Psychosocial impact of undergoing prostate cancer screening for men with BRCA1 or BRCA2 mutations

Elizabeth K. Bancroft; Sibel Saya; Elizabeth C. Page; Kathryn Myhill; Sarah Thomas; Jennifer Pope; Anthony Chamberlain; Rachel Hart; Wayne Glover; Jackie Cook; Derek J. Rosario; Brian T. Helfand; Christina Hutten Selkirk; Rosemarie Davidson; Mark Longmuir; Diana M. Eccles; Neus Gadea; Carole Brewer; Julian Barwell; Monica Salinas; Lynn Greenhalgh; Marc Tischkowitz; Alex Henderson; David Gareth Evans; Saundra S. Buys; Rosalind A. Eeles; Neil K. Aaronson; Rosalind Eeles; Elizabeth Bancroft; Elizabeth Page; Zsofia Kote-Jarai; Audrey Ardern-Jones; Chris Bangma; Elena Castro; David Dearnaley; Alison Falconer; Christopher Foster; Henrik Gronberg; Freddie C. Hamdy; Oskar Thor Johannsson; Vincent Khoo; Diana Eccles; Hans Lilja; Gareth Evans; Jorunn Eyfjord; Jan Lubinski; Lovise Maehle; Christos Mikropoulos; Alan Millner; Anita Mitra; Judith Offman; Clare Moynihan; Gad Rennert; Mohnish Suri; Alex Dias; Natalie Taylor; Lucia D'Mello; Jenny Pope; Paul James; Gillian Mitchell; Sue Shanley; Kate Richardson; Joanne McKinley; Lara Petelin; Morgan Murphy; Lyon Mascarenhas; Declan Murphy; Jimmy Lam; Louise Taylor; Cathy Miller; Alan Stapleton; Michael Chong; Graeme Suthers; Nicola Poplawski; Katherine Tucker; Lesley Andrews; Jessica Duffy; Richard Millard; Robyn Ward; Rachel Williams; Phillip Stricker; Judy Kirk; Michelle Bowman; Manish Patel; Marion Harris; Shona O'Connell; Clare Hunt; Courtney Smyth; Mark Frydenberg; Geoffrey Lindeman; Kylie Shackleton; Catherine Morton; Rachel Susman; Julie McGaughran; Melanie Boon; Nicholas Pachter; Sharron Townshend; Lyn Schofield; Cassandra Nicholls; Allan Spigelman; IMPACT Study Steering Comm; Christine June Jacobs

doi:10.1111/bju.14412

Back

Psychosocial impact of undergoing prostate cancer screening for men with BRCA1 or BRCA2 mutations

Journal article

Peer reviewed

Psychosocial impact of undergoing prostate cancer screening for men with BRCA1 or BRCA2 mutations

Elizabeth K. Bancroft, Sibel Saya, Elizabeth C. Page, Kathryn Myhill, Sarah Thomas, Jennifer Pope, Anthony Chamberlain, Rachel Hart, Wayne Glover, Jackie Cook, …

BJU international, Vol.123(2), pp.284-292

02/2019

DOI: https://doi.org/10.1111/bju.14412

PMID: 29802810

Abstract

Life Sciences & Biomedicine

Science & Technology

Urology & Nephrology

Objectives To report the baseline results of a longitudinal psychosocial study that forms part of the IMPACT study, a multi-national investigation of targeted prostate cancer (PCa) screening among men with a known pathogenic germline mutation in the BRCA1 or BRCA2 genes. Particpants and Methods Men enrolled in the IMPACT study were invited to complete a questionnaire at collaborating sites prior to each annual screening visit. The questionnaire included sociodemographic characteristics and the following measures: the Hospital Anxiety and Depression Scale (HADS), Impact of Event Scale (IES), 36-item short-form health survey (SF-36), Memorial Anxiety Scale for Prostate Cancer, Cancer Worry Scale-Revised, risk perception and knowledge. The results of the baseline questionnaire are presented. Results A total of 432 men completed questionnaires: 98 and 160 had mutations in BRCA1 and BRCA2 genes, respectively, and 174 were controls (familial mutation negative). Participants' perception of PCa risk was influenced by genetic status. Knowledge levels were high and unrelated to genetic status. Mean scores for the HADS and SF-36 were within reported general population norms and mean IES scores were within normal range. IES mean intrusion and avoidance scores were significantly higher in BRCA1/BRCA2 carriers than in controls and were higher in men with increased PCa risk perception. At the multivariate level, risk perception contributed more significantly to variance in IES scores than genetic status. Conclusion This is the first study to report the psychosocial profile of men with BRCA1/BRCA2 mutations undergoing PCa screening. No clinically concerning levels of general or cancer-specific distress or poor quality of life were detected in the cohort as a whole. A small subset of participants reported higher levels of distress, suggesting the need for healthcare professionals offering PCa screening to identify these risk factors and offer additional information and support to men seeking PCa screening.

