Nifurtimox Activation by Trypanosomal Type I Nitroreductases Generates Cytotoxic Nitrile Metabolites

BS Hall; C Bot; SR Wilkinson

doi:10.1074/jbc.M111.230847

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Nifurtimox Activation by Trypanosomal Type I Nitroreductases Generates Cytotoxic Nitrile Metabolites

Journal article

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Nifurtimox Activation by Trypanosomal Type I Nitroreductases Generates Cytotoxic Nitrile Metabolites

BS Hall, C Bot and SR Wilkinson

JOURNAL OF BIOLOGICAL CHEMISTRY, Vol.286(15), pp.13088-13095

15/04/2011

DOI: https://doi.org/10.1074/jbc.M111.230847

Abstract

Science & Technology

Life Sciences & Biomedicine

Biochemistry & Molecular Biology

BIOCHEMISTRY & MOLECULAR BIOLOGY

ESCHERICHIA-COLI

TRYPANOTHIONE REDUCTASE

NITROHETEROCYCLIC DRUGS

NITROAROMATIC COMPOUNDS

CATALYTIC PROPERTIES

CHAGAS-DISEASE

FREE-RADICALS

CRUZI

RESISTANCE

BENZNIDAZOLE

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Title: Nifurtimox Activation by Trypanosomal Type I Nitroreductases Generates Cytotoxic Nitrile Metabolites
Creators: BS Hall
C Bot
SR Wilkinson
Publication Details: JOURNAL OF BIOLOGICAL CHEMISTRY, Vol.286(15), pp.13088-13095
Publisher: AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
Date published: 15/04/2011
Date submitted: 17/05/2017
Identifiers: 99514882102346
Academic Unit: University of Surrey
Language: English
Resource Type: Journal article

Nifurtimox Activation by Trypanosomal Type I Nitroreductases Generates Cytotoxic Nitrile Metabolites

Abstract

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