Pregnancy and neonatal outcomes of COVID-19: The PAN-COVID study

E. Mullins; A. Perry; J. Banerjee; J. Townson; D. Grozeva; R. Milton; N. Kirby; R. Playle; T. Bourne; C. Lees; Abby Rand; Aethele Khunda; Aleš Roztočil; Alexandra J Kermack; Ami Mackay; Amit Verma; Amna Ahmed; Amy Mahdi; Anam Fayadh; Andrea Dall'Asta; Andrea Harrington; Angeliki Gerede; Avideah Nejad; Barkha Sinha; Beth Peers; Bev Hammond; Bini Ajay; Caroline Dixon; Caroline Everden; Carrie Heal; Catherine Bressington; Cheryl Wyatt; Chris Flood; Christine Möller-Christensen; Clare O'Brien; Coralie Glenn-Sansum; Coralie Huson; Dimitrios Rallis; Donna Perkins; Donna Southam; Donna Wixted; Alexandra Viner; Anila Asghar; Antony Nicoll; Caroline Knight; Gillian McKeown; Hema Divakar; Plastiras Panagiotis Christofidis; Prakash Satodia; Rachel Liebling; Rita Arya; Rukhsana Kousar; Ruta Gada; Sankara Narayanan; Stamatina Iliodromiti; Vibha Giri; Vimal Vasu; Wassim Hassan; Zoe Woodward; E. Mutema; Eleanor MK Jarvie; Elena Romero; Emma Collins; Emma Meadows; Emma Mills; Emma Tanton; Enxhi Vrapi; Ernawati Darmawan; Fabio Barra; Federico Prefumo; Fidelma Lee; Hayley L. Martin; Helen Gbinigie; Helen Millward; Hilary Owen; Isobel Crawford; Jacqueline Tipper; Jacqui Jennings; Jamie-Louise Raven; Jane Cantliffe; Jane Radford; Janet Cresswell; Jennifer Syson; Jessie Brain; Joanna Mead; Jude Mossop; Julie Goddard; Julie Grindey; Karen Cloherty; Karen Watkins; Kate Robinson; Katie Barker; Kerry Elliott; Kim Hinshaw; Kirsty Revell; Laura Camarasa; Laura Harris; Laurie Windsor; Leanne Sherris; Lianne Chapman; Linda Bishop; Liona Chiu Yee POON; Lisa Frankland; Liz Glyn-Jones; Louise Emmet; Louise Swaminathan; M.I Aldika Akbar; Maggie Armstrong; Mahalakshmi Gorti; Mairead Black; Mani Malarselvi; Manjiri Khare; Mark Chester; Martina Andrasova; Maryanne Bray; Mauro Parra-Cordero; M D Roland Berger; Michelle Anderson; Millicent Anim-Somuah; Mingxing Xie; Miriam Bourke; Mohamed Elbahnasawy; Mohamed Sobhy Bakry; Ahmar Shah; B A Rather; David Churchill; Ling Wee; Salman Kidwai; Trevor Balling; Allison Amin; Sandra Essien; Ms Sameena Kausar; Ms.Jyothi Rajeswary; Muglu Javaid; Narendra Aladangady; Neil Shah; Nichola Bale; Nicky Mason; Pensée Wu; Lavinia Margarit; Rabia Zill-e-Huma; Rachel Newport; Robin Hughes; Roobin Jokhi; Roshni Mansfield; Ru Davies; Ruth Davies; Sam Ratcliffe; Sandra Greer; Sarah Coxon; Sarah Ekladios; Sarah Stables; Shanteela McCooty; Sharon Gowans; Sharon Jones; Shazia Jaleel; Shelly Higgins; Sherry Halawa; Siân C Harrington; Sophie Robinson; Soum Nallapeta; Stephanie Grigsby; Susara Blunden; SSA Tiziana Frusca; Veerareddy Sukrutha; Vicki Atkinson; Victoria Murtha; Waldo Germán Caro; Zoe Garner; The PAN-COVID Investigators

doi:10.1016/j.ejogrb.2022.07.010

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Pregnancy and neonatal outcomes of COVID-19: The PAN-COVID study

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Pregnancy and neonatal outcomes of COVID-19: The PAN-COVID study