Files and links (1)

url

https://doi.org/10.1111/bju.14412View

Published (Version of record) Open

Metrics

1 Record Views

See more details

Details

Title: Psychosocial impact of undergoing prostate cancer screening for men with BRCA1 or BRCA2 mutations
Creators: Elizabeth K. Bancroft - Institute of Cancer Research
Sibel Saya - Institute of Cancer Research
Elizabeth C. Page - Institute of Cancer Research
Kathryn Myhill - Royal Marsden NHS Foundation Trust
Sarah Thomas - Royal Marsden NHS Foundation Trust
Jennifer Pope - Institute of Cancer Research
Anthony Chamberlain - Royal Marsden NHS Foundation Trust
Rachel Hart - Birmingham Women's Hospital
Wayne Glover - Birmingham Women's Hospital
Jackie Cook - Sheffield Children's Hospital
Derek J. Rosario - Royal Hallamshire Hospital
Brian T. Helfand - NorthShore University HealthSystem
Christina Hutten Selkirk - NorthShore Univ HealthSyst, John & Carol Walter Ctr Urol Hlth, Evanston, IL USA
Rosemarie Davidson - Queen Elizabeth University Hospital
Mark Longmuir - Queen Elizabeth University Hospital
Diana M. Eccles - Princess Anne Hosp, Wessex Clin Genet Serv, Southampton, Hants, England
Neus Gadea - Vall d'Hebron Hospital Universitari
Carole Brewer - Royal Devon and Exeter Hospital
Julian Barwell - University Hospitals of Leicester NHS Trust
Monica Salinas - Institut Català d'Oncologia
Lynn Greenhalgh - Liverpool Women's Hospital
Marc Tischkowitz - University of Cambridge
Alex Henderson - Newcastle upon Tyne Hospital
David Gareth Evans - University of Manchester
Saundra S. Buys - Huntsman Cancer Institute
Rosalind A. Eeles - Princess Anne Hospital
Neil K. Aaronson - The Netherlands Cancer Institute
Rosalind Eeles - Princess Anne Hospital
Elizabeth Bancroft - Institute of Cancer Research
Elizabeth Page - Institute of Cancer Research
Zsofia Kote-Jarai - Inst Canc Res, 123 Old Brompton Rd, London SW7 3RP, England
Audrey Ardern-Jones - Royal Marsden NHS Fdn Trust, London, England
Chris Bangma - College Station Medical Center
Elena Castro - CNIO, Madrid, Spain
David Dearnaley - Inst Canc Res, 123 Old Brompton Rd, London SW7 3RP, England
Alison Falconer - Imperial Coll Healthcare NHS Trust, London, England
Christopher Foster - HCA Pathol Labs, London, England
Henrik Gronberg - Univ Hosp, Umea, Sweden
Freddie C. Hamdy - University of Oxford
Oskar Thor Johannsson - Landspitali Natl Univ Hosp Iceland, Reykjavik, Iceland
Vincent Khoo - Royal Marsden NHS Fdn Trust, London, England
Diana Eccles - Wessex Clin Genet Serv, Southampton, Hants, England
Hans Lilja - University of Oxford
Gareth Evans - St Marys Hosp, Manchester, Lancs, England
Jorunn Eyfjord - University of Iceland
Jan Lubinski - Int Hereditary Canc Ctr, Szczecin, Poland
Lovise Maehle - Norwegian Radium Hosp, Oslo, Norway
Christos Mikropoulos - Inst Canc Res, 123 Old Brompton Rd, London SW7 3RP, England
Alan Millner - Royal Marsden NHS Fdn Trust, London, England
Anita Mitra - Univ Coll London Hosp, London, England
Judith Offman - Kings Coll London, London, England
Clare Moynihan - Royal Marsden NHS Fdn Trust, London, England
Gad Rennert - Carmel
Mohnish Suri - Nottingham City Hosp, Nottingham, England
Alex Dias - Inst Canc Res, Coordinating Ctr, London, England
Natalie Taylor - Inst Canc Res, Coordinating Ctr, London, England
Lucia D'Mello - Inst Canc Res, Coordinating Ctr, London, England
Jenny Pope - Inst Canc Res, Coordinating Ctr, London, England
Paul James - Parkville Familial Canc Ctr, Peter MacCallum Canc Ctr, East Melbourne, Vic, Australia
Gillian Mitchell - Parkville Familial Canc Ctr, Peter MacCallum Canc Ctr, East Melbourne, Vic, Australia
Sue Shanley - Parkville Familial Canc Ctr, Peter MacCallum Canc Ctr, East Melbourne, Vic, Australia
Kate Richardson - Parkville Familial Canc Ctr, Peter MacCallum Canc Ctr, East Melbourne, Vic, Australia
