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Radiosensitization of glioblastoma cells using a histone deacetylase inhibitor (SAHA) comparing carbon ions with X-rays.
Journal article   Open access  Peer reviewed

Radiosensitization of glioblastoma cells using a histone deacetylase inhibitor (SAHA) comparing carbon ions with X-rays.

L Barazzuol, JC Jeynes, MJ Merchant, AC Wéra, MA Barry, KJ Kirkby and M Suzuki
Int J Radiat Biol, Vol.91(1), pp.90-98
01/2015
DOI: https://doi.org/10.3109/09553002.2014.946111

Abstract

DNA double-strand break repair High-LET chromatin decondensation clonogenic assay Carbon Cell Line Tumor DNA DNA Repair Glioblastoma Histone Deacetylase Inhibitors Histones Humans Hydroxamic Acids Radiation-Sensitizing Agents X-Rays
Prognosis for patients with glioblastoma (GBM) remains poor, and new treatments are needed. Here we used a combination of two novel treatment modalities: Carbon ions and a histone deacetylase inhibitor (HDACi). We compared these to conventional X-rays, measuring the increased effectiveness of carbon ions as well as radiosensitization using HDACi.
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TextSRIDA,  Open Access
url
http://dx.doi.org/10.3109/09553002.2014.946111View
Published (Version of record)
url
http://www.ncbi.nlm.nih.gov/pubmed/25040548View
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