E. Mullins, A. Perry, J. Banerjee, J. Townson, D. Grozeva, R. Milton, N. Kirby, R. Playle, T. Bourne, C. Lees, …

European journal of obstetrics & gynecology and reproductive biology, Vol.276, pp.161-167

01/09/2022

DOI: https://doi.org/10.1016/j.ejogrb.2022.07.010

PMID: 35914420

Abstract

COVID

Fetal

Fetal growth restriction

Infection

Neonatal

Perinatal

Pregnancy

SARS-CoV-2

Stillbirth

To assess perinatal outcomes for pregnancies affected by suspected or confirmed SARS-CoV-2 infection. Prospective, web-based registry. Pregnant women were invited to participate if they had suspected or confirmed SARS-CoV-2 infection between 1st January 2020 and 31st March 2021 to assess the impact of infection on maternal and perinatal outcomes including miscarriage, stillbirth, fetal growth restriction, pre-term birth and transmission to the infant. Between April 2020 and March 2021, the study recruited 8239 participants who had suspected or confirmed SARs-CoV-2 infection episodes in pregnancy between January 2020 and March 2021. Maternal death affected 14/8197 (0.2%) participants, 176/8187 (2.2%) of participants required ventilatory support. Pre-eclampsia affected 389/8189 (4.8%) participants, eclampsia was reported in 40/ 8024 (0.5%) of all participants. Stillbirth affected 35/8187 (0.4 %) participants. In participants delivering within 2 weeks of delivery 21/2686 (0.8 %) were affected by stillbirth compared with 8/4596 (0.2 %) delivering ≥ 2 weeks after infection (95 % CI 0.3–1.0). SGA affected 744/7696 (9.3 %) of livebirths, FGR affected 360/8175 (4.4 %) of all pregnancies. Pre-term birth occurred in 922/8066 (11.5%), the majority of these were indicated pre-term births, 220/7987 (2.8%) participants experienced spontaneous pre-term births. Early neonatal deaths affected 11/8050 livebirths. Of all neonates, 80/7993 (1.0%) tested positive for SARS-CoV-2. Infection was associated with indicated pre-term birth, most commonly for fetal compromise. The overall proportions of women affected by SGA and FGR were not higher than expected, however there was the proportion affected by stillbirth in participants delivering within 2 weeks of infection was significantly higher than those delivering ≥ 2 weeks after infection. We suggest that clinicians’ threshold for delivery should be low if there are concerns with fetal movements or fetal heart rate monitoring in the time around infection. The proportion affected by pre-eclampsia amongst participants was not higher than would be expected, although we report a higher than expected proportion affected by eclampsia. There appears to be no effect on birthweight or congenital malformations in women affected by SARS-CoV-2 infection in pregnancy and neonatal infection is uncommon. This study reflects a population with a range of infection severity for SARS-COV-2 in pregnancy, generalisable to whole obstetric populations.

