New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk

Yingchang Lu; Felix R Day; Stefan Gustafsson; Martin L Buchkovich; Jianbo Na; Veronique Bataille; Diana L Cousminer; Zari Dastani; Alexander W Drong; Tõnu Esko; David M Evans; Mario Falchi; Mary F Feitosa; Teresa Ferreira; Åsa K Hedman; Robin Haring; Pirro G Hysi; Mark M Iles; Anne E Justice; Stavroula Kanoni; Vasiliki Lagou; Rui Li; Xin Li; Adam Locke; Chen Lu; Reedik Mägi; John R B Perry; Tune H Pers; Qibin Qi; Marianna Sanna; Ellen M Schmidt; William R Scott; Dmitry Shungin; Alexander Teumer; Anna A E Vinkhuyzen; Ryan W Walker; Harm-Jan Westra; Mingfeng Zhang; Weihua Zhang; Jing Hua Zhao; Zhihong Zhu; Uzma Afzal; Tarunveer Singh Ahluwalia; Stephan J L Bakker; Claire Bellis; Amélie Bonnefond; Katja Borodulin; Aron S Buchman; Tommy Cederholm; Audrey C Choh; Hyung Jin Choi; Joanne E Curran; Lisette C P G M de Groot; Philip L De Jager; Rosalie A M Dhonukshe-Rutten; Anke W Enneman; Elodie Eury; Daniel S Evans; Tom Forsen; Nele Friedrich; Frédéric Fumeron; Melissa E Garcia; Simone Gärtner; Bok-Ghee Han; Aki S Havulinna; Caroline Hayward; Dena Hernandez; Hans Hillege; Till Ittermann; Jack W Kent; Ivana Kolcic; Tiina Laatikainen; Jari Lahti; Irene Mateo Leach; Christine G Lee; Jong-Young Lee; Tian Liu; Youfang Liu; Stéphane Lobbens; Marie Loh; Leo-Pekka Lyytikäinen; Carolina Medina-Gomez; Karl Michaëlsson; Mike A Nalls; Carrie M Nielson; Laticia Oozageer; Laura Pascoe; Lavinia Paternoster; Ozren Polašek; Samuli Ripatti; Mark A Sarzynski; Chan Soo Shin; Nina Smolej Narančić; Dominik Spira; Priya Srikanth; Elisabeth Steinhagen-Thiessen; Yun Ju Sung; Karin M A Swart; Leena Taittonen; Toshiko Tanaka; Ayse Demirkan

doi:10.1038/ncomms10495

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New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk

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New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk

Yingchang Lu, Felix R Day, Stefan Gustafsson, Martin L Buchkovich, Jianbo Na, Veronique Bataille, Diana L Cousminer, Zari Dastani, Alexander W Drong, Tõnu Esko, …

Nature communications, Vol.7(1), pp.10495-10495

01/02/2016

DOI: https://doi.org/10.1038/ncomms10495

PMID: 26833246

Abstract

Adiposity - genetics

Animals

Drosophila melanogaster - genetics

Drosophila melanogaster - metabolism

Gene Expression Regulation - physiology

Gene Knockdown Techniques

Genetic Predisposition to Disease

Genome-Wide Association Study

Heart Diseases - genetics

Humans

Quantitative Trait Loci - genetics

To increase our understanding of the genetic basis of adiposity and its links to cardiometabolic disease risk, we conducted a genome-wide association meta-analysis of body fat percentage (BF%) in up to 100,716 individuals. Twelve loci reached genome-wide significance (P<5 × 10(-8)), of which eight were previously associated with increased overall adiposity (BMI, BF%) and four (in or near COBLL1/GRB14, IGF2BP1, PLA2G6, CRTC1) were novel associations with BF%. Seven loci showed a larger effect on BF% than on BMI, suggestive of a primary association with adiposity, while five loci showed larger effects on BMI than on BF%, suggesting association with both fat and lean mass. In particular, the loci more strongly associated with BF% showed distinct cross-phenotype association signatures with a range of cardiometabolic traits revealing new insights in the link between adiposity and disease risk.

