Quantitative structure-activity relationships (QSARs) for inhibitors and substrates of CYP2B enzymes: importance of compound lipophilicity in explanation of potency differences

DFV Lewis; Y Ito; BG Lake

doi:10.3109/14756360903514149

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Quantitative structure-activity relationships (QSARs) for inhibitors and substrates of CYP2B enzymes: importance of compound lipophilicity in explanation of potency differences

Journal article

Peer reviewed

Quantitative structure-activity relationships (QSARs) for inhibitors and substrates of CYP2B enzymes: importance of compound lipophilicity in explanation of potency differences

DFV Lewis, Y Ito and BG Lake

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, Vol.25(5), pp.679-684

01/10/2010

DOI: https://doi.org/10.3109/14756360903514149

Abstract

Science & Technology

Life Sciences & Biomedicine

Biochemistry & Molecular Biology

Chemistry

Medicinal

Pharmacology & Pharmacy

BIOCHEMISTRY & MOLECULAR BIOLOGY

CHEMISTRY

MEDICINAL

Cytochromes P450

QSARs

Lipophilicity

Enzyme Inhibition

DRUG-METABOLISM

PARTITION-COEFFICIENTS

CYTOCHROMES P450

3D DESCRIPTORS

IN-VITRO

BINDING

2D

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Title: Quantitative structure-activity relationships (QSARs) for inhibitors and substrates of CYP2B enzymes: importance of compound lipophilicity in explanation of potency differences
Creators: DFV Lewis
Y Ito
BG Lake
Publication Details: JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, Vol.25(5), pp.679-684
Publisher: TAYLOR & FRANCIS LTD
Date published: 01/10/2010
Date submitted: 17/05/2017
Identifiers: 99512186502346
Academic Unit: University of Surrey
Language: English
Resource Type: Journal article

Quantitative structure-activity relationships (QSARs) for inhibitors and substrates of CYP2B enzymes: importance of compound lipophilicity in explanation of potency differences

Abstract

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