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Title: Pregnancy and neonatal outcomes of COVID-19: The PAN-COVID study
Creators: E. Mullins - Imperial College London
A. Perry - Imperial College London
J. Banerjee - Imperial College Healthcare NHS Trust
J. Townson - Cardiff University
D. Grozeva - Cardiff University
R. Milton - Cardiff University
N. Kirby - Cardiff University
R. Playle - Cardiff University
T. Bourne - Imperial College London
C. Lees - Imperial College London
Abby Rand - Salisbury District Hospital
Aethele Khunda - Consultant Gynaecologist, South TEES Hospitals NHS Trust, UK
Aleš Roztočil - Jihlava Hospital, Czech Republic
Alexandra J Kermack - University Hospital Southampton NHS Foundation Trust
Ami Mackay - Somerset NHS Foundation Trust
Amit Verma - Royal Albert Edward Infirmary
Amna Ahmed - South Tyneside and Sunderland NHS Foundation Trust
Amy Mahdi - Liverpool Women's NHS Foundation Trust, UK
Anam Fayadh - Northwick Park Hospital
Andrea Dall'Asta - U.O. OSTETRICIA E GINECOLOGIA, AZIENDA OSPEDALIERO-UNIVERSITARIA DI PARMA, Italy
Andrea Harrington - Mid and South Essex Hospital Services NHS Trust, Southend University Hospital, UK
Angeliki Gerede - Maternal Fetal Medicine Subspecialist, 3rd Dept. Obstetrics & Gynecology Medical School Aristotle University of Thessaloniki, Secretary General of the Hellenic Society of Maternal Fetal Medicine, Greece
Avideah Nejad - Hull University Teaching Hospitals NHS Trust, UK
Barkha Sinha - West Suffolk NHS Foundation Trust
Beth Peers - Ashford and St Peter's Hospitals NHS Foundation Trust
Bev Hammond - Senior Research Midwife and Team Leader, East Lancashire Teaching Hospitals NHS Trust, UK
Bini Ajay - Croydon University Hospital
Caroline Dixon - Mid Cheshire Hospitals NHS Foundation Trust
Caroline Everden - Royal Surrey NHS Foundation Trust
Carrie Heal - Stockport NHS Foundation Trust
Catherine Bressington - Royal United Hospitals Bath NHS Foundation Trust, Royal United Hospital, UK
Cheryl Wyatt - Lancashire Teaching Hospitals NHS Foundation Trust
Chris Flood - United Lincolnshire Hospitals NHS Trust
Christine Möller-Christensen - Gateshead Health NHS Foundation Trust
Clare O'Brien - RM, Lead Research Midwife, South Warwickshire Foundation Trust, Warwick, CV34 5BW, UK
Coralie Glenn-Sansum - Peterborough City Hospital
Coralie Huson - North West Anglia NHS Foundation Trust, Peterborough City Hospital/Hitchinbrooke Hospital, UK
Dimitrios Rallis - University of Ioannina
Donna Perkins - Walsall Healthcare NHS Trust
Donna Southam - Mid and South Essex Hospital Services NHS Trust/Basildon and Thurrock University Hospitals NHS Foundation Trust, Basildon University Hospital, UK
Donna Wixted - Dorset County Hospital NHS Foundation Trust
Alexandra Viner - NHS Lothian
Anila Asghar - Black Country Healthcare NHS Foundation Trust
Antony Nicoll - NHS Tayside
Caroline Knight - Guy's and St Thomas' NHS Foundation Trust
Gillian McKeown - Craigavon Area Hospital
Hema Divakar - Divakars Speciality Hospital, India
Plastiras Panagiotis Christofidis - Dept. Obstet&Gyn “Arch. Makarios III” Hospital, Nicosia, Cyprus
Prakash Satodia - University of Warwick
Rachel Liebling - University Hospitals Bristol and Weston NHS Foundation Trust
Rita Arya - Warrington and Halton Teaching Hospitals NHS Foundation Trust
Rukhsana Kousar - Mid Yorkshire Hospitals NHS Trust
Ruta Gada - East Suffolk and North Essex NHS Foundation Trust
Sankara Narayanan - West Hertfordshire Hospitals NHS Trust
Stamatina Iliodromiti - Barts Health NHS Trust
Vibha Giri - Good Hope Hospital
Vimal Vasu - William Harvey Hospital
Wassim Hassan - East Suffolk and North Essex NHS Foundation Trust
Zoe Woodward - East Kent Hospitals University NHS Foundation Trust
E. Mutema - Imperial College Healthcare NHS Trust
