBODY-DIRECTED ENZYME DRUG-DELIVERY THERAPY DESIGN STRATEGIES RESISTANCE HYPOXIA AGENTS
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