Quantitative structure-activity relationships (QSARs) in inhibitors of various cytochromes P450: The importance of compound lipophilicity

DFV Lewis; BG Lake; M Dickins

doi:10.1080/14756360600952183

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Quantitative structure-activity relationships (QSARs) in inhibitors of various cytochromes P450: The importance of compound lipophilicity

Journal article

Peer reviewed

Quantitative structure-activity relationships (QSARs) in inhibitors of various cytochromes P450: The importance of compound lipophilicity

DFV Lewis, BG Lake and M Dickins

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, Vol.22(1), pp.1-6

01/02/2007

DOI: https://doi.org/10.1080/14756360600952183

Abstract

Science & Technology

Life Sciences & Biomedicine

Biochemistry & Molecular Biology

Chemistry

Medicinal

Pharmacology & Pharmacy

BIOCHEMISTRY & MOLECULAR BIOLOGY

CHEMISTRY

MEDICINAL

cytochrome P450

inhibitors

QSAR

lipophilicity

CYP2C5 CRYSTALLOGRAPHIC TEMPLATE

SUBSTRATE INTERACTIONS

METABOLISM

HOMOLOGY

BINDING

ENZYMES

CYP3A4

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Title: Quantitative structure-activity relationships (QSARs) in inhibitors of various cytochromes P450: The importance of compound lipophilicity
Creators: DFV Lewis
BG Lake
M Dickins
Publication Details: JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, Vol.22(1), pp.1-6
Publisher: TAYLOR & FRANCIS LTD
Date published: 01/02/2007
Date submitted: 17/05/2017
Identifiers: 99511070702346
Academic Unit: University of Surrey
Language: English
Resource Type: Journal article

Quantitative structure-activity relationships (QSARs) in inhibitors of various cytochromes P450: The importance of compound lipophilicity

Abstract

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