Eleanor MK Jarvie - Consultant Obstetrician, University Hospital Wishaw, NHS Lanarkshire, ML2 0DP, UK
Elena Romero - Cambridge University Hospitals NHS Foundation Trust
Emma Collins - Wye Valley NHS Trust
Emma Meadows - Research midwife, St Richards Hospital, University Hospitals Sussex, UK
Emma Mills - Aneurin Bevan University Health Board
Emma Tanton - Bolton NHS Foundation Trust
Enxhi Vrapi - UHOG 'Koço Gliozheni', Obstetrics Department/High Risk Pregnancy Department, UK
Ernawati Darmawan - Academic Medical Center
Fabio Barra - Ospedale Policlinico San Martino
Federico Prefumo - University of Brescia
Fidelma Lee - Imperial College Healthcare NHS Trust
Hayley L. Martin - King's College Hospital NHS Foundation Trust
Helen Gbinigie - Medway NHS Foundation Trust
Helen Millward - Shrewsbury and Telford Hospital NHS Trust
Hilary Owen - Betsi Cadwaladr University Health Board
Isobel Crawford - Research Midwife, Glasgow Clinical Research Facility, UK
Jacqueline Tipper - Phillips Exeter Academy
Jacqui Jennings - Darlington Memorial Hospital
Jamie-Louise Raven - James Paget University Hospitals NHS Foundation Trust
Jane Cantliffe - Nottingham University Hospitals NHS Trust
Jane Radford - University Hospitals of Derby, Burton NHS Foundation Trust, Queen’s Hospital, Burton/Royal Derby Hospital, UK
Janet Cresswell - Chesterfield Royal Hospital
Jennifer Syson - Bradford Teaching Hospitals NHS Foundation Trust
Jessie Brain - Worcestershire Acute Hospitals NHS Trust
Joanna Mead - Milton Keynes University Hospital NHS Foundation Trust, Milton Keynes University Hospital, UK
Jude Mossop - Senior Research Midwife, Nuffield Department of Women's and Reproductive Health, University of Oxford, Oxford University Hospitals NHS Foundation Trust, Oxford, OX3 9DU, UK
Julie Goddard - Calderdale and Huddersfield NHS Foundation Trust
Julie Grindey - University Teaching Hospital
Karen Cloherty - Torbay Hospital
Karen Watkins - Royal Cornwall Hospital
Kate Robinson - Leeds Teaching Hospitals NHS Trust
Katie Barker - Northumbria Healthcare NHS Foundation Trust
Kerry Elliott - York Teaching Hospital NHS Foundation Trust
Kim Hinshaw - Sunderland Royal Hospital
Kirsty Revell - Basingstoke and North Hampshire Hospital
Laura Camarasa - Hillingdon Hospitals NHS Foundation Trust
Laura Harris - Norfolk and Norwich University Hospitals NHS Foundation Trust
Laurie Windsor - Devon Partnership NHS Trust
Leanne Sherris - Hull University Teaching Hospitals NHS Trust, UK
Lianne Chapman - Frimley Health NHS Foundation Trust
Linda Bishop - Southport and Ormskirk Hospital NHS Trust
Liona Chiu Yee POON - Prince of Wales Hospital, UK
Lisa Frankland - Buckinghamshire Healthcare NHS Trust
Liz Glyn-Jones - Research Midwife, Powys Teaching Health Board, Sites: Ystradgynlais, Brecon, Llandrindod Wells, Knighton, Llanidloes, Machynlleth, Newtown, Welshpool, UK
Louise Emmet - Epsom and St Helier University Hospitals NHS Trust
Louise Swaminathan - Maidstone and Tunbridge Wells NHS Trust
M.I Aldika Akbar - Universitas Airlangga Hospital, Universitas Airlangga Hospital, Indonesia
Maggie Armstrong - Betsi Cadwaladr University Health Board
Mahalakshmi Gorti - Surrey and Sussex Healthcare NHS Trust
Mairead Black - University of Aberdeen
Mani Malarselvi - University Hospitals Birmingham NHS Foundation Trust
Manjiri Khare - University Hospitals of Leicester NHS Trust
Mark Chester - Royal Derby Hospital
Martina Andrasova - General University Hospital Prague, Prenatal Diagnostic Centre, Czech Republic
Maryanne Bray - Cardiff and Vale University Health Board
Mauro Parra-Cordero - University of Chile
M D Roland Berger - St. Josef Krankenhaus
Michelle Anderson - Royal Free London NHS Foundation Trust
Millicent Anim-Somuah - Tameside and Glossop Integrated Care NHS Foundation Trust
Mingxing Xie - Tongji Medical College of HUST, Union Hospital, Wuhan, China
