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Prospective technical validation and assessment of intra-tumour heterogeneity of a low density array hypoxia gene profile in head and neck squamous cell carcinoma.
Journal article   Peer reviewed

Prospective technical validation and assessment of intra-tumour heterogeneity of a low density array hypoxia gene profile in head and neck squamous cell carcinoma.

GN Betts, A Eustace, S Patiar, HR Valentine, J Irlam, A Ramachandran, A Merve, JJ Homer, C Möller-Levet, FM Buffa, …
Eur J Cancer, Vol.49(1), pp.156-165
01/2013
DOI: https://doi.org/10.1016/j.ejca.2012.07.028

Abstract

Adult Aged Aged 80 and over Carcinoma Squamous Cell Cell Hypoxia Female Gene Expression Profiling Head and Neck Neoplasms Humans Immunohistochemistry Male Middle Aged Neoplasm Staging Real-Time Polymerase Chain Reaction Reproducibility of Results Reverse Transcriptase Polymerase Chain Reaction Sensitivity and Specificity Transcriptome
Tumour hypoxia is associated with a poor prognosis in head and neck squamous cell carcinoma (HNSCC), however there is no accepted method for assessing hypoxia clinically. We aimed to conduct a technical validation of a hypoxia gene expression signature using the TaqMan Low Density Array (TLDA) platform to investigate if this approach reliably identified hypoxic tumours.
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