Procalcitonin Is Not a Reliable Biomarker of Bacterial Coinfection in People With Coronavirus Disease 2019 Undergoing Microbiological Investigation at the Time of Hospital Admission

Katharine A. Relph; Clark D. Russell; Cameron J. Fairfield; Lance Turtle; Thushan de Silva; Matthew K. Siggins; Thomas M. Drake; Ryan S. Thwaites; Simon Abrams; Shona C. Moore; Hayley E. Hardwick; Wilna Oosthuyzen; Ewen M. Harrison; Annemarie B. Docherty; Peter J. M. Openshaw; J. Kenneth Baillie; Malcolm G. Semple; Antonia Ho; Int Severe Acute Resp Emerging Inf

doi:10.1093/ofid/ofac179

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Procalcitonin Is Not a Reliable Biomarker of Bacterial Coinfection in People With Coronavirus Disease 2019 Undergoing Microbiological Investigation at the Time of Hospital Admission

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Procalcitonin Is Not a Reliable Biomarker of Bacterial Coinfection in People With Coronavirus Disease 2019 Undergoing Microbiological Investigation at the Time of Hospital Admission

Katharine A. Relph, Clark D. Russell, Cameron J. Fairfield, Lance Turtle, Thushan de Silva, Matthew K. Siggins, Thomas M. Drake, Ryan S. Thwaites, Simon Abrams, Shona C. Moore, …

Open forum infectious diseases, Vol.9(5), p.ofac179

01/05/2022

DOI: https://doi.org/10.1093/ofid/ofac179

PMID: 35531376

Abstract

Immunology

Infectious Diseases

Life Sciences & Biomedicine

Microbiology

Science & Technology

Admission procalcitonin measurements and microbiology results were available for 1040 hospitalized adults with coronavirus disease 2019 (from 48 902 included in the International Severe Acute Respiratory and Emerging Infections Consortium World Health Organization Clinical Characterisation Protocol UK study). Although procalcitonin was higher in bacterial coinfection, this was neither clinically significant (median [IQR], 0.33 [0.11-1.70] ng/mL vs 0.24 [0.10-0.90] ng/mL) nor diagnostically useful (area under the receiver operating characteristic curve, 0.56 [95% confidence interval, .51-.60]).

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Title: Procalcitonin Is Not a Reliable Biomarker of Bacterial Coinfection in People With Coronavirus Disease 2019 Undergoing Microbiological Investigation at the Time of Hospital Admission
Creators: Katharine A. Relph - University of Edinburgh
Clark D. Russell - Centre for Inflammation Research
Cameron J. Fairfield - University of Edinburgh
Lance Turtle - Health Protection Research Unit in Emerging and Zoonotic Infections at University of Liverpool
Thushan de Silva - University of Sheffield
Matthew K. Siggins - Imperial College London
Thomas M. Drake - University of Edinburgh
Ryan S. Thwaites - Imperial College London
Simon Abrams - University of Liverpool
Shona C. Moore - Health Protection Research Unit in Emerging and Zoonotic Infections at University of Liverpool
Hayley E. Hardwick - Health Protection Research Unit in Emerging and Zoonotic Infections at University of Liverpool
Wilna Oosthuyzen - University of Edinburgh
Ewen M. Harrison - University of Edinburgh
Annemarie B. Docherty - University of Edinburgh
Peter J. M. Openshaw - Lung Institute
J. Kenneth Baillie - University of Edinburgh
Malcolm G. Semple - Health Protection Research Unit in Emerging and Zoonotic Infections at University of Liverpool
Antonia Ho - MRC University of Glasgow Centre for Virus Research
Int Severe Acute Resp Emerging Inf
Publication Details: Open forum infectious diseases, Vol.9(5), p.ofac179
Publisher: Oxford Univ Press
Number of pages: 6
Publication Date: 01/05/2022
Grant note: 215091/Z/18/Z / Wellcome Trust C18616/A25153 / Liverpool Experimental Cancer Medicine Centre NIHR Health Protection Research Unit (HPRU) in Emerging and Zoonotic Infections at University of Liverpool 205228/Z/16/Z / Wellcome Trust fellowship; Wellcome Trust MC_PC_19026 / MRC; UK Research & Innovation (UKRI); Medical Research Council UK (MRC) MC_PC_19059 / Medical Research Council; UK Research & Innovation (UKRI); Medical Research Council UK (MRC) MR/S032304/1 / FLF; UK Research & Innovation (UKRI) 200927 / Public Health England (PHE) 215091/Z/18/Z / Department for International Development CO-CIN-01 / National Institute for Health Research (NIHR); National Institutes of Health Research (NIHR)
Identifiers: 991014958002346; WOS:000790938100006
Academic Unit: School of Veterinary Medicine
Language: English
Resource Type: Journal article

Procalcitonin Is Not a Reliable Biomarker of Bacterial Coinfection in People With Coronavirus Disease 2019 Undergoing Microbiological Investigation at the Time of Hospital Admission

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