Miriam Bourke - Chelsea and Westminster Hospital NHS Foundation Trust, Chelsea and Westminster Hospital/West Middlesex University Hospital, UK
Mohamed Elbahnasawy - Tanta University
Mohamed Sobhy Bakry - Fayoum University
Ahmar Shah - Yeovil District Hospital NHS Foundation Trust
B A Rather - Imperial College Healthcare NHS Trust
David Churchill - The Royal Wolverhampton NHS Trust
Ling Wee - Princess Alexandra Hospital NHS Trust
Salman Kidwai - Queen Elizabeth Hospital King's Lynn NHS Foundation Trust
Trevor Balling - Countess of Chester Hospital NHS Foundation Trust
Allison Amin - Harrogate and District NHS Foundation Trust
Sandra Essien - North Middlesex University Hospital NHS Trust
Ms Sameena Kausar - Broomfield Hospital
Ms.Jyothi Rajeswary - Consultant obstetrician and Gynaecologist, Lead Research Obstetrician, Sherwood Forest Hospital NHS Trust, Mansfield NG17 4JL, UK
Muglu Javaid - Lewisham and Greenwich NHS Trust, University Hospital Lewisham/Queen Elizabeth Hospital Woolwich, UK
Narendra Aladangady - Homerton University Hospital NHS Foundation Trust
Neil Shah - Sandwell and West Birmingham Hospitals NHS Trust, City Hospital Birmingham/Sandwell General Hospital, UK
Nichola Bale - North Bristol NHS Trust
Nicky Mason - East Sussex Healthcare NHS Trust
Pensée Wu - University Hospitals of North Midlands NHS Trust
Lavinia Margarit - Swansea University
Rabia Zill-e-Huma - East and North Hertfordshire NHS Trust
Rachel Newport - Pennine Acute Hospitals NHS Trust
Robin Hughes - York Teaching Hospital NHS Foundation Trust
Roobin Jokhi - Sheffield Teaching Hospitals NHS Foundation Trust
Roshni Mansfield - Imperial College Healthcare NHS Trust
Ru Davies - Great Western Hospitals NHS Foundation Trust
Ruth Davies - Great Western Hospitals NHS Foundation Trust
Sam Ratcliffe - Manchester University NHS Foundation Trust
Sandra Greer - St Helens and Knowsley Hospital Services NHS Trust, Whiston Hospital/St Helens Hospital, UK
Sarah Coxon - Frimley Health NHS Foundation Trust
Sarah Ekladios - University College London Hospitals NHS Foundation Trust
Sarah Stables - Barnsley Hospital NHS Foundation Trust
Shanteela McCooty - Lead Research Nurse, Research and Development Department, Birmingham Women's and Children's NHS FT Hospital, UK
Sharon Gowans - North Tees and Hartlepool NHS Foundation Trust
Sharon Jones - Swansea Bay University Health Board
Shazia Jaleel - George Eliot Hospital NHS Trust
Shelly Higgins - Powys Teaching Health Board – Ystradgynlais, Ystradgynlais, Brecon, Llandrindod Wells, Knighton, Llanidloes, Machynlleth, Newtown, Welshpool, UK
Sherry Halawa - University Hospitals Plymouth NHS Trust
Siân C Harrington - Gloucestershire Hospitals NHS Foundation Trust
Sophie Robinson - St. George's University
Soum Nallapeta - Airedale NHS Foundation Trust
Stephanie Grigsby - University Hospitals Dorset NHS Foundation Trust
Susara Blunden - Poole Hospital NHS Foundation Trust
SSA Tiziana Frusca - U.O. Ostetricia e Ginecologia, Azienda Ospedaliero-Universitaria Di Parma, Italy
Veerareddy Sukrutha - Pennine Acute Hospitals NHS Trust
Vicki Atkinson - University Hospital of North Durham
Victoria Murtha - Newcastle upon Tyne Hospitals NHS Foundation Trust
Waldo Germán Caro - Hospital Florencio Díaz, Clinica Universitaria Reina Fabiola, Córdoba, Argentina
Zoe Garner - Portsmouth Hospitals NHS Trust
The PAN-COVID Investigators
Publication Details: European journal of obstetrics & gynecology and reproductive biology, Vol.276, pp.161-167
Publisher: Elsevier B.V
Number of pages: 7
Publication Date: 01/09/2022
Identifiers: 99994472802346; WOS:000922631500017
Academic Unit: School of Medicine
Language: English
Resource Type: Journal article

Pregnancy and neonatal outcomes of COVID-19: The PAN-COVID study

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