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Novel acylated steroidal glycosides from Caralluma tuberculata induce caspase-dependent apoptosis in cancer cells.
Journal article   Peer reviewed

Novel acylated steroidal glycosides from Caralluma tuberculata induce caspase-dependent apoptosis in cancer cells.

A Waheed, J Barker, SJ Barton, GM Khan, Q Najm-Us-Saqib, M Hussain, S Ahmed, C Owen and MA Carew
J Ethnopharmacol, Vol.137(3), pp.1189-1196
11/10/2011
DOI: https://doi.org/10.1016/j.jep.2011.07.049

Abstract

Acylation Amino Acid Chloromethyl Ketones Androstanols Antineoplastic Agents Phytogenic Apoptosis Asclepiadaceae Blotting Western Caco-2 Cells Caspase Inhibitors Caspases Cell Proliferation Cell Survival Chemical Fractionation Chromatography Cysteine Proteinase Inhibitors Dose-Response Relationship Drug Glycosides Human Umbilical Vein Endothelial Cells Humans Magnetic Resonance Spectroscopy Mass Spectrometry Molecular Structure Neoplasms Plants Medicinal Poly(ADP-ribose) Polymerases Pregnanes Structure-Activity Relationship U937 Cells
Pregnane glycosides are potent cytotoxic agents which may represent new leads in the development of anti-tumour drugs, particularly in the treatment of breast cancer, because of the structural similarity to estrogenic agonists. Caralluma species are natural sources of a wide variety of pregnane glycosides. The aim of the study was to isolate, using an activity-guided fractionation approach, novel pregnane glycosides for testing on breast cancer and other tumour lines.

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