SFX-01 in hospitalised patients with community-acquired pneumonia during the COVID-19 pandemic: a double-blind, randomised, placebo-controlled trial

Merete B. Long; Hani Abo-Leyah; Yan Hui Giam; Thenmalar Vadiveloo; Rebecca C. Hull; Holly R. Keir; Thomas Pembridge; Daniela Alferes De Lima; Lilia Delgado; Sarah K. Inglis; Chloe Hughes; Amy Gilmour; Marek Gierlinski; Benjamin J.M. New; Graeme MacLennan; Albena T. Dinkova-Kostova; James D. Chalmers

doi:10.1183/23120541.00917-2023

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SFX-01 in hospitalised patients with community-acquired pneumonia during the COVID-19 pandemic: a double-blind, randomised, placebo-controlled trial

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SFX-01 in hospitalised patients with community-acquired pneumonia during the COVID-19 pandemic: a double-blind, randomised, placebo-controlled trial

Merete B. Long, Hani Abo-Leyah, Yan Hui Giam, Thenmalar Vadiveloo, Rebecca C. Hull, Holly R. Keir, Thomas Pembridge, Daniela Alferes De Lima, Lilia Delgado, Sarah K. Inglis, …

ERJ open research, Vol.10(2), p.917

01/03/2024

DOI: https://doi.org/10.1183/23120541.00917-2023

PMID: 38469377

Abstract

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Treatment with stabilised synthetic sulforaphane (SFX-01, 300 mg oral capsule) once daily for 14 days did not modulate key Nrf2 targets or improve clinical outcomes in patients hospitalised with CAP mainly due to SARS-CoV-2 infection https://bit.ly/4280Tvb

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Title: SFX-01 in hospitalised patients with community-acquired pneumonia during the COVID-19 pandemic: a double-blind, randomised, placebo-controlled trial
Creators: Merete B. Long - University of Dundee
Hani Abo-Leyah - University of Dundee
Yan Hui Giam - Ninewells Hospital
Thenmalar Vadiveloo - University of Aberdeen
Rebecca C. Hull - University of Sheffield
Holly R. Keir - Ninewells Hospital
Thomas Pembridge - University of Dundee
Daniela Alferes De Lima
Lilia Delgado - University of Dundee
Sarah K. Inglis - Ninewells Hospital
Chloe Hughes - Ninewells Hospital
Amy Gilmour - Ninewells Hospital
Marek Gierlinski - University of Dundee
Benjamin J.M. New - Ninewells Hospital
Graeme MacLennan - University of Aberdeen
Albena T. Dinkova-Kostova - Johns Hopkins Medicine
James D. Chalmers - University of Dundee
Publication Details: ERJ open research, Vol.10(2), p.917
Publisher: European Respiratory Society
Publication Date: 01/03/2024
Grant note: Evgen
Identifiers: 99961156202346; WOS:001193980300030
Academic Unit: School of Biosciences
Language: English
Resource Type: Journal article

SFX-01 in hospitalised patients with community-acquired pneumonia during the COVID-19 pandemic: a double-blind, randomised, placebo-controlled trial

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