Abstract
The most accurate results were observed in the study varying physical-activity level, where our model predicted weight-loss to 100% accuracy in both the caloric-restriction and the caloric-restriction-plus exercise groups. A high degree of accuracy was also observed in the study varying degree of caloric restriction, with predicted weight-loss deviating only by 1 and 2 kg from observed weight-loss in the low-calorie-diet and very-low-calorie-diet groups, respectively. 1 Low-fat high-carbohydrate 2 High-fat low-carbohydrate 3 Caloric restriction 4 Energy expended by exercise 5 Low-calorie diet 6 Very low-calorie diet Our model provides further evidence challenging the 3500 kcal rule by illustrating the physiological influence of adaptive thermogenesis, diet-induced thermogenesis and body-composition on weight-loss.