Regulatory approval and a first-in-human phase I clinical trial of a monoclonal antibody produced in transgenic tobacco plants

JK-C Ma; J Drossard; D Lewis; F Altmann; J Boyle; P Christou; T Cole; P Dale; CJ van Dolleweerd; V Isitt; D Katinger; M Lobedan; H Mertens; MJ Paul; T Rademacher; M Sack; PAC Hundleby; G Stiegler; E Stoger; RM Twyman; B Vcelar; R Fischer

doi:10.1111/pbi.12416

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Regulatory approval and a first-in-human phase I clinical trial of a monoclonal antibody produced in transgenic tobacco plants

Journal article

Peer reviewed

Regulatory approval and a first-in-human phase I clinical trial of a monoclonal antibody produced in transgenic tobacco plants

JK-C Ma, J Drossard, D Lewis, F Altmann, J Boyle, P Christou, T Cole, P Dale, CJ van Dolleweerd, V Isitt, …

PLANT BIOTECHNOLOGY JOURNAL, Vol.13(8), pp.1106-1120

01/10/2015

DOI: https://doi.org/10.1111/pbi.12416

Abstract

Science & Technology

Life Sciences & Biomedicine

Biotechnology & Applied Microbiology

Plant Sciences

monoclonal antibody

transgenic plants

tobacco

phase I

human trial

good manufacturing practice

IMMUNODEFICIENCY-VIRUS TYPE-1

PHARMACEUTICAL PROTEINS

HIV-1 NEUTRALIZATION

2G12

TRANSMISSION

INFECTION

4E10

2F5

GLYCOSYLATION

MICROBICIDES

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Title: Regulatory approval and a first-in-human phase I clinical trial of a monoclonal antibody produced in transgenic tobacco plants
Creators: JK-C Ma
J Drossard
D Lewis
F Altmann
J Boyle
P Christou
T Cole
P Dale
CJ van Dolleweerd
V Isitt
D Katinger
M Lobedan
H Mertens
MJ Paul
T Rademacher
M Sack
PAC Hundleby
G Stiegler
E Stoger
RM Twyman
B Vcelar
R Fischer
Publication Details: PLANT BIOTECHNOLOGY JOURNAL, Vol.13(8), pp.1106-1120
Publisher: WILEY-BLACKWELL
Date published: 01/10/2015
Date submitted: 17/05/2017
Identifiers: 99510958702346
Academic Unit: University of Surrey
Language: English
Resource Type: Journal article

Regulatory approval and a first-in-human phase I clinical trial of a monoclonal antibody produced in transgenic tobacco plants

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