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Title: New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk
Creators: Yingchang Lu - Icahn School of Medicine at Mount Sinai
Felix R Day - MRC Epidemiology Unit
Stefan Gustafsson - Uppsala University
Martin L Buchkovich - University of North Carolina at Chapel Hill
Jianbo Na - Icahn School of Medicine at Mount Sinai
Veronique Bataille - West Herts College
Diana L Cousminer - Institute for Molecular Medicine Finland
Zari Dastani - Jewish General Hospital
Alexander W Drong - Wellcome Centre for Human Genetics
Tõnu Esko - Harvard Medical School
David M Evans - Translational Research Institute
Mario Falchi - King's College London
Mary F Feitosa - Washington University in St. Louis
Teresa Ferreira - Wellcome Centre for Human Genetics
Åsa K Hedman - Uppsala University
Robin Haring - Universitätsmedizin Greifswald
Pirro G Hysi - King's College London
Mark M Iles - University of Leeds
Anne E Justice - University of North Carolina at Chapel Hill
Stavroula Kanoni - William Harvey Research Institute
Vasiliki Lagou - Wellcome Centre for Human Genetics
Rui Li - Jewish General Hospital
Xin Li - Harvard University
Adam Locke - University of Michigan–Ann Arbor
Chen Lu - Boston University
Reedik Mägi - Wellcome Centre for Human Genetics
John R B Perry - University of Cambridge
Tune H Pers - Boston Children's Hospital
Qibin Qi - Albert Einstein College of Medicine
Marianna Sanna - King's College London
Ellen M Schmidt - University of Michigan–Ann Arbor
William R Scott - Imperial College London
Dmitry Shungin - Skåne University Hospital
Alexander Teumer - Universitätsmedizin Greifswald
Anna A E Vinkhuyzen - University of Queensland
Ryan W Walker - Icahn School of Medicine at Mount Sinai
Harm-Jan Westra - Broad Institute
Mingfeng Zhang - Brigham and Women's Hospital
Weihua Zhang - Imperial College London
Jing Hua Zhao - University of Cambridge
Zhihong Zhu - University of Queensland
Uzma Afzal - Imperial College London
Tarunveer Singh Ahluwalia - University of Copenhagen
Stephan J L Bakker - University Medical Center Groningen
Claire Bellis - Texas Biomedical Research Institute
Amélie Bonnefond - Université de Lille
Katja Borodulin - Finnish Institute for Health and Welfare
Aron S Buchman - Rush University Medical Center
Tommy Cederholm - Uppsala University
Audrey C Choh - Wright State University
Hyung Jin Choi - Seoul National University
Joanne E Curran - The University of Texas Rio Grande Valley
Lisette C P G M de Groot - Wageningen University
Philip L De Jager - Broad Institute
Rosalie A M Dhonukshe-Rutten - Wageningen University & Research
Anke W Enneman - Erasmus MC
Elodie Eury - Centre National de la Recherche Scientifique
Daniel S Evans - California Pacific Medical Center
Tom Forsen - University of Helsinki
Nele Friedrich - Universitätsmedizin Greifswald
Frédéric Fumeron - Inserm
Melissa E Garcia - National Institute on Aging
Simone Gärtner - Universitätsmedizin Greifswald
Bok-Ghee Han - Center for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, Chungcheongbuk-do 370914, Korea
Aki S Havulinna - Finnish Institute for Health and Welfare
Caroline Hayward - MRC Institute of Genetics and Molecular Medicine
Dena Hernandez - National Institute on Aging
Hans Hillege - University Medical Center Groningen
Till Ittermann - Universitätsmedizin Greifswald
Jack W Kent - Texas Biomedical Research Institute
Ivana Kolcic - University of Split
Tiina Laatikainen - Finnish Institute for Health and Welfare
Jari Lahti - Folkhälsans Forskningscentrum
Irene Mateo Leach - University Medical Center Groningen
Christine G Lee - Oregon Health & Science University
Jong-Young Lee - Center for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, Chungcheongbuk-do 370914, Korea
Tian Liu - Max Planck Institute for Human Development
Youfang Liu - University of North Carolina at Chapel Hill
Stéphane Lobbens - Université de Lille
Marie Loh - Imperial College London
Leo-Pekka Lyytikäinen - University of Tampere
Carolina Medina-Gomez - Erasmus MC
Karl Michaëlsson - Uppsala University
Mike A Nalls - National Institute on Aging
Carrie M Nielson - Oregon Health & Science University
Laticia Oozageer - Ealing Hospital
Laura Pascoe - Newcastle University
Lavinia Paternoster - University of Bristol
Ozren Polašek - University of Split
Samuli Ripatti - Wellcome Sanger Institute
Mark A Sarzynski - Pennington Biomedical Research Center
Chan Soo Shin - Seoul National University
Nina Smolej Narančić - Institute for Anthropological Research
Dominik Spira - Charité - Universitätsmedizin Berlin
Priya Srikanth - Oregon Health & Science University
Elisabeth Steinhagen-Thiessen - Charité - Universitätsmedizin Berlin
Yun Ju Sung - Division of Biostatistics, Washington University School of Medicine, St Louis, Missouri 63110, USA
Karin M A Swart - EMGO Institute for Health and Care Research
Leena Taittonen - University of Oulu
Toshiko Tanaka - National Institute on Aging
Ayse Demirkan - Institute for Sustainability
Publication Details: Nature communications, Vol.7(1), pp.10495-10495
Date published: 01/02/2016
Grant note: Wellcome Trust Department of Health MC_UU_12015/5 / Medical Research Council British Heart Foundation MC_UU_12011/4 / Medical Research Council R01 DK072193 / NIDDK NIH HHS R01 AG027574 / NIA NIH HHS MR/J012165/1 / Medical Research Council MC_U147574242 / Medical Research Council MC_UP_A620_1016 / Medical Research Council
Identifiers: 99928691102346
Academic Unit: Institute for Sustainability; Surrey Institute for People-Centred AI; School of Biosciences
Language: English
Resource Type: Journal article

New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk

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