Joanne McKinley - Parkville Familial Canc Ctr, Peter MacCallum Canc Ctr, East Melbourne, Vic, Australia
Lara Petelin - Parkville Familial Canc Ctr, Peter MacCallum Canc Ctr, East Melbourne, Vic, Australia
Morgan Murphy - Parkville Familial Canc Ctr, Peter MacCallum Canc Ctr, East Melbourne, Vic, Australia
Lyon Mascarenhas - Parkville Familial Canc Ctr, Peter MacCallum Canc Ctr, East Melbourne, Vic, Australia
Declan Murphy - Peter MacCallum Canc Ctr, Dept Urol, East Melbourne, Vic, Australia
Jimmy Lam - Repatriat Gen Hosp, Dept Urol, Daw Pk, SA, Australia
Louise Taylor - Repatriat Gen Hosp, Dept Urol, Daw Pk, SA, Australia
Cathy Miller - Repatriat Gen Hosp, Dept Urol, Daw Pk, SA, Australia
Alan Stapleton - Repatriat Gen Hosp, Dept Urol, Daw Pk, SA, Australia
Michael Chong - Repatriat Gen Hosp, Dept Urol, Daw Pk, SA, Australia
Graeme Suthers - SA Pathol Womens & Childrens Hosp, SA Clin Genet Serv, Adelaide, SA, Australia
Nicola Poplawski - SA Pathol Womens & Childrens Hosp, SA Clin Genet Serv, Adelaide, SA, Australia
Katherine Tucker - Prince Wales Hosp, Hereditary Canc Clin, Randwick, NSW, Australia
Lesley Andrews - Prince Wales Hosp, Hereditary Canc Clin, Randwick, NSW, Australia
Jessica Duffy - Prince Wales Hosp, Hereditary Canc Clin, Randwick, NSW, Australia
Richard Millard - Prince Wales Hosp, Dept Urol, Randwick, NSW, Australia
Robyn Ward - Supreme Council Of Health
Rachel Williams - Supreme Council Of Health
Phillip Stricker - St Vincents Clin, Sydney, NSW, Australia
Judy Kirk - Westmead Hosp, Familial Canc Serv, Wentworthville, NSW, Australia
Michelle Bowman - Westmead Hosp, Familial Canc Serv, Wentworthville, NSW, Australia
Manish Patel - Westmead Hosp, Wentworthville, NSW, Australia
Marion Harris - Monash Hlth, Familial Canc Ctr, Clayton, Vic, Australia
Shona O'Connell - Monash Hlth, Familial Canc Ctr, Clayton, Vic, Australia
Clare Hunt - Monash Hlth, Familial Canc Ctr, Clayton, Vic, Australia
Courtney Smyth - Monash Hlth, Familial Canc Ctr, Clayton, Vic, Australia
Mark Frydenberg - College Station Medical Center
Geoffrey Lindeman - Royal Melbourne Hosp, Parkville Familial Canc Ctr, Grattan St, Parkville, Vic, Australia
Kylie Shackleton - Royal Melbourne Hosp, Parkville Familial Canc Ctr, Grattan St, Parkville, Vic, Australia
Catherine Morton - Royal Melbourne Hosp, Parkville Familial Canc Ctr, Grattan St, Parkville, Vic, Australia
Rachel Susman - Royal Brisbane & Womens Hosp, Genet Hlth Queensland, Herston, Qld, Australia
Julie McGaughran - Royal Brisbane & Womens Hosp, Genet Hlth Queensland, Herston, Qld, Australia
Melanie Boon - Royal Brisbane & Womens Hosp, Genet Hlth Queensland, Herston, Qld, Australia
Nicholas Pachter - Mécanique et Engrenage Moderne
Sharron Townshend - Mécanique et Engrenage Moderne
Lyn Schofield - Mécanique et Engrenage Moderne
Cassandra Nicholls - Mécanique et Engrenage Moderne
Allan Spigelman - Hunter Family Canc Serv, NSW Allan Spigelman, Waratah, NSW, Australia
IMPACT Study Steering Comm
Christine June Jacobs - School of Health Sciences
Publication Details: BJU international, Vol.123(2), pp.284-292
Publisher: Wiley
Number of pages: 9
Date published: 02/2019
Grant note: National Institute for Health Research (NIHR); National Institutes of Health Research (NIHR) Ronald and Rita McAulay Foundation Institute of Cancer Research C5047/A21332; C5047/A13232; C5047/A17528 / Cancer Research UK NF-SI-0611-10106 / National Institute for Health Research; National Institutes of Health Research (NIHR)
Identifiers: 99928604102346
Academic Unit: School of Health Sciences
Language: English
Resource Type: Journal article

Psychosocial impact of undergoing prostate cancer screening for men with BRCA1 or BRCA2 mutations

Abstract

Files and links (1)

Metrics

Details

Usage Policy